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Research ArticlePhysics And Instrumentation

89Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo

Yvonne W.S. Jauw, Joseph A. O’Donoghue, Josée M. Zijlstra, Otto S. Hoekstra, C. Willemien Menke-van der Houven van Oordt, Franck Morschhauser, Jorge A. Carrasquillo, Sonja Zweegman, Neeta Pandit-Taskar, Adriaan A. Lammertsma, Guus. A.M.S. van Dongen, Ronald Boellaard, Wolfgang A. Weber and Marc C. Huisman
Journal of Nuclear Medicine December 2019, 60 (12) 1825-1832; DOI: https://doi.org/10.2967/jnumed.118.224568
Yvonne W.S. Jauw
1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Joseph A. O’Donoghue
3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
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Josée M. Zijlstra
1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Otto S. Hoekstra
2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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C. Willemien Menke-van der Houven van Oordt
4Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Franck Morschhauser
5EA7365-GRITA-Groupe de Recherche sur les forms Injectables et les Technologies Associées, Université de Lille, and Department of Hematology, CHU Lille, Lille, France
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Jorge A. Carrasquillo
6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and
7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York
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Sonja Zweegman
1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Neeta Pandit-Taskar
6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and
7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York
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Adriaan A. Lammertsma
2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Guus. A.M.S. van Dongen
2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Ronald Boellaard
2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Wolfgang A. Weber
6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and
7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York
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Marc C. Huisman
2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Article Information

vol. 60 no. 12 1825-1832
DOI 
https://doi.org/10.2967/jnumed.118.224568
PubMed 
31147401

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 6, 2018
  • Accepted for publication April 8, 2019
  • Published online December 2, 2019.

Article Versions

  • previous version (May 30, 2019 - 14:34).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Yvonne W.S. Jauw1,2,
  2. Joseph A. O’Donoghue3,
  3. Josée M. Zijlstra1,
  4. Otto S. Hoekstra2,
  5. C. Willemien Menke-van der Houven van Oordt4,
  6. Franck Morschhauser5,
  7. Jorge A. Carrasquillo6,7,
  8. Sonja Zweegman1,
  9. Neeta Pandit-Taskar6,7,
  10. Adriaan A. Lammertsma2,
  11. Guus. A.M.S. van Dongen2,
  12. Ronald Boellaard2,
  13. Wolfgang A. Weber6,7 and
  14. Marc C. Huisman2
  1. 1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  2. 2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  3. 3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
  4. 4Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  5. 5EA7365-GRITA-Groupe de Recherche sur les forms Injectables et les Technologies Associées, Université de Lille, and Department of Hematology, CHU Lille, Lille, France
  6. 6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and
  7. 7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York
  1. For correspondence or reprints contact: Yvonne W.S. Jauw, Amsterdam UMC, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. E-mail: yws.jauw{at}vumc.nl
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Journal of Nuclear Medicine: 60 (12)
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89Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo
Yvonne W.S. Jauw, Joseph A. O’Donoghue, Josée M. Zijlstra, Otto S. Hoekstra, C. Willemien Menke-van der Houven van Oordt, Franck Morschhauser, Jorge A. Carrasquillo, Sonja Zweegman, Neeta Pandit-Taskar, Adriaan A. Lammertsma, Guus. A.M.S. van Dongen, Ronald Boellaard, Wolfgang A. Weber, Marc C. Huisman
Journal of Nuclear Medicine Dec 2019, 60 (12) 1825-1832; DOI: 10.2967/jnumed.118.224568

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89Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo
Yvonne W.S. Jauw, Joseph A. O’Donoghue, Josée M. Zijlstra, Otto S. Hoekstra, C. Willemien Menke-van der Houven van Oordt, Franck Morschhauser, Jorge A. Carrasquillo, Sonja Zweegman, Neeta Pandit-Taskar, Adriaan A. Lammertsma, Guus. A.M.S. van Dongen, Ronald Boellaard, Wolfgang A. Weber, Marc C. Huisman
Journal of Nuclear Medicine Dec 2019, 60 (12) 1825-1832; DOI: 10.2967/jnumed.118.224568
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