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Journal of Nuclear Medicine

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Table of Contents

May 1, 2025; Volume 66,Issue 5

The State of the Art

  • You have access
    Treatment Landscape of Prostate Cancer in the Era of PSMA Radiopharmaceutical Therapy
    Fabio Turco, Silke Gillessen, Ken Herrmann, Gaetano Paone and Aurelius Omlin
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 665-672; DOI: https://doi.org/10.2967/jnumed.124.267730

Hot Topics

  • You have access
    RECIP 1.0: A Roadmap for Clinical Implementation
    Andrei Gafita, Loic Djaileb, Jeremie Calais, Matthias Eiber and Wolfgang P. Fendler
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 673-675; DOI: https://doi.org/10.2967/jnumed.124.268730

Focus on Molecular Imaging

  • Imaging the Activity of Efflux Transporters at the Blood–Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria
    You have access
    Imaging the Activity of Efflux Transporters at the Blood–Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria
    Nicolas Tournier and Oliver Langer
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 676-680; DOI: https://doi.org/10.2967/jnumed.124.269322

Is It Really Happening?

  • You have access
    Is 211At Really Happening?
    Richard Zimmermann
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 681-683; DOI: https://doi.org/10.2967/jnumed.125.269699

Editorial

  • You have access
    A Brief Report on the Results of the 2024 National Survey of Nuclear Medicine Conducted by the Chinese Society of Nuclear Medicine
    Jing Wang, Xiaoli Lan, Hongcheng Shi and Sijin Li
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 684-685; DOI: https://doi.org/10.2967/jnumed.124.269044

Oncology

  • Clinical

    • Tumor Asphericity in FDG PET Is an Independent Prognostic Parameter Improving Risk Stratification in Patients with Head and Neck Squamous Cell Carcinoma
      You have access
      Tumor Asphericity in FDG PET Is an Independent Prognostic Parameter Improving Risk Stratification in Patients with Head and Neck Squamous Cell Carcinoma
      Patrick Hausmann, Sebastian Zschaeck, Christian Furth, Pavel Nikulin, Paulina Cegla, Siyer Roohani, Elia Lombardo, Joanna Kazmierska, Nathalie L. Albert, Adrien Holzgreve, Iosif Strouthos, Claus Belka, Guillaume Landry, Witold Cholewinski, Jorg Kotzerke, Michael Baumann, Mechthild Krause, Daniel Zips, Jörg van den Hoff and Frank Hofheinz
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 686-691; DOI: https://doi.org/10.2967/jnumed.124.268972
    • <sup>18</sup>F-Fluoroestradiol PET/CT for Predicting Benefit from Endocrine Therapy in Patients with Estrogen Receptor–Positive Breast Cancer: A Systematic Review and Metaanalysis
      You have access
      18F-Fluoroestradiol PET/CT for Predicting Benefit from Endocrine Therapy in Patients with Estrogen Receptor–Positive Breast Cancer: A Systematic Review and Metaanalysis
      Ashwin Singh Parihar, Sofia Vaz, Siobhan Sutcliffe, Niharika Pant, Jan W. Schoones and Gary A. Ulaner
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 692-699; DOI: https://doi.org/10.2967/jnumed.124.269163
    • Diagnostic Potential of <sup>68</sup>Ga-NeoB PET/CT with Estrogen Receptor– and Progesterone Receptor–Positive Breast Cancer Undergoing Staging or Restaging for Metastatic Disease
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      Diagnostic Potential of 68Ga-NeoB PET/CT with Estrogen Receptor– and Progesterone Receptor–Positive Breast Cancer Undergoing Staging or Restaging for Metastatic Disease
      Zahra Sabahi, Andrew Nguyen, Keith Wong, Sherrington Li, Nathan Papa, Elgene Lim, Rachel F. Dear, Alexander M. Menzies, Frances Boyle, Yoland Antill, Belinda E. Kiely, Benjamin C. Forster, Cindy Mak, Diana Adams, Lina Pugliano, Andrew Spillane, Shikha Sharma, Adam Hickey, Aron Poole, Shikha Agrawal, Sobia Khan, Narjess Ayati and Louise Emmett
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 700-706; DOI: https://doi.org/10.2967/jnumed.124.268896

