Aptamer-based imaging: Wang and Farokhzad provide an overview of the use of these single-stranded oligonucleotides as targeting ligands and their application in molecular diagnosis and therapy.
Occult primary NET imaging: Schillaci looks at radiopharmaceuticals available for imaging unknown primary neuroendocrine tumors and previews an article in this issue of JNM on the advantages of 18F-DOPA PET/CT in this setting.
Safety of repeated radioembolization: Zarva and colleagues assess the safety of repeated 90Y radioembolization with resin microspheres in patients with extensive primary and secondary liver tumors after failure of first radioembolization.
18F-FDOPA and NETs of unknown origin: Imperiale and colleagues evaluate the performance of 18F-DOPA PET/CT in detecting and further characterizing primary neuroendocrine tumors not seen on other morphologic or functional imaging.
PET/CT vs PET/MR in lung cancer staging: Heusch and colleagues compare a dedicated pulmonary 18F-FDG PET/MR imaging protocol with 18F-FDG PET/CT for primary and locoregional lymph node staging in patients with non–small cell lung cancer.
Preoperative PET and NSCLC: Zeliadt and colleagues examine the real-world effectiveness of PET in avoiding unnecessary surgery in patients newly diagnosed with non–small cell lung cancer.
PET/CT and KRAS mutations: Miles and colleagues explore the potential for multifunctional imaging to provide a signature for V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog gene mutations in human colorectal cancer.
PET/CT in noninfected vascular grafts: Keidar and colleagues describe the incidence and patterns of 18F-FDG uptake over time in noninfected vascular grafts, with a focus on prosthetic material and location.
PET imaging of VAChT: Petrou and colleagues report on human imaging with 18F-FEOBV, a vesamicol derivative that binds selectively to the vesicular acetylcholine transporter, and detail radiation dosimetry, biodistribution, safety, brain kinetics, and quantitative analysis methods.
Monte Carlo dosimetry for SIRT: Petitguillaume and colleagues present a 3D dosimetry technique based on patient-specific data for optimization of personalized Monte Carlo dosimetry in 90Y selective internal radiation therapy for unresectable hepatic cancer.
Tumor texture, SUV, and volume in PET: Orlhac and colleagues investigate texture indices derived from gray-level histograms and their relationship with standardized uptake value, metabolic tumor volume, and total lesion glycolysis in 3 different tumor types.
PET and NMDA receptors: McGinnity and colleagues characterize the kinetic behavior of 18F-GE-179, a novel radioligand that selectively binds to the open/active state of the N-methyl d-aspartate receptor channels, which play a key role in a range of neurologic processes.
PET/CT and HPV+ OPSCC: Subramaniam and colleagues provide an educational overview of the evolving role of 18F-FDG PET/CT in the management of patients with human papilloma virus–positive oropharyngeal squamous cell cancer.
Propranolol and18F-FDG uptake inhibition: Kang and colleagues explore the relationship between activation of β-adrenoceptors and expression of glucose transporter–1 and hexokinase-2 and discuss the potential effects of this relationship on 18F-FDG PET imaging in breast cancer.
Integrin αvβ3 in pancreatic cancer: Trajkovic-Arsic and colleagues report on the unexplored potential of αvβ3 integrin–targeted multimodal molecular imaging for detection of pancreatic ductal adenocarcinoma in genetically engineered mouse models.
ImmunoPET with anti-PSCA minibody: Knowles and colleagues detail the development and validation of agents using 124I- and 89Zr-labeled anti–prostate stem cell antigen A11 minibodies and evaluate their use for quantitative immunoPET imaging of prostate cancer.
Serotonergic metabolism in pancreas: Eriksson and colleagues investigate the feasibility of quantitative noninvasive imaging of serotonergic metabolism in the endocrine pancreas using the PET tracer 11C-5-HTP.
Imaging microglial activation: Dickens and colleagues describe a reproducible lipopolysaccharide-induced model of acute central nervous system inflammation and compare the performance of 18F-GE-180, a translocator protein ligand, with that of 11C-(R)-PK11195 in detection of activated microglial cells and astrocytes.
Imaging MC-I in the brain: Tsukada and colleagues evaluate a novel probe for quantitative PET assessment of mitochondria complex 1 activity and associated ischemic damage in the living brain.
Estrogen receptor imaging in rats: Khayum and colleagues determine whether estrogen receptors can be measured in the rat brain with 18F-FES PET and whether tracer uptake is affected by endogenous estrogen.
Improved complexes for hypoxia imaging: Handley and colleagues report on evaluation and performance of 2 promising 64Cu-ATSM analog complexes for PET imaging of hypoxic myocardium.
Small-animal PET with isolated perfused heart: Yamane and colleagues report on a technique combining the Langendorff method of isolated rat heart perfusion with high-resolution small-animal PET to facilitate reliable quantification of myocardial tracer kinetics.
TEM1 immuno-PET: Chacko and colleagues detail the preparation and evaluation of a novel 124I-labeled humanized monoclonal antibody, looking at its ability to specifically and sensitively detect vascular cells expressing tumor endothelial marker 1 in vivo.
XTEN-annexin A5: Haeckel and colleagues present a method to extend imaging probe blood life with a long-circulating hydrophilic peptide without PEGylation, thereby simplifying synthesis and avoiding inactivation of annexin A5 and potential adverse effects of polyethylene glycol.
Comparison of 4 PET hypoxia tracers: Carlin and colleagues compare the imaging characteristics and hypoxia selectivity of 4 PET radiotracers in a murine xenograft tumor model using small-animal PET imaging and combined ex vivo autoradiography and fluorescence immunohistochemistry.
- © 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
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