RT Journal Article
SR Electronic
T1 Reference Tissue Models and Blood–Brain Barrier Disruption: Lessons from (<em>R</em>)-[<sup>11</sup>C]PK11195 in Traumatic Brain Injury
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1975
OP 1979
DO 10.2967/jnumed.109.067512
VO 50
IS 12
A1 Hedy Folkersma
A1 Ronald Boellaard
A1 W. Peter Vandertop
A1 Reina W. Kloet
A1 Mark Lubberink
A1 Adriaan A. Lammertsma
A1 Bart N.M. van Berckel
YR 2009
UL http://jnm.snmjournals.org/content/50/12/1975.abstract
AB (R)-[11C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[11C]PK11195 studies in traumatic brain injury (TBI), where blood–brain barrier disruptions are likely. Methods: Dynamic (R)-[11C]PK11195 scans were acquired at 3 time points after TBI. Plasma input–derived binding potential (BPNDPI), volume of distribution (VT) and K1/k2, and simplified reference tissue model–derived binding potential (BPNDSRTM) were obtained. Simulations were performed to assess the effect of varying K1/k2. Results: Early after TBI, an increase in VT, but not in BPNDPI, was found. Early K1/k2 correlated with VT and BPNDSRTM but not with BPNDPI. One and 6 mo after TBI, BPNDSRTM correlated with BPNDPI. Conclusion: Early after TBI, (R)-[11C]PK11195 studies should be analyzed using plasma input models.