Theranostics

  • Clinical

    • FEATURED CLINICAL INVESTIGATION ARTICLE

      • <sup>177</sup>Lu-DOTATATE in Combination with PARP Inhibitor Olaparib Is Feasible in Patients with Somatostatin-Positive Tumors: Results from the LuPARP Phase I Trial
        You have access
        177Lu-DOTATATE in Combination with PARP Inhibitor Olaparib Is Feasible in Patients with Somatostatin-Positive Tumors: Results from the LuPARP Phase I Trial
        Andreas Hallqvist, Elva Brynjarsdóttir, Tomas Krantz, Marie Sjögren, Johanna Svensson and Peter Bernhardt
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 707-712; DOI: https://doi.org/10.2967/jnumed.124.268902
    • Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT in the proPSMA Study
      You have access
      Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [68Ga]Ga-PSMA-11 PET/CT in the proPSMA Study
      David C. Chen, James P. Buteau, Louise Emmett, Ramin Alipour, Felipe de Galiza Barbosa, Matthew J. Roberts, Aoife McVey, Jonathan O’Brien, Sidney Levy, Roslyn J. Francis, Nathan Lawrentschuk, Declan G. Murphy and Michael S. Hofman
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 713-718; DOI: https://doi.org/10.2967/jnumed.124.268901
    • Additive Value of [<sup>68</sup>Ga]Ga-RM26 PET/CT to [<sup>68</sup>Ga]Ga-PSMA-617 PET/CT in Detecting Pelvic Lymph Node Metastasis in Prostate Cancer: A Prospective, Single-Center, Phase II Study
      You have access
      Additive Value of [68Ga]Ga-RM26 PET/CT to [68Ga]Ga-PSMA-617 PET/CT in Detecting Pelvic Lymph Node Metastasis in Prostate Cancer: A Prospective, Single-Center, Phase II Study
      Wei Tang, Lin Qi, Minfeng Chen, Ye Zhang, Yongxiang Tang, Shuo Hu, Xiaomei Gao and Yi Cai
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 719-725; DOI: https://doi.org/10.2967/jnumed.124.269189
    • PET- and CT-Based Imaging Criteria for Response Assessment of Gastroenteropancreatic Neuroendocrine Tumors Under Radiopharmaceutical Therapy
      You have access
      PET- and CT-Based Imaging Criteria for Response Assessment of Gastroenteropancreatic Neuroendocrine Tumors Under Radiopharmaceutical Therapy
      Felix L. Herr, Christian Dascalescu, Matthias P. Fabritius, Gabriel T. Sheikh, Mathias J. Zacherl, Vera Wenter, Lena M. Unterrainer, Matthias Brendel, Adrien Holzgreve, Christoph J. Auernhammer, Christine Spitzweg, Tanja Burkard, Jens Ricke, Maurice M. Heimer and Clemens C. Cyran
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 726-731; DOI: https://doi.org/10.2967/jnumed.124.268621
    • First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen–Targeted <sup>212</sup>Pb Radioligand, in Patients with Metastatic Castration-Resistant Prostate Cancer
      Open Access
      First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen–Targeted 212Pb Radioligand, in Patients with Metastatic Castration-Resistant Prostate Cancer
      Kjetil Berner, Eivor Hernes, Monika Kvassheim, Mona-Elisabeth Revheim, Julie Bastiansen, Silje Selboe, Charlotte L. Bakken, Simen R. Grønningsæter, Øyvind S. Bruland, Roy H. Larsen, Lily Bouzelmat, Vicki L. Jardine and Caroline Stokke
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 732-738; DOI: https://doi.org/10.2967/jnumed.124.269299
    • Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives <sup>68</sup>Ga/<sup>177</sup>Lu-LNC1011 as Prostate Cancer Theranostics
      You have access
      Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives 68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics
      Hongzhang Yang, Jiarou Wang, Xuejun Wen, Huifeng Guo, Vivianne Jakobsson, Tianzhi Zhao, Fantian Zeng, Huaxiang Shen, Heng Zhang, Xiaomin Liu, Yatong Qin, Xinyi Li, Hehe Xiong, Zijian Zhou, Jingjing Zhang and Xiaoyuan Chen
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 739-747; DOI: https://doi.org/10.2967/jnumed.124.268959
    • SPECIAL CONTRIBUTION

      • Open Access
        Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
        Lidia Strigari, Jazmin Schwarz, Tyler Bradshaw, Julia Brosch-Lenz, Geoffrey Currie, Georges El-Fakhri, Abhinav K. Jha, Signe Mežinska, Neeta Pandit-Taskar, Emilie Roncali, Kuangyu Shi, Carlos Uribe, Tahir Yusufaly, Habib Zaidi, Arman Rahmim and Babak Saboury
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 748-756; DOI: https://doi.org/10.2967/jnumed.124.268186

