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Journal of Nuclear Medicine

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Research ArticleClinical Investigations

Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein

Chul Hyoung Lyoo, Masamichi Ikawa, Jeih-San Liow, Sami S. Zoghbi, Cheryl L. Morse, Victor W. Pike, Masahiro Fujita, Robert B. Innis and William Charles Kreisl
Journal of Nuclear Medicine May 2015, 56 (5) 701-706; DOI: https://doi.org/10.2967/jnumed.114.146027
Chul Hyoung Lyoo
1Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Masamichi Ikawa
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Jeih-San Liow
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Sami S. Zoghbi
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Cheryl L. Morse
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Victor W. Pike
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Masahiro Fujita
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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Robert B. Innis
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
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William Charles Kreisl
2Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and
3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, New York
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Journal of Nuclear Medicine: 56 (5)
Journal of Nuclear Medicine
Vol. 56, Issue 5
May 1, 2015
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Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein
Chul Hyoung Lyoo, Masamichi Ikawa, Jeih-San Liow, Sami S. Zoghbi, Cheryl L. Morse, Victor W. Pike, Masahiro Fujita, Robert B. Innis, William Charles Kreisl
Journal of Nuclear Medicine May 2015, 56 (5) 701-706; DOI: 10.2967/jnumed.114.146027

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Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein
Chul Hyoung Lyoo, Masamichi Ikawa, Jeih-San Liow, Sami S. Zoghbi, Cheryl L. Morse, Victor W. Pike, Masahiro Fujita, Robert B. Innis, William Charles Kreisl
Journal of Nuclear Medicine May 2015, 56 (5) 701-706; DOI: 10.2967/jnumed.114.146027
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More in this TOC Section

  • Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  • Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
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Keywords

  • Alzheimer disease
  • neuroinflammation
  • 11C-PBR28
  • Positron Emission Tomography
  • ratio method
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