Article Figures & Data
Figures
- FIGURE 1.
Reconstructed image resolution of microPET Focus system as function of radial offset from CFOV. (A) FWHM and FWTM of radial, tangential, and axial image resolutions were calculated by linear extrapolation of corresponding profiles extracted from point source images. (B) Volumetric resolution of the Focus compared with the R4.
- FIGURE 2.
NEC rate of mouse (A), rat (B), and monkey (C) phantoms. Peak NEC rate of 645 kcps is reached with setting of 250–750 keV and 6 ns for mouse phantom. With rat phantom, peak NEC rate is 177 kcps with 250–750 keV and 6 ns. With monkey phantom, peak NEC rate is 44 kcps with 350–650 keV and 6 ns. NECR = NEC rate.
- FIGURE 3.
(A) Emission image measured by the Focus. (B) Same phantom as in A scanned by the R4. Diameter of rods was 0.80, 1.00, 1.25, 1.50, 2.00, and 2.50 mm, respectively. Center-to-center distance between adjacent rods was 2 times the rod diameter.
- FIGURE 4.
Coronal image of 18.7-g mouse injected with 17.8 MBq (0.48 mCi) of 11C-CFT. Image corresponds to 50-min acquisition starting at 70 min after injection by summing the last 10 frames of 2-h dynamic study.
- FIGURE 5.
Cardiac-gated study of 363-g Sprague–Dawley rat injected with 35.7 MBq (0.97 mCi) of 18F-FDG. Acquisition time was 30 min started 110 min after injection. Coronal image of heart: (A) gated at end-systole, (B) gated at end-diastole, and (C) nongated.
- FIGURE 6.
Two-hour dynamic imaging of 5.4-kg macaque monkey injected with 166 MBq (4.5 mCi) of 18F-FDOPA. (A) Transverse (top) and coronal (bottom) views of emission images correspond to summed frames of 15–30 (40–120 min after injection). (B) Transmission images of monkey head of same transverse and coronal slices.
Tables
Category Parameter Concorde Focus Concorde P4 Concorde R4 Prototype microPET microPET II Detector Crystal material LSO LSO LSO LSO LSO Crystal size (mm) 1.51 × 1.51 × 10.00 2.2 × 2.2 × 10.0 2.2 × 2.2 × 10.0 2 × 2 × 10 0.975 × 0.975 × 12.500 Crystal pitch (mm) 1.59 2.45 2.45 2.25 1.15 Crystal array 144 (12 × 12) 64 (8 × 8) 64 (8 × 8) 64 (8 × 8) 196 (14 × 14) Photomultiplier tube Hamamatsu R5900-C12 Hamamatsu R5900-C12 Hamamatsu R5900-C12 Philips XP1722, 64 channel Hamamatsu H7546-M64 System No. of detectors 168 168 96 30 90 No. of crystals 24,192 10,752 6,144 1,920 17,640 No. of rings 48 32 32 8 42 No. of crystals/ring 504 336 192 240 420 Ring diameter (cm) 25.8 26.1 14.8 17.2 16.0 Gantry aperture (cm) 22.0 22.0 13.0 16.0 15.3 Axial FOV (cm) 7.6 7.8 7.8 1.8 4.9 Transaxial FOV (cm) 19.00 19.00 9.40 11.25 8.00 Dataset No. of sinograms 3D 2,304 1,024 1,024 64 1,764 2D 95 63 63 Not used 83 Sinogram size 288 × 252 192 × 168 84 × 96 100 × 120 140 × 210 Dataset size (MB) 3D 638 126 33 1.54 207 2D 26.3 7.8 2.0 Not used 9.7 Sampling distance (mm) 0.795 1.225 1.225 1.125 0.575 Phantom type Energy window (keV) Timing window (ns) Scatter fraction (%) Mouse body (3-cm Ø, 7-cm L, volume = 49.5 mL) 250–750 10 19.0 6 19.0 350–650 10 12.8 6 12.7 Rat body (6-cm Ø, 15-cm L, volume = 424 mL) 250–750 10 36.5 6 36.4 350–650 10 27.6 6 27.4 Monkey body (10.1-cm Ø, 40-cm L, volume = 3,205 mL) 250–750 10 57.6 6 58.1 350–650 10 40.9 6 40.9 Ø = diameter; L = length.
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