Journal of Nuclear Medicine: 66 (5)

May 1, 2025; Volume 66,Issue 5

The State of the Art

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Treatment Landscape of Prostate Cancer in the Era of PSMA Radiopharmaceutical Therapy
Fabio Turco, Silke Gillessen, Ken Herrmann, Gaetano Paone and Aurelius Omlin

Journal of Nuclear Medicine May 1, 2025, 66 (5) 665-672; DOI: https://doi.org/10.2967/jnumed.124.267730

Hot Topics

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RECIP 1.0: A Roadmap for Clinical Implementation
Andrei Gafita, Loic Djaileb, Jeremie Calais, Matthias Eiber and Wolfgang P. Fendler

Journal of Nuclear Medicine May 1, 2025, 66 (5) 673-675; DOI: https://doi.org/10.2967/jnumed.124.268730

Focus on Molecular Imaging

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Imaging the Activity of Efflux Transporters at the Blood–Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria
Nicolas Tournier and Oliver Langer

Journal of Nuclear Medicine May 1, 2025, 66 (5) 676-680; DOI: https://doi.org/10.2967/jnumed.124.269322

Is It Really Happening?

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Is ²¹¹At Really Happening?
Richard Zimmermann

Journal of Nuclear Medicine May 1, 2025, 66 (5) 681-683; DOI: https://doi.org/10.2967/jnumed.125.269699

Editorial

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A Brief Report on the Results of the 2024 National Survey of Nuclear Medicine Conducted by the Chinese Society of Nuclear Medicine
Jing Wang, Xiaoli Lan, Hongcheng Shi and Sijin Li

Journal of Nuclear Medicine May 1, 2025, 66 (5) 684-685; DOI: https://doi.org/10.2967/jnumed.124.269044

Oncology

Clinical
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  Tumor Asphericity in FDG PET Is an Independent Prognostic Parameter Improving Risk Stratification in Patients with Head and Neck Squamous Cell Carcinoma
  Patrick Hausmann, Sebastian Zschaeck, Christian Furth, Pavel Nikulin, Paulina Cegla, Siyer Roohani, Elia Lombardo, Joanna Kazmierska, Nathalie L. Albert, Adrien Holzgreve, Iosif Strouthos, Claus Belka, Guillaume Landry, Witold Cholewinski, Jorg Kotzerke, Michael Baumann, Mechthild Krause, Daniel Zips, Jörg van den Hoff and Frank Hofheinz
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 686-691; DOI: https://doi.org/10.2967/jnumed.124.268972
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  ¹⁸F-Fluoroestradiol PET/CT for Predicting Benefit from Endocrine Therapy in Patients with Estrogen Receptor–Positive Breast Cancer: A Systematic Review and Metaanalysis
  Ashwin Singh Parihar, Sofia Vaz, Siobhan Sutcliffe, Niharika Pant, Jan W. Schoones and Gary A. Ulaner
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 692-699; DOI: https://doi.org/10.2967/jnumed.124.269163
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  Diagnostic Potential of ⁶⁸Ga-NeoB PET/CT with Estrogen Receptor– and Progesterone Receptor–Positive Breast Cancer Undergoing Staging or Restaging for Metastatic Disease
  Zahra Sabahi, Andrew Nguyen, Keith Wong, Sherrington Li, Nathan Papa, Elgene Lim, Rachel F. Dear, Alexander M. Menzies, Frances Boyle, Yoland Antill, Belinda E. Kiely, Benjamin C. Forster, Cindy Mak, Diana Adams, Lina Pugliano, Andrew Spillane, Shikha Sharma, Adam Hickey, Aron Poole, Shikha Agrawal, Sobia Khan, Narjess Ayati and Louise Emmett
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 700-706; DOI: https://doi.org/10.2967/jnumed.124.268896

