OtherBasic Science Investigations

Rat Studies Comparing 11C-FMAU, 18F-FLT, and 76Br-BFU as Proliferation Markers

Li Lu, Linda Samuelsson, Mats Bergström, Kengo Sato, Karl-Johan Fasth and Bengt Långström
Journal of Nuclear Medicine December 2002, 43 (12) 1688-1698;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Structures of 11C-FMAU, 18F-FLT, and 76Br-BFU.

  • FIGURE 2.
    FIGURE 2.

    (A) Uptake of 11C-FMAU, expressed as SUV (mean ± SD) in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine together with 11C-FMAU or hydroxyurea 30 min before administration of radioactivity. (B) Uptake of 11C-FMAU, expressed as ratio to blood radioactivity concentration (mean ± SD) in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine with 11C-FMAU or hydroxyurea 30 min before administration of radioactivity.

  • FIGURE 3.
    FIGURE 3.

    Fraction of 11C-FMAU radioactivity, expressed as percentage of total tissue radioactivity (mean ± SD), recovered in DNA fraction in rat organs. Different animals were administered cimetidine with 11C-FMAU.

  • FIGURE 4.
    FIGURE 4.

    Uptake of 18F-FLT, expressed as SUV (mean ± SD) in rat organs. Animals were killed after 80 min or 2 or 4 h. Different animals were administered cimetidine with 18F-FLT or hydroxyurea 30 min before administration of radioactivity.

  • FIGURE 5.
    FIGURE 5.

    (A) Uptake of 76Br-BFU, expressed as SUV (mean ± SD), in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine with 76Br-BFU and were killed after 5, 20, 40, 60, or 80 min and 2, 4, 6, or 24 h. (B) Uptake of 76Br-BFU, expressed as ratio to blood radioactivity concentration (mean ± SD) in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine with 76Br-BFU and were sacrificed after 5, 20, 40, 60, or 80 min and 2, 4, 6, or 24 h.

  • FIGURE 6.
    FIGURE 6.

    Fraction of 76Br-BFU radioactivity, expressed as percentage of total tissue radioactivity (mean ± SD), recovered in DNA fraction in rat organs. Different animals were administered cimetidine with 76Br-BFU.

Tables

  • TABLE 1

    Elimination of Radioactivity from Rat Kidney*

    TracerGroupElimination of radioactivity in 5 min (%)Elimination of radioactivity in 80 min (%)
    11C-FMAUUntreated1.33 ± 0.1829.78 ± 3.18
    11C-FMAUCimetidine-treated0.27 ± 0.032.69 ± 0.08
    76Br-BFUUntreated14.93 ± 7.1375.71 ± 6.81
    76Br-BFUCimetidine-treated0.51 ± 0.1819.89 ± 7.23
    18F-FLTUntreated62.43 ± 4.77
    18F-FLTCimetidine-treated40.26 ± 7.35

    • ↵* Expressed as percentage of injected dose (mean ± SD).

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