receptor occupancy

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Preclinical Development of ¹⁸F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-d-Aspartate Receptors and Its Utility as a Biomarker for Amyotrophic Lateral Sclerosis
Hazem Ahmed, Rahel Wallimann, Achi Haider, Vahid Hosseini, Stefan Gruber, Marvin Robledo, Thi A.N. Nguyen, Adrienne Müller Herde, Irina Iten, Claudia Keller, Viola Vogel, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey

Journal of Nuclear Medicine February 1, 2021, 62 (2) 259-265; DOI: https://doi.org/10.2967/jnumed.120.246785
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Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-¹¹C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ₁-Receptor–Targeted PET Imaging
Achi Haider, Adrienne Müller Herde, Stefanie D. Krämer, Jasmine Varisco, Claudia Keller, Katrin Frauenknecht, Yves P. Auberson, Louisa Temme, Dina Robaa, Wolfgang Sippl, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey

Journal of Nuclear Medicine August 1, 2019, 60 (8) 1167-1173; DOI: https://doi.org/10.2967/jnumed.118.221051
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Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor
Achi Haider, Irina Iten, Hazem Ahmed, Adrienne Müller Herde, Stefan Gruber, Stefanie D. Krämer, Claudia Keller, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey

Journal of Nuclear Medicine February 1, 2019, 60 (2) 259-266; DOI: https://doi.org/10.2967/jnumed.118.212134
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Evaluation of ¹¹C-Me-NB1 as a Potential PET Radioligand for Measuring GluN2B-Containing NMDA Receptors, Drug Occupancy, and Receptor Cross Talk
Stefanie D. Krämer, Thomas Betzel, Linjing Mu, Achi Haider, Adrienne Müller Herde, Anna K. Boninsegni, Claudia Keller, Marina Szermerski, Roger Schibli, Bernhard Wünsch and Simon M. Ametamey

Journal of Nuclear Medicine April 1, 2018, 59 (4) 698-703; DOI: https://doi.org/10.2967/jnumed.117.200451
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Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys
Olivier Barret, Jonas Hannestad, David Alagille, Christine Vala, Adriana Tavares, Caroline Papin, Thomas Morley, Krista Fowles, Hsiaoju Lee, John Seibyl, Dominique Tytgat, Marc Laruelle and Gilles Tamagnan

Journal of Nuclear Medicine October 1, 2014, 55 (10) 1712-1718; DOI: https://doi.org/10.2967/jnumed.114.142067
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¹¹C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists
Koenraad J. Van Laere, Sandra M. Sanabria-Bohórquez, David P. Mozley, Donald H. Burns, Terence G. Hamill, Anne Van Hecken, Inge De Lepeleire, Michel Koole, Guy Bormans, Jan de Hoon, Marleen Depré, Kristine Cerchio, John Plalcza, Lingling Han, John Renger, Richard J. Hargreaves and Robert Iannone

Journal of Nuclear Medicine January 1, 2014, 55 (1) 65-72; DOI: https://doi.org/10.2967/jnumed.113.122515

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receptor occupancy