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OtherClinical Investigations

Methods to Monitor Response to Chemotherapy in Non-Small Cell Lung Cancer with 18F-FDG PET

Corneline J. Hoekstra, Otto S. Hoekstra, Sigrid G. Stroobants, Johan Vansteenkiste, Johan Nuyts, Egbert F. Smit, Maarten Boers, Jos W.R. Twisk and Adriaan A. Lammertsma
Journal of Nuclear Medicine October 2002, 43 (10) 1304-1309;
Corneline J. Hoekstra
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Otto S. Hoekstra
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Sigrid G. Stroobants
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Johan Vansteenkiste
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Johan Nuyts
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Egbert F. Smit
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Maarten Boers
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Jos W.R. Twisk
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Adriaan A. Lammertsma
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    FIGURE 1.

    Scatter plots of correlation between NLR and SUVBSAg (A), simplified kinetic method (B), and Patlak graphical analysis (C).

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    TABLE 1

    Comparison of Glucose Consumption Measurements with Analytic Methods by Regression Analysis with Those of NLR

    Methodr2SlopeSEInterceptSE
    T/N 40–60 min0.71258.107.251.4711.231
    T/N 50–60 min0.70161.917.941.5921.348
    SUVW, 40–60 min0.89830.541.940.7680.332
    SUVWg, 40–60 min0.91034.772.060.0090.356
    SUVLBM, 40–60 min0.84527.012.200.9870.376
    SUVLBMg, 40–60 min0.92530.421.630.3260.279
    SUVBSA, 40–60 min0.914765.544.3822.547.60
    SUVBSAg, 40–60 min0.966*865.430.963.8135.30
    SUVW, 50–60 min0.89832.112.040.7530.349
    SUVWg, 50–60 min0.90836.532.19−0.0390.376
    SUVLBM, 50–60 min0.84628.402.290.9860.392
    SUVLBMg, 50–60 min0.92531.971.720.2960.294
    SUVBSA, 50–60 min0.914804.846.6722.307.99
    SUVBSAg, 50–60 min0.964*909.433.312.7675.71
    Net influx constant (W)0.9101.0270.06100.011
    Net influx constant (BSA)0.966*0.8710.0310.0040.005
    SKM 40–60 min†0.974*0.8930.0280.0070.005
    SKM 50–60 min†0.972*0.8910.0280.0060.005
    Patlak (10–60 min) MRglu0.984*0.9310.0220.0040.004
    Patlak (10–45 min) MRglu0.982*0.9410.0230.0040.004
    Patlak (10–30 min) MRglu0.951*0.9590.0420.0090.007
    Patlak (20–60 min) MRglu0.972*0.9210.0290.0080.005
    Patlak (30–60 min) MRglu0.968*0.8930.0310.0130.005
    TLE (0.5) MRglu‡0.63883.3111.83−4.0952.023
    TLE (0.5) MRglu§0.6190.3180.0470.0410.008
    TLE (0.6) MRglu‡0.65875.8410.33−4.2631.769
    TLE (0.6) MRglu§0.6790.3700.0480.0480.008
    TLE (0.7) MRglu‡0.67667.048.77−4.4021.502
    TLE (0.7) MRglu§0.6990.4510.0560.0530.009
    TLE (0.8) MRglu‡0.67953.716.97−4.1681.194
    TLE (0.8) MRglu§0.8350.5770.0490.0620.008
    TLE (0.9) MRglu‡0.53629.275.14−2.8000.881
    TLE (0.9) MRglu§0.8150.7390.0800.0750.016
    2-ROI, 6-parameter model0.4192.4060.556−0.0730.094
    • ↵* r2 > 0.95.

    • ↵† Simplified kinetic method described by Hunter et al. (17).

    • ↵‡ Total lesion evaluation method described by Wu et al. (14).

    • ↵§ Correlative imaging method described by Zasadny et al. (15).

    • W = body weight; Wg = W plasma glucose; LBM = lean body mass; LBMg = LBM plasma glucose; BSA = body surface area; BSAg = BSA plasma glucose; MRglc = metabolic rate of glucose.

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Journal of Nuclear Medicine: 43 (10)
Journal of Nuclear Medicine
Vol. 43, Issue 10
October 1, 2002
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Methods to Monitor Response to Chemotherapy in Non-Small Cell Lung Cancer with 18F-FDG PET
Corneline J. Hoekstra, Otto S. Hoekstra, Sigrid G. Stroobants, Johan Vansteenkiste, Johan Nuyts, Egbert F. Smit, Maarten Boers, Jos W.R. Twisk, Adriaan A. Lammertsma
Journal of Nuclear Medicine Oct 2002, 43 (10) 1304-1309;

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Methods to Monitor Response to Chemotherapy in Non-Small Cell Lung Cancer with 18F-FDG PET
Corneline J. Hoekstra, Otto S. Hoekstra, Sigrid G. Stroobants, Johan Vansteenkiste, Johan Nuyts, Egbert F. Smit, Maarten Boers, Jos W.R. Twisk, Adriaan A. Lammertsma
Journal of Nuclear Medicine Oct 2002, 43 (10) 1304-1309;
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