Theranostics

Clinical
- FEATURED CLINICAL INVESTIGATION ARTICLE
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    ¹⁷⁷Lu-DOTATATE in Combination with PARP Inhibitor Olaparib Is Feasible in Patients with Somatostatin-Positive Tumors: Results from the LuPARP Phase I Trial
    Andreas Hallqvist, Elva Brynjarsdóttir, Tomas Krantz, Marie Sjögren, Johanna Svensson and Peter Bernhardt
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 707-712; DOI: https://doi.org/10.2967/jnumed.124.268902
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  Prevalence and Medium-Term Outcomes of Patients with Biopsy-Proven Intermediate- to High-Risk Prostate Adenocarcinoma with Low Intraprostatic Uptake on [⁶⁸Ga]Ga-PSMA-11 PET/CT in the proPSMA Study
  David C. Chen, James P. Buteau, Louise Emmett, Ramin Alipour, Felipe de Galiza Barbosa, Matthew J. Roberts, Aoife McVey, Jonathan O’Brien, Sidney Levy, Roslyn J. Francis, Nathan Lawrentschuk, Declan G. Murphy and Michael S. Hofman
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 713-718; DOI: https://doi.org/10.2967/jnumed.124.268901
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  Additive Value of [⁶⁸Ga]Ga-RM26 PET/CT to [⁶⁸Ga]Ga-PSMA-617 PET/CT in Detecting Pelvic Lymph Node Metastasis in Prostate Cancer: A Prospective, Single-Center, Phase II Study
  Wei Tang, Lin Qi, Minfeng Chen, Ye Zhang, Yongxiang Tang, Shuo Hu, Xiaomei Gao and Yi Cai
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 719-725; DOI: https://doi.org/10.2967/jnumed.124.269189
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  PET- and CT-Based Imaging Criteria for Response Assessment of Gastroenteropancreatic Neuroendocrine Tumors Under Radiopharmaceutical Therapy
  Felix L. Herr, Christian Dascalescu, Matthias P. Fabritius, Gabriel T. Sheikh, Mathias J. Zacherl, Vera Wenter, Lena M. Unterrainer, Matthias Brendel, Adrien Holzgreve, Christoph J. Auernhammer, Christine Spitzweg, Tanja Burkard, Jens Ricke, Maurice M. Heimer and Clemens C. Cyran
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 726-731; DOI: https://doi.org/10.2967/jnumed.124.268621
- Open Access
  First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen–Targeted ²¹²Pb Radioligand, in Patients with Metastatic Castration-Resistant Prostate Cancer
  Kjetil Berner, Eivor Hernes, Monika Kvassheim, Mona-Elisabeth Revheim, Julie Bastiansen, Silje Selboe, Charlotte L. Bakken, Simen R. Grønningsæter, Øyvind S. Bruland, Roy H. Larsen, Lily Bouzelmat, Vicki L. Jardine and Caroline Stokke
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 732-738; DOI: https://doi.org/10.2967/jnumed.124.269299
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  Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives ⁶⁸Ga/¹⁷⁷Lu-LNC1011 as Prostate Cancer Theranostics
  Hongzhang Yang, Jiarou Wang, Xuejun Wen, Huifeng Guo, Vivianne Jakobsson, Tianzhi Zhao, Fantian Zeng, Huaxiang Shen, Heng Zhang, Xiaomin Liu, Yatong Qin, Xinyi Li, Hehe Xiong, Zijian Zhou, Jingjing Zhang and Xiaoyuan Chen
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 739-747; DOI: https://doi.org/10.2967/jnumed.124.268959
- SPECIAL CONTRIBUTION
  - Open Access
    Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
    Lidia Strigari, Jazmin Schwarz, Tyler Bradshaw, Julia Brosch-Lenz, Geoffrey Currie, Georges El-Fakhri, Abhinav K. Jha, Signe Mežinska, Neeta Pandit-Taskar, Emilie Roncali, Kuangyu Shi, Carlos Uribe, Tahir Yusufaly, Habib Zaidi, Arman Rahmim and Babak Saboury
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 748-756; DOI: https://doi.org/10.2967/jnumed.124.268186

