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OtherTheranostics

Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 (177Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer

John Violet, Shahneen Sandhu, Amir Iravani, Justin Ferdinandus, Sue Ping Thang, Grace Kong, Aravind Ravi Kumar, Tim Akhurst, David A. Pattison, Alexis Beaulieu, Jennifer Mooi, Christina Guo, Victor Kalff, Declan G Murphy, Price Jackson, Peter Eu, Mark Scalzo, Scott Williams, Rod J Hicks and Michael S Hofman
Journal of Nuclear Medicine November 2019, jnumed.119.236414; DOI: https://doi.org/10.2967/jnumed.119.236414
John Violet
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Shahneen Sandhu
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Amir Iravani
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Justin Ferdinandus
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Sue Ping Thang
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Grace Kong
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Aravind Ravi Kumar
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Tim Akhurst
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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David A. Pattison
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Alexis Beaulieu
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Jennifer Mooi
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Christina Guo
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Victor Kalff
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Declan G Murphy
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Price Jackson
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Peter Eu
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Mark Scalzo
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Scott Williams
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Rod J Hicks
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Michael S Hofman
Peter MacCallum Cancer Centre, Melbourne VIC, Australia, AUSTRALIA
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 (177Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer
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Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 (177Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer
John Violet, Shahneen Sandhu, Amir Iravani, Justin Ferdinandus, Sue Ping Thang, Grace Kong, Aravind Ravi Kumar, Tim Akhurst, David A. Pattison, Alexis Beaulieu, Jennifer Mooi, Christina Guo, Victor Kalff, Declan G Murphy, Price Jackson, Peter Eu, Mark Scalzo, Scott Williams, Rod J Hicks, Michael S Hofman
Journal of Nuclear Medicine Nov 2019, jnumed.119.236414; DOI: 10.2967/jnumed.119.236414

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Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 (177Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer
John Violet, Shahneen Sandhu, Amir Iravani, Justin Ferdinandus, Sue Ping Thang, Grace Kong, Aravind Ravi Kumar, Tim Akhurst, David A. Pattison, Alexis Beaulieu, Jennifer Mooi, Christina Guo, Victor Kalff, Declan G Murphy, Price Jackson, Peter Eu, Mark Scalzo, Scott Williams, Rod J Hicks, Michael S Hofman
Journal of Nuclear Medicine Nov 2019, jnumed.119.236414; DOI: 10.2967/jnumed.119.236414
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Cited By...

