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Research ArticleBasic Science Investigations

Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease

Nobuyuki Okamura, Shozo Furumoto, Ryuichi Harada, Tetsuro Tago, Takeo Yoshikawa, Michelle Fodero-Tavoletti, Rachel S. Mulligan, Victor L. Villemagne, Hiroyasu Akatsu, Takayuki Yamamoto, Hiroyuki Arai, Ren Iwata, Kazuhiko Yanai and Yukitsuka Kudo
Journal of Nuclear Medicine August 2013, 54 (8) 1420-1427; DOI: https://doi.org/10.2967/jnumed.112.117341
Nobuyuki Okamura
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
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Shozo Furumoto
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
2Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Ryuichi Harada
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
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Tetsuro Tago
2Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Takeo Yoshikawa
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
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Michelle Fodero-Tavoletti
3Department of Pathology, University of Melbourne, Victoria, Australia
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Rachel S. Mulligan
4Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Victoria, Australia
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Victor L. Villemagne
4Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Victoria, Australia
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Hiroyasu Akatsu
5Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan
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Takayuki Yamamoto
5Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan
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Hiroyuki Arai
6Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and
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Ren Iwata
2Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Kazuhiko Yanai
1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
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Yukitsuka Kudo
7Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan
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Journal of Nuclear Medicine: 54 (8)
Journal of Nuclear Medicine
Vol. 54, Issue 8
August 1, 2013
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Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease
Nobuyuki Okamura, Shozo Furumoto, Ryuichi Harada, Tetsuro Tago, Takeo Yoshikawa, Michelle Fodero-Tavoletti, Rachel S. Mulligan, Victor L. Villemagne, Hiroyasu Akatsu, Takayuki Yamamoto, Hiroyuki Arai, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo
Journal of Nuclear Medicine Aug 2013, 54 (8) 1420-1427; DOI: 10.2967/jnumed.112.117341

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Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease
Nobuyuki Okamura, Shozo Furumoto, Ryuichi Harada, Tetsuro Tago, Takeo Yoshikawa, Michelle Fodero-Tavoletti, Rachel S. Mulligan, Victor L. Villemagne, Hiroyasu Akatsu, Takayuki Yamamoto, Hiroyuki Arai, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo
Journal of Nuclear Medicine Aug 2013, 54 (8) 1420-1427; DOI: 10.2967/jnumed.112.117341
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Cited By...

  • Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers
  • Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers
  • 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging
  • Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models
  • Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18
  • Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET
  • Biodistribution and Radiation Dosimetry for the Tau Tracer 18F-THK-5351 in Healthy Human Subjects
  • Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules
  • Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects
  • In Vivo Comparison of Tau Radioligands 18F-THK-5351 and 18F-THK-5317
  • Tau Positron Emission Tomography Imaging
  • Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging
  • In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET
  • Kinetics of the Tau PET Tracer 18F-AV-1451 (T807) in Subjects with Normal Cognitive Function, Mild Cognitive Impairment, and Alzheimer Disease
  • Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly
  • In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain
  • Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models
  • Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease
  • Tracer Kinetic Analysis of (S)-18F-THK5117 as a PET Tracer for Assessing Tau Pathology
  • 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
  • Cortical Laminar Binding of PET Amyloid and Tau Tracers in Alzheimer Disease
  • New Targets for the Development of PET Tracers for Imaging Neurodegeneration in Alzheimer Disease
  • Molecular Imaging of Alzheimer Disease Pathology
  • Molecular Imaging Insights into Neurodegeneration: Focus on Tau PET Radiotracers
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More in this TOC Section

  • Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology
  • Synthesis and Biologic Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer
  • Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers
Show more Basic Science Investigations

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Keywords

  • Alzheimer disease
  • tau
  • neurofibrillary tangles
  • Positron Emission Tomography
  • Molecular imaging
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