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Research ArticleRadiochemistry

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging

Achi Haider, Adrienne Müller Herde, Stefanie D. Krämer, Jasmine Varisco, Claudia Keller, Katrin Frauenknecht, Yves P. Auberson, Louisa Temme, Dina Robaa, Wolfgang Sippl, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey
Journal of Nuclear Medicine August 2019, 60 (8) 1167-1173; DOI: https://doi.org/10.2967/jnumed.118.221051
Achi Haider
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
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Adrienne Müller Herde
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
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Stefanie D. Krämer
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
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Jasmine Varisco
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
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Claudia Keller
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
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Katrin Frauenknecht
2Institute of Neuropathology, University of Zurich/University Hospital Zurich, Zurich, Switzerland
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Yves P. Auberson
3Novartis Institutes for BioMedical Research, Basel, Switzerland
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Louisa Temme
4Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany
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Dina Robaa
5Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Halle/Saale, Germany; and
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Wolfgang Sippl
5Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Halle/Saale, Germany; and
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Roger Schibli
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
6Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
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Bernhard Wünsch
4Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany
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Linjing Mu
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
6Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
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Simon M. Ametamey
1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
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Article Information

vol. 60 no. 8 1167-1173
DOI 
https://doi.org/10.2967/jnumed.118.221051
PubMed 
30683765

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication September 28, 2018
  • Accepted for publication December 14, 2018
  • Published online August 1, 2019.

Article Versions

  • previous version (January 25, 2019 - 08:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Achi Haider1,
  2. Adrienne Müller Herde1,
  3. Stefanie D. Krämer1,
  4. Jasmine Varisco1,
  5. Claudia Keller1,
  6. Katrin Frauenknecht2,
  7. Yves P. Auberson3,
  8. Louisa Temme4,
  9. Dina Robaa5,
  10. Wolfgang Sippl5,
  11. Roger Schibli1,6,
  12. Bernhard Wünsch4,
  13. Linjing Mu1,6 and
  14. Simon M. Ametamey1
  1. 1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
  2. 2Institute of Neuropathology, University of Zurich/University Hospital Zurich, Zurich, Switzerland
  3. 3Novartis Institutes for BioMedical Research, Basel, Switzerland
  4. 4Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany
  5. 5Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Halle/Saale, Germany; and
  6. 6Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
  1. For correspondence or reprints contact: Simon M. Ametamey, Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir‐Prelog Weg 4, CH‐8093 Zurich, Switzerland. E-mail: simon.ametamey{at}pharma.ethz.ch
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Journal of Nuclear Medicine: 60 (8)
Journal of Nuclear Medicine
Vol. 60, Issue 8
August 1, 2019
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Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging
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Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging
Achi Haider, Adrienne Müller Herde, Stefanie D. Krämer, Jasmine Varisco, Claudia Keller, Katrin Frauenknecht, Yves P. Auberson, Louisa Temme, Dina Robaa, Wolfgang Sippl, Roger Schibli, Bernhard Wünsch, Linjing Mu, Simon M. Ametamey
Journal of Nuclear Medicine Aug 2019, 60 (8) 1167-1173; DOI: 10.2967/jnumed.118.221051

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Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging
Achi Haider, Adrienne Müller Herde, Stefanie D. Krämer, Jasmine Varisco, Claudia Keller, Katrin Frauenknecht, Yves P. Auberson, Louisa Temme, Dina Robaa, Wolfgang Sippl, Roger Schibli, Bernhard Wünsch, Linjing Mu, Simon M. Ametamey
Journal of Nuclear Medicine Aug 2019, 60 (8) 1167-1173; DOI: 10.2967/jnumed.118.221051
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  • Preclinical Development of 18F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-D-Aspartate Receptors and Its Utility as a Biomarker for Amyotrophic Lateral Sclerosis
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