Research ArticleCLINICAL INVESTIGATIONS

Reference Tissue Models and Blood–Brain Barrier Disruption: Lessons from (R)-[11C]PK11195 in Traumatic Brain Injury

Hedy Folkersma, Ronald Boellaard, W. Peter Vandertop, Reina W. Kloet, Mark Lubberink, Adriaan A. Lammertsma and Bart N.M. van Berckel
Journal of Nuclear Medicine December 2009, 50 (12) 1975-1979; DOI: https://doi.org/10.2967/jnumed.109.067512

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Figures

  • FIGURE 1. 
    FIGURE 1. 

    K1/k2, VT, and BPNDPI in TBI patients at 7–10 d (♦), 1 mo (▪), and 6 mo (▴) after TBI, and in control subjects (○).

  • FIGURE 2. 
    FIGURE 2. 

    BPNDSRTM (A) as function of BPNDPI for thalamus and trauma/penumbra at 1 and 6 mo after TBI; BPNDSRTM (B) and BPNDPI (C) as function of K1/k2; and BPNDSRTM (D) as function of K1/k2 normalized to reference (cerebellum) K1/k2. Circled data points represent low BPNDSRTM (A) because of low K1/k2 ratio (B).

  • FIGURE 3. 
    FIGURE 3. 

    BPNDSRTM (A) as function of BPNDPI; BPNDSRTM (□) and BPNDPI (♦) (B) as function of K1/k2; and BPNDSRTM (C) as function of K1/k2 normalized to reference (cerebellum) K1/k2.

  • FIGURE 4. 
    FIGURE 4. 

    BPNDSRTM (□) and BPNDPI (♦) as function of K1/k2, with K1/k2 of reference tissue fixed to value indicated by arrow. Horizontal lines represent BPNDSRTM and BPNDPI values for case in which K1/k2 is same as that of reference tissue.

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