Special Contribution

  • You have access
    Consensus Nomenclature for Radionuclide Therapy: Initial Recommendations from Nuclear Medicine Global Initiative
    Akram Al-Ibraheem, Andrew M. Scott, Ahmed Saad Abdlkadir, Alexis Vrachimis, Francois Lamoureux, Patricia Bernal Trujillo, Dale L. Bailey, Stuart More, Francesco Giammarile, Rakesh Kumar, Julie Nonnekens, Cathy S. Cutler, Jean-Luc C. Urbain, Elizabeth H. Dibble, Mike Machaba Sathekge, Jamshed Bomanji, Juliano J. Cerci, Elizabeth Thomas, William Small, Lizette Louw, Joo Hyun O, Sze Ting Lee, Helen Nadel, Heather Jacene, Tadashi Watabe, Henry Hee-Seung Bom, Salah Eddine Bouyoucef, Charlotte Weston, Jonathan Wadsley, Andy G. Irwin, Jilly Croasdale, Pat Zanzonico, Diana Paez and Munir Ghesani
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 757-763; DOI: https://doi.org/10.2967/jnumed.124.269215

Neurology

  • Clinical

    • Validating the Utility of Supervised Clustering Algorithm for Precise [<sup>11</sup>C]DPA-713 PET Brain Image Quantification
      Open Access
      Validating the Utility of Supervised Clustering Algorithm for Precise [11C]DPA-713 PET Brain Image Quantification
      Youjin Lee, Thanh D. Nguyen, Yong Du, Jennifer M. Coughlin, Sara A. Zein, Nicolas A. Karakatsanis, Sadek Nehmeh, Martin G. Pomper, Susan A. Gauthier and Yeona Kang
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 764-770; DOI: https://doi.org/10.2967/jnumed.124.268519

Radiobiology/Dosimetry

  • Clinical

    • Assessment of [<sup>177</sup>Lu]Lu-DOTATATE Dosimetry from High-Speed Whole-Body Recordings Provided by a 360° Cadmium–Zinc–Telluride Camera Compared with Results from a Conventional Anger-Camera Protocol
      You have access
      Assessment of [177Lu]Lu-DOTATATE Dosimetry from High-Speed Whole-Body Recordings Provided by a 360° Cadmium–Zinc–Telluride Camera Compared with Results from a Conventional Anger-Camera Protocol
      Timothée Zaragori, Elodie Chevalier, Quentin Citerne, Véronique Roch, Gabriela Hossu, Pierre-Yves Marie, Caroline Boursier and Laetitia Imbert
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 771-777; DOI: https://doi.org/10.2967/jnumed.124.268910
    • Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning
      Open Access
      Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning
      Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima and Kuangyu Shi
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 778-784; DOI: https://doi.org/10.2967/jnumed.124.268175
  • Basic

    • FEATURED ARTICLE OF THE MONTH

      • MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy
        Open Access
        MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy
        Julie Constanzo, Aliasghar Parach, Timothee David, Joshua Karam, Frank Bruchertseifer, Alfred Morgenstern, Marta Jarlier, Manuel Bardiès, Emmanuel Deshayes, Amelie Gudin-de-Vallerin, Florence Boissière-Michot, Evelyne Lopez-Crapez and Jean-Pierre Pouget
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 785-792; DOI: https://doi.org/10.2967/jnumed.124.268857
    • INVITED PERSPECTIVE

      • You have access
        Synergy Between Radiopharmaceutical Therapy and Immune Response: Deciphering the Underpinning Mechanisms for Future Actions
        Elif Hindié and Ravi B. Patel
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 793-794; DOI: https://doi.org/10.2967/jnumed.125.269644

AI/Advanced Image Analysis

  • Clinical

    • The Use of Maximum-Intensity Projections and Deep Learning Adds Value to the Fully Automatic Segmentation of Lesions Avid for [<sup>18</sup>F]FDG and [<sup>68</sup>Ga]Ga-PSMA in PET/CT
      You have access
      The Use of Maximum-Intensity Projections and Deep Learning Adds Value to the Fully Automatic Segmentation of Lesions Avid for [18F]FDG and [68Ga]Ga-PSMA in PET/CT
      Cláudia S. Constantino, Francisco P.M. Oliveira, Marisa Machado, Susana Vinga and Durval C. Costa
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 795-801; DOI: https://doi.org/10.2967/jnumed.124.269067
    • BRIEF COMMUNICATION

      • Measuring Total Metabolic Tumor Volume from <sup>18</sup>F-FDG PET: A Reality Check
        You have access
        Measuring Total Metabolic Tumor Volume from 18F-FDG PET: A Reality Check
        Ronald Boellaard, Gerben J.C. Zwezerijnen, Irène Buvat, Laurence Champion, Narinée Hovhannisyan-Baghdasarian, Fanny Orlhac, Anne I.J. Arens, Daphne Lobeek, Filiz Celik, Cristina Mitea, Julia E. Huijbregts, Nelleke Tolboom, Bart de Keizer, Roelf Valkema, Floris H.P. van Velden, Petra Dibbets-Schneider, Sanne E. Wiegers, Pieternella J. Lugtenburg, Sally F. Barrington and Josée M. Zijlstra
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 802-805; DOI: https://doi.org/10.2967/jnumed.124.269271

