PT  - JOURNAL ARTICLE
AU  - Folkersma, Hedy
AU  - Boellaard, Ronald
AU  - Vandertop, W. Peter
AU  - Kloet, Reina W.
AU  - Lubberink, Mark
AU  - Lammertsma, Adriaan A.
AU  - van Berckel, Bart N.M.
TI  - Reference Tissue Models and Blood–Brain Barrier Disruption: Lessons from (<em>R</em>)-[<sup>11</sup>C]PK11195 in Traumatic Brain Injury
AID  - 10.2967/jnumed.109.067512
DP  - 2009 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1975--1979
VI  - 50
IP  - 12
4099  - http://jnm.snmjournals.org/content/50/12/1975.short
4100  - http://jnm.snmjournals.org/content/50/12/1975.full
SO  - J Nucl Med2009 Dec 01; 50
AB  - (R)-[11C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[11C]PK11195 studies in traumatic brain injury (TBI), where blood–brain barrier disruptions are likely. Methods: Dynamic (R)-[11C]PK11195 scans were acquired at 3 time points after TBI. Plasma input–derived binding potential (BPNDPI), volume of distribution (VT) and K1/k2, and simplified reference tissue model–derived binding potential (BPNDSRTM) were obtained. Simulations were performed to assess the effect of varying K1/k2. Results: Early after TBI, an increase in VT, but not in BPNDPI, was found. Early K1/k2 correlated with VT and BPNDSRTM but not with BPNDPI. One and 6 mo after TBI, BPNDSRTM correlated with BPNDPI. Conclusion: Early after TBI, (R)-[11C]PK11195 studies should be analyzed using plasma input models.