OtherBasic Science Investigations

18F-FDG Kinetics and Gene Expression in Giant Cell Tumors

Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Dirk Koczan, Ludger Bernd, Uwe Haberkorn, Volker Ewerbeck and Hans-Jürgen Thiesen
Journal of Nuclear Medicine September 2004, 45 (9) 1528-1535;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Gene chip data for 5 giant cell tumors. Normalized expression values are presented in descending order. Data are sorted according to median gene expression values for 5 tumor specimens. Three of the genes with high expression values are shown in bold type (small proteoglycan I, Wilms’ tumor-related protein, and RhoA). Cluster analysis was applied to the data and revealed 2 subgroups, consisting of 2 tumors (left 2 columns) and 3 tumors (right 3 columns).

  • FIGURE 2.
    FIGURE 2.

    (A) Correlation of SUV with VEGF-A expression (r = 0.9618; P = 0.0089). (B) Correlation of SUV with Cdc2 expression (r = 0.9392; P = 0.0178).

  • FIGURE 3.
    FIGURE 3.

    (A) Correlation of vessel density (VB) with VEGF-B (r = 0.8716; P = 0.0541). (B) Correlation of vessel density (VB) with cyclin E (r = 0.9885; P = 0.0015).

  • FIGURE 4.
    FIGURE 4.

    (A) Correlation of k3 with sFLT (r = 0.9444; P = 0.0156). (B) Correlation of k3 with HIF-1 (r = 0.9738; P = 0.0051).

  • FIGURE 5.
    FIGURE 5.

    Correlation of fractal dimension (FD) with VEGF-A (r = 0.9707; P = 0.0060).

  • FIGURE 6.
    FIGURE 6.

    Comparison of 2 giant cell tumors with low 18F-FDG uptake and high 18F-FDG uptake. Both images are scaled to the same range (SUV, 0–5.8). (Upper image) Giant cell tumor of right tibia with an 18F-FDG SUV of 2.4. The relative expression value for VEGF-A was 81. (Lower image) Giant cell tumor of left tibia with an 18F-FDG SUV of 5.8. The relative expression value for VEGF-A was 240.

Tables

  • TABLE 1

    Basic Statistical Data for 18F-FDG PET Studies of 19 Giant Cell Tumors*

    ParameterNo. of casesMeanMedianMinimumMaximumSD
    SUV194.8244.6001.7979.3642.250
    VB180.3520.2910.0100.8990.262
    k1180.3400.4420.0800.8650.249
    k2180.4170.3990.0100.9350.285
    k3180.0720.0540.0050.3590.082
    k4180.0060.0020.0000.0290.008
    Fractal dimension181.3051.3191.1361.4860.088

    • ↵* Dynamic data for 60 min were available in 18 cases; a 2-compartment model could be fitted to the data in 17 cases. In 1 case, the input function could not be retrieved from the data, and in 1 case, only static data were available.

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