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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180

Alex M. Dickens, Susanne Vainio, Päivi Marjamäki, Jarkko Johansson, Paula Lehtiniemi, Johanna Rokka, Juha Rinne, Olof Solin, Merja Haaparanta-Solin, Paul A. Jones, William Trigg, Daniel C. Anthony and Laura Airas
Journal of Nuclear Medicine March 2014, 55 (3) 466-472; DOI: https://doi.org/10.2967/jnumed.113.125625
Alex M. Dickens
1Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland
2MediCity/PET Preclinical Laboratory, University of Turku, Turku, Finland
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Susanne Vainio
2MediCity/PET Preclinical Laboratory, University of Turku, Turku, Finland
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Päivi Marjamäki
2MediCity/PET Preclinical Laboratory, University of Turku, Turku, Finland
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Jarkko Johansson
3Turku PET Centre, University of Turku, Turku, Finland
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Paula Lehtiniemi
4Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku PET Centre, Turku, Finland
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Johanna Rokka
4Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku PET Centre, Turku, Finland
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Juha Rinne
3Turku PET Centre, University of Turku, Turku, Finland
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Olof Solin
4Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku PET Centre, Turku, Finland
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Merja Haaparanta-Solin
2MediCity/PET Preclinical Laboratory, University of Turku, Turku, Finland
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Paul A. Jones
5GE Healthcare Ltd., Amersham, United Kingdom
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William Trigg
5GE Healthcare Ltd., Amersham, United Kingdom
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Daniel C. Anthony
6Department of Pharmacology, University of Oxford, Oxford, United Kingdom; and
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Laura Airas
7Department of Neurology, Turku University Hospital, Turku, Finland
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Journal of Nuclear Medicine: 55 (3)
Journal of Nuclear Medicine
Vol. 55, Issue 3
March 1, 2014
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Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180
Alex M. Dickens, Susanne Vainio, Päivi Marjamäki, Jarkko Johansson, Paula Lehtiniemi, Johanna Rokka, Juha Rinne, Olof Solin, Merja Haaparanta-Solin, Paul A. Jones, William Trigg, Daniel C. Anthony, Laura Airas
Journal of Nuclear Medicine Mar 2014, 55 (3) 466-472; DOI: 10.2967/jnumed.113.125625

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Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180
Alex M. Dickens, Susanne Vainio, Päivi Marjamäki, Jarkko Johansson, Paula Lehtiniemi, Johanna Rokka, Juha Rinne, Olof Solin, Merja Haaparanta-Solin, Paul A. Jones, William Trigg, Daniel C. Anthony, Laura Airas
Journal of Nuclear Medicine Mar 2014, 55 (3) 466-472; DOI: 10.2967/jnumed.113.125625
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Cited By...

  • Pre-therapeutic Microglia Activation and Sex Determine Therapy Effects of Chronic Immunomodulation
  • Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies
  • Sexually dimorphic responses to MPTP found in microglia, inflammation and gut microbiota in a progressive monkey model of Parkinsons disease
  • PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)
  • Imaging microglial activation in tacrolimus-associated CNS vasculitis with translocator protein PET
  • Head-to-Head Comparison of 11C-PBR28 and 18F-GE180 for Quantification of the Translocator Protein in the Human Brain
  • Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease
  • The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism
  • Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein
  • Serial Quantitative TSPO-Targeted PET Reveals Peak Microglial Activation up to 2 Weeks After an Epileptogenic Brain Insult
  • Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study
  • In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice
  • In Vivo PET Imaging Demonstrates Diminished Microglial Activation After Fingolimod Treatment in an Animal Model of Multiple Sclerosis
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More in this TOC Section

  • 11C-Methionine PET of Myocardial Inflammation in a Rat Model of Experimental Autoimmune Myocarditis
  • Counting Rate Characteristics and Image Distortion in Preclinical PET Imaging During Radiopharmaceutical Therapy
  • Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology
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Keywords

  • neuroinflammation
  • Positron Emission Tomography
  • second-generation TSPO ligand
  • brain
  • astrocyte
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