OtherBasic Science Investigations

Absolute Quantification of Myocardial Blood Flow with H215O and 3-Dimensional PET: An Experimental Validation

Klaus P. Schäfers, Terence J. Spinks, Paolo G. Camici, Peter M. Bloomfield, Christopher G. Rhodes, Marilyn P. Law, Christopher S.R. Baker and Ornella Rimoldi
Journal of Nuclear Medicine August 2002, 43 (8) 1031-1040;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Cluster probability images of transaxial planes and corresponding time-activity curves. (A) Venous cluster (right ventricular cavity). (B) Arterial cluster (left ventricular cavity. (C) Myocardial tissue cluster.

  • FIGURE 2.
    FIGURE 2.

    Short-axis images obtained from representative study show blood pool (A) measured with C15O, which labels erythrocytes through formation of carboxyhemoglobin, and distribution of H215O separated in blood (B) and myocardial tissue (C) component. B and C are calculated by means of factor analysis. RV = right ventricle; LV = left ventricle.

  • FIGURE 3.
    FIGURE 3.

    Regression analysis (A) and Bland-Altman plot (B) of variation of MBF obtained from microspheres and PET in all ROIs. Dashed lines = 95% confidence limits for slope; Diff = difference.

  • FIGURE 4.
    FIGURE 4.

    Bland-Altman plots show agreement of MBF obtained from microspheres and PET under resting conditions (A) and during hyperemia induced with dipyridamole (B). Diff = difference.

  • FIGURE 5.
    FIGURE 5.

    Bland-Altman plots show agreement of MBF obtained from microspheres and PET during hyperemia induced with dipyridamole. Data are presented for group in which left circumflex coronary artery was occluded (A) and for group in which left anterior descending coronary artery was occluded (B). Diff = difference.

  • FIGURE 6.
    FIGURE 6.

    Histogram shows comparison of PTF (A) and PTI (B) in normally perfused (control) and ischemic myocardium. Values of PTF and PTI are reduced during dipyridamole-induced stress (hyperemia) *P < 0.05.

Tables

  • TABLE 1

    Hemodynamic Parameters at Baseline After Inflation of Hydraulic Occluder (Ischemia) and During Dipyridamole Infusion

    Systolic pressure (mm Hg)Diastolic pressure (mm Hg)Heart rate (beats/min)End-diastolic LV pressure (mm Hg)LV dP/dt maximum (mm Hg/s)% Segment shorteningMean coronary blood flow (mL/min)
    Baseline113 ± 1874 ± 1594 ± 209 ± 31,599 ± 31918.16 ± 3.833 ± 13
    Ischemia111 ± 1274 ± 12106 ± 179 ± 41,373 ± 2958.15 ± 2.9*16 ± 10*
    Ischemia + dipyridamole72 ± 8*†38 ± 6*†110 ± 138 ± 41,208 ± 3099.1 ± 3.2*27 ± 12

    • ↵* Significantly different from baseline (P < 0.05).

    • ↵† Ischemia significantly different from ischemia + dipyridamole.

  • TABLE 2

    Comparison of Variance of Difference of MBF Measurement Between Microspheres and PET in Different Regions of Left Ventricle

    BasalMidventricularApex
    Rest
     Anterior0.0050.0380.126 b*
     Lateral0.0120.0310.113 b*
     Septal0.0080.0100.032
     Posterior0.124 a, s, i†0.137 s†
     Inferior0.0070.0340.032
    Hyperemia
     Anterior0.1160.362 l†0.254
     Lateral0.0630.0330.173 m*
     Septal0.1210.0890.096
     Posterior0.1350.579 l, s†
     Inferior0.0790.172 l†0.200

    • ↵* Apical regions significantly different from basal (b) or midventricular (m) regions (P < 0.05).

    • ↵† Significant contrast difference vs. other regions in short-axis partition: a = anterior, l = lateral, s = septal, i = inferior (P < 0.05).

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