Special Contribution

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Consensus Nomenclature for Radionuclide Therapy: Initial Recommendations from Nuclear Medicine Global Initiative
Akram Al-Ibraheem, Andrew M. Scott, Ahmed Saad Abdlkadir, Alexis Vrachimis, Francois Lamoureux, Patricia Bernal Trujillo, Dale L. Bailey, Stuart More, Francesco Giammarile, Rakesh Kumar, Julie Nonnekens, Cathy S. Cutler, Jean-Luc C. Urbain, Elizabeth H. Dibble, Mike Machaba Sathekge, Jamshed Bomanji, Juliano J. Cerci, Elizabeth Thomas, William Small, Lizette Louw, Joo Hyun O, Sze Ting Lee, Helen Nadel, Heather Jacene, Tadashi Watabe, Henry Hee-Seung Bom, Salah Eddine Bouyoucef, Charlotte Weston, Jonathan Wadsley, Andy G. Irwin, Jilly Croasdale, Pat Zanzonico, Diana Paez and Munir Ghesani

Journal of Nuclear Medicine May 1, 2025, 66 (5) 757-763; DOI: https://doi.org/10.2967/jnumed.124.269215

Neurology

Clinical
- Open Access
  Validating the Utility of Supervised Clustering Algorithm for Precise [¹¹C]DPA-713 PET Brain Image Quantification
  Youjin Lee, Thanh D. Nguyen, Yong Du, Jennifer M. Coughlin, Sara A. Zein, Nicolas A. Karakatsanis, Sadek Nehmeh, Martin G. Pomper, Susan A. Gauthier and Yeona Kang
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 764-770; DOI: https://doi.org/10.2967/jnumed.124.268519

Radiobiology/Dosimetry

Clinical
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  Assessment of [¹⁷⁷Lu]Lu-DOTATATE Dosimetry from High-Speed Whole-Body Recordings Provided by a 360° Cadmium–Zinc–Telluride Camera Compared with Results from a Conventional Anger-Camera Protocol
  Timothée Zaragori, Elodie Chevalier, Quentin Citerne, Véronique Roch, Gabriela Hossu, Pierre-Yves Marie, Caroline Boursier and Laetitia Imbert
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 771-777; DOI: https://doi.org/10.2967/jnumed.124.268910
- Open Access
  Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning
  Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima and Kuangyu Shi
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 778-784; DOI: https://doi.org/10.2967/jnumed.124.268175
Basic
- FEATURED ARTICLE OF THE MONTH
  - Open Access
    MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy
    Julie Constanzo, Aliasghar Parach, Timothee David, Joshua Karam, Frank Bruchertseifer, Alfred Morgenstern, Marta Jarlier, Manuel Bardiès, Emmanuel Deshayes, Amelie Gudin-de-Vallerin, Florence Boissière-Michot, Evelyne Lopez-Crapez and Jean-Pierre Pouget
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 785-792; DOI: https://doi.org/10.2967/jnumed.124.268857
- INVITED PERSPECTIVE
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    Synergy Between Radiopharmaceutical Therapy and Immune Response: Deciphering the Underpinning Mechanisms for Future Actions
    Elif Hindié and Ravi B. Patel
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 793-794; DOI: https://doi.org/10.2967/jnumed.125.269644

AI/Advanced Image Analysis

Clinical
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  The Use of Maximum-Intensity Projections and Deep Learning Adds Value to the Fully Automatic Segmentation of Lesions Avid for [¹⁸F]FDG and [⁶⁸Ga]Ga-PSMA in PET/CT
  Cláudia S. Constantino, Francisco P.M. Oliveira, Marisa Machado, Susana Vinga and Durval C. Costa
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 795-801; DOI: https://doi.org/10.2967/jnumed.124.269067
- BRIEF COMMUNICATION
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    Measuring Total Metabolic Tumor Volume from ¹⁸F-FDG PET: A Reality Check
    Ronald Boellaard, Gerben J.C. Zwezerijnen, Irène Buvat, Laurence Champion, Narinée Hovhannisyan-Baghdasarian, Fanny Orlhac, Anne I.J. Arens, Daphne Lobeek, Filiz Celik, Cristina Mitea, Julia E. Huijbregts, Nelleke Tolboom, Bart de Keizer, Roelf Valkema, Floris H.P. van Velden, Petra Dibbets-Schneider, Sanne E. Wiegers, Pieternella J. Lugtenburg, Sally F. Barrington and Josée M. Zijlstra
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 802-805; DOI: https://doi.org/10.2967/jnumed.124.269271