  • Clinical Trial Protocol for LuCAB: A Phase I-II Trial Evaluating Cabazitaxel in Combination with [177Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer
  • Safety and Efficacy of 20 Cycles of [177Lu]Lu-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
  • The Role of PSMA PET Parameters as Biomarkers for Response to PSMA-Targeted Radiopharmaceutical Therapy
  • Challenges with 177Lu-PSMA-617 Radiopharmaceutical Therapy in Clinical Practice
  • Impact of Posttreatment SPECT/CT on Patient Management During 177Lu-PSMA-617 Radiopharmaceutical Therapy
  • Prostate-Specific Membrane Antigen-Targeted Imaging and Its Correlation with HOXB13 Expression
  • Clinical Trial Protocol for VIOLET: A Single-Center, Phase I/II Trial Evaluation of Radioligand Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer with [161Tb]Tb-PSMA-I&T
  • Is 161Tb Really Happening?
  • Single-Time-Point Renal Dosimetry Using Nonlinear Mixed-Effects Modeling and Population-Based Model Selection in [177Lu]Lu-PSMA-617 Therapy
  • Differences and Common Ground in 177Lu-PSMA Radioligand Therapy Practice Patterns: International Survey of 95 Theranostic Centers
  • Unraveling the Impact of 177Lu-PSMA Radioligand Therapy on Renal Impairment: Distinguishing Causation from Correlation
  • Long-Term Nephrotoxicity of 177Lu-PSMA Radioligand Therapy
  • Improved Quality of Life in Metastatic Castration-Resistant Prostate Cancer Patients Receiving Consecutive Cycles of 177Lu-PSMA I&T
  • Albumin-Binding and Conventional PSMA Ligands in Combination with 161Tb: Biodistribution, Dosimetry, and Preclinical Therapy
  • SNMMI Consensus Statement on Patient Selection and Appropriate Use of 177Lu-PSMA-617 Radionuclide Therapy
  • SNMMI Consensus Statement on Patient Selection and Appropriate Use of 177Lu-PSMA-617 Radionuclide Therapy
  • Clinical Translation of Targeted {alpha}-Therapy: An Evolution or a Revolution?
  • Clinical Translation of Targeted {alpha}-Therapy: An Evolution or a Revolution?
  • 177Lu-PSMA SPECT Quantitation at 6 Weeks (Dose 2) Predicts Short Progression-Free Survival for Patients Undergoing 177Lu-PSMA-I&T Therapy
  • Evaluation of 177Lu-PSMA-617 SPECT/CT Quantitation as a Response Biomarker Within a Prospective 177Lu-PSMA-617 and NOX66 Combination Trial (LuPIN)
  • 177Lu-PSMA Therapy
  • Prostate-Specific Membrane Antigen Radioligand Therapy Using 177Lu-PSMA I&T and 177Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer: Comparison of Safety, Biodistribution, and Dosimetry
  • Effects of 225Ac-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer: A Meta-Analysis
  • A Comparison of 18F-DCFPyL, 18F-NaF, and 18F-FDG PET/CT in a Prospective Cohort of Men with Metastatic Prostate Cancer
  • The History of Prostate-Specific Membrane Antigen as a Theranostic Target in Prostate Cancer: The Cornerstone Role of the Prostate Cancer Foundation
  • Tumor Sink Effect in 68Ga-PSMA-11 PET: Myth or Reality?
  • Assessing Response to 177Lu-PSMA Radioligand Therapy Using Modified PSMA PET Progression Criteria
  • Dosimetry in Clinical Radiopharmaceutical Therapy of Cancer: Practicality Versus Perfection in Current Practice
  • Bringing VISION to Nuclear Medicine: Accelerating Evidence and Changing Paradigms with Theranostics
  • Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns
  • Radionuclide Therapy in Prostate Cancer: From Standalone to Combination PSMA Theranostics
  • RESIST-PC: U.S. Academic Foray into PSMA Theranostic Trials
  • Safety of PSMA-Targeted Molecular Radioligand Therapy with 177Lu-PSMA-617: Results from the Prospective Multicenter Phase 2 Trial RESIST-PC (NCT03042312)
  • Prospective phase 2 trial of PSMA-targeted molecular RadiothErapy with 177Lu-PSMA-617 for metastatic castration-reSISTant Prostate Cancer (RESIST-PC): efficacy results of the UCLA cohort
  • 177Lu-PSMA617 and the VISION Trial: One of the Greatest Success Stories in the History of Nuclear Medicine
  • Perspectives on Cutting-Edge Clinical Trials: A Conversation Between Michael Hofman, Johannes Czernin, and Jeremie Calais
  • The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer
  • John Violet: radiation oncologist and physician scientist who pioneered targeted radionuclide therapy for prostate cancer
  • Early Prostate-Specific Antigen Changes and Clinical Outcome After 177Lu-PSMA Radionuclide Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer
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Theranostics

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  • Evidence-Based Clinical Protocols to Monitor Efficacy of [177Lu]Lu-PSMA Radiopharmaceutical Therapy in Metastatic Castration-Resistant Prostate Cancer Using Real-World Data
  • 177Lu-Labeled Anticlaudin 6 Monoclonal Antibody for Targeted Therapy in Esophageal Cancer
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Clinical (Oncology: GU)

  • Pretherapeutic Comparative Dosimetry of 177Lu-rhPSMA-7.3 and 177Lu-PSMA I&T in Patients with Metastatic Castration-Resistant Prostate Cancer
  • A Comparison of 18F-DCFPyL, 18F-NaF, and 18F-FDG PET/CT in a Prospective Cohort of Men with Metastatic Prostate Cancer
  • Detection of Additional Primary Neoplasms on 18F-Fluciclovine PET/CT in Patients with Primary Prostate Cancer
Show more Clinical (Oncology: GU)

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Keywords

  • Genitourinary
  • Oncology: GU
  • radionuclide therapy
  • Lutetium-177
  • PSMA
  • prostate cancer
  • prostate specific membrane antigen
  • theranostics
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