Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

Achi Haider; Irina Iten; Hazem Ahmed; Adrienne Müller Herde; Stefan Gruber; Stefanie D. Krämer; Claudia Keller; Roger Schibli; Bernhard Wünsch; Linjing Mu; Simon M. Ametamey

doi:10.2967/jnumed.118.212134

Research ArticleRadiochemistry

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

Achi Haider, Irina Iten, Hazem Ahmed, Adrienne Müller Herde, Stefan Gruber, Stefanie D. Krämer, Claudia Keller, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey

Journal of Nuclear Medicine February 2019, 60 (2) 259-266; DOI: https://doi.org/10.2967/jnumed.118.212134

Achi Haider

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Irina Iten

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Hazem Ahmed

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Adrienne Müller Herde

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Stefan Gruber

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Stefanie D. Krämer

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Claudia Keller

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Roger Schibli

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

2Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland; and

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Bernhard Wünsch

3Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany

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Linjing Mu

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

2Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland; and

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Simon M. Ametamey

1Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

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Journal of Nuclear Medicine

Vol. 60, Issue 2

February 1, 2019

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Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

Achi Haider, Irina Iten, Hazem Ahmed, Adrienne Müller Herde, Stefan Gruber, Stefanie D. Krämer, Claudia Keller, Roger Schibli, Bernhard Wünsch, Linjing Mu, Simon M. Ametamey

Journal of Nuclear Medicine Feb 2019, 60 (2) 259-266; DOI: 10.2967/jnumed.118.212134

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Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

Achi Haider, Irina Iten, Hazem Ahmed, Adrienne Müller Herde, Stefan Gruber, Stefanie D. Krämer, Claudia Keller, Roger Schibli, Bernhard Wünsch, Linjing Mu, Simon M. Ametamey

Journal of Nuclear Medicine Feb 2019, 60 (2) 259-266; DOI: 10.2967/jnumed.118.212134

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Keywords

NMDA
GluN2B
PET
receptor occupancy
CP101,606

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Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

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