Clinical Trial Protocol for LuCAB: A Phase I–II Trial Evaluating Cabazitaxel in Combination with [177Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer

Louise Kostos; James P. Buteau; Grace Kong; Ben Tran; Mohammad B. Haskali; Michael Fahey; Megan Crumbaker; Louise Emmett; Michael S. Hofman; Arun A. Azad

doi:10.2967/jnumed.124.269252

Research ArticleClinical Investigation

Clinical Trial Protocol for LuCAB: A Phase I–II Trial Evaluating Cabazitaxel in Combination with [¹⁷⁷Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer

Louise Kostos, James P. Buteau, Grace Kong, Ben Tran, Mohammad B. Haskali, Michael Fahey, Megan Crumbaker, Louise Emmett, Michael S. Hofman and Arun A. Azad

Journal of Nuclear Medicine April 2025, 66 (4) 572-578; DOI: https://doi.org/10.2967/jnumed.124.269252

Louise Kostos

1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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James P. Buteau

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

3Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Grace Kong

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

3Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Ben Tran

1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Mohammad B. Haskali

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

3Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

4Radiopharmaceutical Production and Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Michael Fahey

5Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Megan Crumbaker

6Department of Medical Oncology, Kinghorn Cancer Centre, St Vincent’s Hospital, Sydney, New South Wales, Australia;

7Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

9St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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Louise Emmett

7Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

8Department of Theranostics and Nuclear Medicine, St Vincent’s Hospital, Sydney, New South Wales, Australia; and

9St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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Michael S. Hofman

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

3Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Arun A. Azad

1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Journal of Nuclear Medicine

Vol. 66, Issue 4

April 1, 2025

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Clinical Trial Protocol for LuCAB: A Phase I–II Trial Evaluating Cabazitaxel in Combination with [¹⁷⁷Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer

Louise Kostos, James P. Buteau, Grace Kong, Ben Tran, Mohammad B. Haskali, Michael Fahey, Megan Crumbaker, Louise Emmett, Michael S. Hofman, Arun A. Azad

Journal of Nuclear Medicine Apr 2025, 66 (4) 572-578; DOI: 10.2967/jnumed.124.269252

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Clinical Trial Protocol for LuCAB: A Phase I–II Trial Evaluating Cabazitaxel in Combination with [¹⁷⁷Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer

Louise Kostos, James P. Buteau, Grace Kong, Ben Tran, Mohammad B. Haskali, Michael Fahey, Megan Crumbaker, Louise Emmett, Michael S. Hofman, Arun A. Azad

Journal of Nuclear Medicine Apr 2025, 66 (4) 572-578; DOI: 10.2967/jnumed.124.269252

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Keywords

prostate cancer
combination therapy
PSMA
177Lu
radiopharmaceutical therapy
theranostics

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