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Research ArticleGeneral Nuclear Medicine

Copper-62-ATSM: A New Hypoxia Imaging Agent with High Membrane Permeability and Low Redox Potential

Yasuhisa Fujibayashi, Hideyuki Taniuchi, Yoshiharu Yonekura, Hiroshi Ohtani, Junji Konishi and Akira Yokoyama
Journal of Nuclear Medicine July 1997, 38 (7) 1155-1160;
Yasuhisa Fujibayashi
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Hideyuki Taniuchi
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Yoshiharu Yonekura
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Hiroshi Ohtani
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Junji Konishi
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Akira Yokoyama
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Article Information

vol. 38 no. 7 1155-1160
PubMed 
9225812

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X

Copyright & Usage 
COPYRIGHT© 1997 by the Society of Nuclear Medicine, Inc.

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Journal of Nuclear Medicine
Vol. 38, Issue 7
July 1, 1997
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Copper-62-ATSM: A New Hypoxia Imaging Agent with High Membrane Permeability and Low Redox Potential
Yasuhisa Fujibayashi, Hideyuki Taniuchi, Yoshiharu Yonekura, Hiroshi Ohtani, Junji Konishi, Akira Yokoyama
Journal of Nuclear Medicine Jul 1997, 38 (7) 1155-1160;

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Copper-62-ATSM: A New Hypoxia Imaging Agent with High Membrane Permeability and Low Redox Potential
Yasuhisa Fujibayashi, Hideyuki Taniuchi, Yoshiharu Yonekura, Hiroshi Ohtani, Junji Konishi, Akira Yokoyama
Journal of Nuclear Medicine Jul 1997, 38 (7) 1155-1160;
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  • PET/CT in the Evaluation of Hypoxia for Radiotherapy Planning in Head and Neck Tumors: Systematic Literature Review
  • Disrupted copper availability in sporadic ALS: Implications for CuII(atsm) as a treatment option
  • Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia
  • An Overview of PET Radiochemistry, Part 2: Radiometals
  • 64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET
  • Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study
  • Copper Complexation Screen Reveals Compounds with Potent Antibiotic Properties against Methicillin-Resistant Staphylococcus aureus
  • A Comparison of the Imaging Characteristics and Microregional Distribution of 4 Hypoxia PET Tracers
  • 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET
  • A Comparison of the Behavior of 64Cu-Acetate and 64Cu-ATSM In Vitro and In Vivo
  • Copper-Boosting Compounds: a Novel Concept for Antimycobacterial Drug Discovery
  • Application of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET Imaging to Predict Highly Malignant Tumor Grades and Hypoxia-Inducible Factor-1{alpha} Expression in Patients with Glioma
  • PET of Hypoxia: Current and Future Perspectives
  • An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII
  • Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model
  • Imaging hypoxia in gliomas
  • Pathophysiologic Correlation Between 62Cu-ATSM and 18F-FDG in Lung Cancer
  • Retention of the Radiotracers 64Cu-ATSM and 64Cu-PTSM in Human and Murine Tumors Is Influenced by MDR1 Protein Expression
  • Increasing Cu bioavailability inhibits A{beta} oligomers and tau phosphorylation
  • In Vitro and In Vivo Evaluations of a Hydrophilic 64Cu-Bis(Thiosemicarbazonato)-Glucose Conjugate for Hypoxia Imaging
  • An Imaging Comparison of 64Cu-ATSM and 60Cu-ATSM in Cancer of the Uterine Cervix
  • Molecular Imaging of Hypoxia
  • Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-{beta} Peptide
  • PET-Based Treatment Planning in Radiotherapy: A New Standard?
  • 64Cu-Azabicyclo[3.2.2]Nonane Thiosemicarbazone Complexes: Radiopharmaceuticals for PET of Topoisomerase II Expression in Tumors
  • Advanced imaging applied to radiotherapy planning in head and neck cancer: a clinical review.
  • Intertumoral Differences in Hypoxia Selectivity of the PET Imaging Agent 64Cu(II)-Diacetyl-Bis(N4-Methylthiosemicarbazone)
  • Oncologic Imaging in Gynecologic Malignancies
  • Enhancing Targeted Radiotherapy by Copper(II)diacetyl- bis(N4-methylthiosemicarbazone) Using 2-Deoxy-D-Glucose
  • Delineation of Hypoxia in Canine Myocardium Using PET and Copper(II)-Diacetyl-bis(N4-Methylthiosemicarbazone)
  • The Synthesis and Radiolabeling of 2-Nitroimidazole Derivatives of Cyclam and Their Preclinical Evaluation as Positive Markers of Tumor Hypoxia
  • Copper-64-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for the Prevention of Tumor Growth at Wound Sites following Laparoscopic Surgery: Monitoring Therapy Response with microPET and Magnetic Resonance Imaging
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