Radiochemistry/Radiopharmaceuticals

Basic
- Open Access
  Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model
  Marian Meckel, Stefanie Ehrenberg, Theresa Schmidt, Philipp Ritt, Margret I. Moré, Ralf Bergmann, Domokos Mathe and Konstantin Zhernosekov
  
  Journal of Nuclear Medicine May 1, 2025, 66 (5) 806-812; DOI: https://doi.org/10.2967/jnumed.124.268411

Molecular Imaging

Basic
- BRIEF COMMUNICATION
  - Open Access
    Bioanalytic Hybrid System Merging 3-Dimensional Cell Culture and Chromatographic Precision for Unprecedented Preclinical Insights in Molecular Imaging
    Verena Pichler, Verena Schwingenschlögl-Maisetschläger, Irem Duman, Xavier Monforte, Stefanie Ponti, Lukas Zimmermann, Elma Joldic, Monika Dumanic, Chrysoula Vraka, Marcus Hacker, Christian Kraule and Andreas Herbert Teuschl-Woller
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 813-816; DOI: https://doi.org/10.2967/jnumed.124.269133
- BRIEF COMMUNICATION
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    Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System
    Edwin C. Pratt, Travis M. Shaffer, David Bauer, Jason S. Lewis and Jan Grimm
    
    Journal of Nuclear Medicine May 1, 2025, 66 (5) 817-821; DOI: https://doi.org/10.2967/jnumed.124.268806

The Illustrated Post

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Evaluating Bone Healing with [¹⁸F]NaF PET/CT During Bone Segment Transport in Femoral Fracture Treatment
Nick D. van Rijsewijk, Philipp Lanz, Marjan Wouthuyzen-Bakker, Andor W.J.M. Glaudemans and Frank F.A. IJpma

Journal of Nuclear Medicine May 1, 2025, 66 (5) 822-823; DOI: https://doi.org/10.2967/jnumed.124.268913

Letters to the Editor

Open Access
Determining PSMA-617 Mass and Molar Activity in Pluvicto Doses
Ivan E. Wang, Allen F. Brooks, Peter J. Scott and Benjamin L. Viglianti

Journal of Nuclear Medicine May 1, 2025, 66 (5) 824; DOI: https://doi.org/10.2967/jnumed.124.269111
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The Value of Functional PET in Quantifying Neurotransmitter Dynamics
Murray B. Reed, Matej Murgaš, Rupert Lanzenberger and Andreas Hahn

Journal of Nuclear Medicine May 1, 2025, 66 (5) 824-825; DOI: https://doi.org/10.2967/jnumed.124.269238
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Reply to “The Value of Functional PET in Quantifying Neurotransmitter Dynamics”
Evan D. Morris, Gaelle M. Emvalomenos, Jocelyn Hoye and Steven R. Meikle

Journal of Nuclear Medicine May 1, 2025, 66 (5) 825-827; DOI: https://doi.org/10.2967/jnumed.125.269473

Department

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Errata
Journal of Nuclear Medicine May 1, 2025, 66 (5) 828; DOI: https://doi.org/10.2967/jnumed.124.665errata

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Table of Contents

The State of the Art

Hot Topics

Focus on Molecular Imaging

Is It Really Happening?

Editorial

Oncology

Clinical

Theranostics

Clinical

FEATURED CLINICAL INVESTIGATION ARTICLE

SPECIAL CONTRIBUTION

Special Contribution

Neurology

Clinical

Radiobiology/Dosimetry

Clinical

Basic

FEATURED ARTICLE OF THE MONTH

INVITED PERSPECTIVE

AI/Advanced Image Analysis

Clinical

BRIEF COMMUNICATION

Radiochemistry/Radiopharmaceuticals

Basic

Molecular Imaging

Basic

BRIEF COMMUNICATION

BRIEF COMMUNICATION

The Illustrated Post

Letters to the Editor

Department

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