89Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo

Yvonne W.S. Jauw; Joseph A. O’Donoghue; Josée M. Zijlstra; Otto S. Hoekstra; C. Willemien Menke-van der Houven van Oordt; Franck Morschhauser; Jorge A. Carrasquillo; Sonja Zweegman; Neeta Pandit-Taskar; Adriaan A. Lammertsma; Guus. A.M.S. van Dongen; Ronald Boellaard; Wolfgang A. Weber; Marc C. Huisman

doi:10.2967/jnumed.118.224568

Research ArticlePhysics And Instrumentation

⁸⁹Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo

Yvonne W.S. Jauw, Joseph A. O’Donoghue, Josée M. Zijlstra, Otto S. Hoekstra, C. Willemien Menke-van der Houven van Oordt, Franck Morschhauser, Jorge A. Carrasquillo, Sonja Zweegman, Neeta Pandit-Taskar, Adriaan A. Lammertsma, Guus. A.M.S. van Dongen, Ronald Boellaard, Wolfgang A. Weber and Marc C. Huisman

Journal of Nuclear Medicine December 2019, 60 (12) 1825-1832; DOI: https://doi.org/10.2967/jnumed.118.224568

Yvonne W.S. Jauw

1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Joseph A. O’Donoghue

3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York

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Josée M. Zijlstra

1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Otto S. Hoekstra

2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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C. Willemien Menke-van der Houven van Oordt

4Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Franck Morschhauser

5EA7365-GRITA-Groupe de Recherche sur les forms Injectables et les Technologies Associées, Université de Lille, and Department of Hematology, CHU Lille, Lille, France

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Jorge A. Carrasquillo

6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and

7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York

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Sonja Zweegman

1Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Neeta Pandit-Taskar

6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and

7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York

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Adriaan A. Lammertsma

2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Guus. A.M.S. van Dongen

2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Ronald Boellaard

2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Wolfgang A. Weber

6Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and

7Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York

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Marc C. Huisman

2Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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⁸⁹Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo

Journal of Nuclear Medicine Dec 2019, 60 (12) 1825-1832; DOI: 10.2967/jnumed.118.224568

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⁸⁹Zr-Immuno-PET: Toward a Noninvasive Clinical Tool to Measure Target Engagement of Therapeutic Antibodies In Vivo

Journal of Nuclear Medicine Dec 2019, 60 (12) 1825-1832; DOI: 10.2967/jnumed.118.224568

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Keywords

immuno-PET
Monoclonal Antibodies
89Zr
molecular imaging
positron emission tomography

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