This Month in JNM

Tyrosine kinase epidermal cancer imaging: Mishani and Hagooly focus on strategies for molecular imaging and quantification of epidermal growth factor receptor–tyrosine kinase in cancer and outline the potential for these techniques in clinical practice.
Page 1199

Significance of kinetic enhancement: Berridge provides perspective on the role of kinetic enhancement in radiopharmaceutical effectiveness and previews an article in this issue of JNM on the effect of radiopharmaceutical-to-serum protein binding on tracer kinetics.
Page 1203

Preoperative PET in head and neck cancer: Rodrigues and colleagues compare optimized whole-body and dedicated high-resolution contrast-enhanced PET/CT protocols and contrast-enhanced CT in preoperative staging of primary squamous cell carcinoma of the head and neck.
Page 1205

PET detection of bone metastases: Putzer and colleagues assess the comparative diagnostic values of CT imaging and somatostatin analog ⁶⁸Ga-DOTATOC PET in early detection of bone metastases from neuroendocrine tumors.
Page 1214

¹¹C-acetate uptake regulation in HCC: Yun and colleagues explore patterns of ¹¹C-acetate and ¹⁸F-FDG uptake on PET/CT and expression of regulatory enzymes related to glycolysis and lipid synthesis in hepatocellular carcinoma.
Page 1222

Receptor mapping with Hypotime: Møller and colleagues describe a method of calculation that uses ¹¹C-WAY washout rather than accumulation on PET to map serotonin 5HT_1A receptors in the human brain.
Page 1229

¹²³I-MIBG and ¹⁸F-FDG in neuroblastoma: Sharp and colleagues assess differences in diagnostic utility of ¹²³I- MIBG scintigraphy and ¹⁸F-FDG PET in patients with stages 1–4 neuroblastoma.
Page 1237

Parkin gene mutations and dopamine: Ribeiro and colleagues use ¹⁸F-fluoro-l-DOPA, ¹¹C-PE2I, and ¹¹C-raclopride PET to characterize patterns of dopaminergic lesions and related clinical manifestations in young-onset Parkinson disease patients with and without mutations of the Parkin gene.
Page 1244

¹⁸F-Flutemetamol PET: Nelissen and colleagues report on a phase 1 study of ¹⁸F-flutemetamol, a thioflavin derivative of Pittsburgh compound B, including brain kinetic modeling, image acquisition optimization, and comparison of brain retention in Alzheimer disease patients and healthy controls.
Page 1251

Altered serotonin transporters in AD: Ouchi and colleagues examine the relationship of clinical depression in early-to-moderate Alzheimer disease to changes in the brain serotoninergic system and glucose metabolism as assessed by ¹¹C-DASB and ¹⁸F-FDG PET.
Page 1260

P-gp activity at the human BBB: Muzi and colleagues expand on previous studies designed to use ¹¹C-verapamil PET to image cyclosporine inhibition of multiple-drug resistance transporter P-glycoprotein activity at the blood–brain barrier in healthy humans.
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Novel translocator protein tracer: Endres and colleagues describe initial PET studies in humans with ¹¹C-DPA-713, a radioligand that binds to translocator proteins with high affinity, and discuss potential applications in assessment of neuroinflammation.
Page 1276

¹¹C-Methionine PET in MI: Morooka and colleagues examine whether ¹¹C-methionine localizes in areas of myocardial infarction after successful reperfusion and assess the potential for PET imaging of the initial processes of remodeling.
Page 1283

Single-shot cardiorenal scintigraphy: Fommei and colleagues explore the hypothesis that a single combined cardiorenal ^99mTc-tetrofosmin scintigraphy study can allow simultaneous investigation of cardiac and renal pathology in cardiovascular patients.
Page 1288

Predictive CAD testing: Shaw and Narula provide an educational overview of risk assessment, predictive accuracy, and economic outcomes for 3 commonly applied cardiac imaging procedures and highlight the potential added value of hybrid imaging.
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Measuring spatial resolution in PET: Lodge and colleagues report on a quality assurance method for measuring spatial resolution in PET, designed to assist in standardization of data collection for enhanced comparison of results, particularly those from multicenter trials.
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TOF PET tumor detectability: Kadrmas and colleagues evaluate the effect of time-of-flight technology on observer performance in detecting and localizing focal warm lesions in noisy PET images acquired in an anthropomorphic phantom.
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Kinetic model for CSF RIT delivery: Lv and colleagues describe a pharmacokinetic model to evaluate the role of kinetic and transport parameters of radioimmunotherapy designed to treat leptomeningeal metastases using antibodies administered directly into the cerebrospinal fluid.
Page 1324

MDR1 influences ⁶⁴Cu-ATSM retention: Liu and colleagues investigate the role of multidrug resistance type 1 protein expression in accumulation and retention of two ⁶⁴C-labeled tracers and discuss the implications for imaging of tumor hypoxia.
Page 1332

SPECT/CT and HER2 expression: McLarty and colleagues describe animal studies on ¹¹¹In-DTPA-pertuzumab SPECT detection of early molecular response to trastuzumab as indicated by HER2 downregulation and of tumor response with decreased numbers of HER2-positive viable tumor cells.
Page 1340

Central nAChR tracer: Valette and colleagues report on in vitro characterization and in vivo primate studies of a novel radioligand for PET imaging of central nicotinic acetylcholine receptors.
Page 1349

Quantitative imaging of angiogenesis: Dobrucki and colleagues report on validation studies of a semiautomated approach for serial quantitative evaluation of peripheral angiogenesis with micro-SPECT/CT.
Page 1356

K-Ras and uptake in thyroid cancer: Prante and colleagues explore molecular mechanisms behind increases in ¹⁸F-FDG uptake on PET imaging in dedifferentiated thyroid cancer, with findings that point to oncogene activation of intracellular signal transduction cascades.
Page 1364

Apoptosis in right ventricular disease: Campian and colleagues study the role of apoptosis in this setting by monitoring disease progression and treatment response with ^99mTc-annexin-V scintigraphy in rats.
Page 1371

Serum protein binding of ¹²³I-IMP: Kuga and colleagues investigate whether amino acid infusion can improve cerebral accumulation of this SPECT tracer by competitive displacement of serum protein binding.
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ON THE COVER

Time-of-flight PET significantly improves observer performance in detecting focal lesions on a noisy background, as illustrated by this ¹⁸F-FDG PET/CT scan of a patient with esophageal cancer and a body mass index of 27. The reconstructions that include time-of-flight information show improved uniformity in the liver and mediastinal region and better delineate the bone marrow in the ribs and spine.

See page 1322.