Radiochemistry/Radiopharmaceuticals

  • Basic

    • Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model
      Open Access
      Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model
      Marian Meckel, Stefanie Ehrenberg, Theresa Schmidt, Philipp Ritt, Margret I. Moré, Ralf Bergmann, Domokos Mathe and Konstantin Zhernosekov
      Journal of Nuclear Medicine May 1, 2025, 66 (5) 806-812; DOI: https://doi.org/10.2967/jnumed.124.268411

Molecular Imaging

  • Basic

    • BRIEF COMMUNICATION

      • Bioanalytic Hybrid System Merging 3-Dimensional Cell Culture and Chromatographic Precision for Unprecedented Preclinical Insights in Molecular Imaging
        Open Access
        Bioanalytic Hybrid System Merging 3-Dimensional Cell Culture and Chromatographic Precision for Unprecedented Preclinical Insights in Molecular Imaging
        Verena Pichler, Verena Schwingenschlögl-Maisetschläger, Irem Duman, Xavier Monforte, Stefanie Ponti, Lukas Zimmermann, Elma Joldic, Monika Dumanic, Chrysoula Vraka, Marcus Hacker, Christian Kraule and Andreas Herbert Teuschl-Woller
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 813-816; DOI: https://doi.org/10.2967/jnumed.124.269133
    • BRIEF COMMUNICATION

      • Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System
        You have access
        Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System
        Edwin C. Pratt, Travis M. Shaffer, David Bauer, Jason S. Lewis and Jan Grimm
        Journal of Nuclear Medicine May 1, 2025, 66 (5) 817-821; DOI: https://doi.org/10.2967/jnumed.124.268806

The Illustrated Post

  • You have access
    Evaluating Bone Healing with [18F]NaF PET/CT During Bone Segment Transport in Femoral Fracture Treatment
    Nick D. van Rijsewijk, Philipp Lanz, Marjan Wouthuyzen-Bakker, Andor W.J.M. Glaudemans and Frank F.A. IJpma
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 822-823; DOI: https://doi.org/10.2967/jnumed.124.268913

Letters to the Editor

  • Open Access
    Determining PSMA-617 Mass and Molar Activity in Pluvicto Doses
    Ivan E. Wang, Allen F. Brooks, Peter J. Scott and Benjamin L. Viglianti
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 824; DOI: https://doi.org/10.2967/jnumed.124.269111
  • You have access
    The Value of Functional PET in Quantifying Neurotransmitter Dynamics
    Murray B. Reed, Matej Murgaš, Rupert Lanzenberger and Andreas Hahn
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 824-825; DOI: https://doi.org/10.2967/jnumed.124.269238
  • You have access
    Reply to “The Value of Functional PET in Quantifying Neurotransmitter Dynamics”
    Evan D. Morris, Gaelle M. Emvalomenos, Jocelyn Hoye and Steven R. Meikle
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 825-827; DOI: https://doi.org/10.2967/jnumed.125.269473

Department

  • You have access
    Errata
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 828; DOI: https://doi.org/10.2967/jnumed.124.665errata
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)

Issue highlights

  • 177Lu-DOTATATE in Combination with PARP Inhibitor Olaparib Is Feasible in Patients with Somatostatin-Positive Tumors: Results from the LuPARP Phase I Trial
  • MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy
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  • Hot Topics
  • Focus on Molecular Imaging
  • Is It Really Happening?
  • Editorial
  • Oncology
    • Clinical
  • Theranostics
    • Clinical
      • FEATURED CLINICAL INVESTIGATION ARTICLE
      • SPECIAL CONTRIBUTION
  • Special Contribution
  • Neurology
    • Clinical
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    • Clinical
    • Basic
      • FEATURED ARTICLE OF THE MONTH
      • INVITED PERSPECTIVE
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    • Clinical
      • BRIEF COMMUNICATION
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  • The Illustrated Post
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  • MIRD Pamphlet No. 28, Part 1: MIRDcalc—A Software Tool for Medical Internal Radiation Dosimetry
  • Absorbed Dose–Response Relationship in Patients with Gastroenteropancreatic Neuroendocrine Tumors Treated with [177Lu]Lu-DOTATATE: One Step Closer to Personalized Medicine
  • Prediction of 177Lu-DOTATATE PRRT Outcome Using Multimodality Imaging in Patients with Gastroenteropancreatic Neuroendocrine Tumors: Results from a Prospective Phase II LUMEN Study
  • Renal and Multiorgan Safety of 177Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer in the VISION Dosimetry Substudy
  • High-Temporal-Resolution Lung Kinetic Modeling Using Total-Body Dynamic PET with Time-Delay and Dispersion Corrections
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