Journal of Nuclear Medicine: 66 (4)

April 1, 2025; Volume 66,Issue 4

Discussions with Leaders

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New Approaches in Radiopharmaceutical Development
John Babich and Lale Kostakoglu

Journal of Nuclear Medicine April 1, 2025, 66 (4) 487-489; DOI: https://doi.org/10.2967/jnumed.125.269492

The State of the Art

Open Access
Theranostics for Neuroblastoma: Making Molecular Radiotherapy Work Better
Peter J. Gawne, Helen E. Bryant, Steven G. DuBois, Sally L. George, Juliet Gray, Leona Knox, Kyle B. Matchett, Connie Peet, Katherine A. Vallis, Hugh J. Wallace, Simon Wan and Mark N. Gaze

Journal of Nuclear Medicine April 1, 2025, 66 (4) 490-496; DOI: https://doi.org/10.2967/jnumed.124.269121

Is It Really Happening?

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Are FAP Theranostics Really Happening? Will Radiochemistry or Biology Win?
Rodney J. Hicks

Journal of Nuclear Medicine April 1, 2025, 66 (4) 497-499; DOI: https://doi.org/10.2967/jnumed.124.267547

Hot Topics

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From Stabilization to Depletion: Molecular Imaging to Measure Therapeutic Response in ATTR-CA
Shilpa Vijayakumar and Sharmila Dorbala

Journal of Nuclear Medicine April 1, 2025, 66 (4) 500-501; DOI: https://doi.org/10.2967/jnumed.124.268035

Focus on Molecular Imaging

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Molecular Imaging of Pulmonary Fibrosis
Margaret B. Allison, Ciprian Catana, Iris Y. Zhou, Peter Caravan and Sydney B. Montesi

Journal of Nuclear Medicine April 1, 2025, 66 (4) 502-505; DOI: https://doi.org/10.2967/jnumed.124.267852

Special Contribution

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Self-Citation Among Highly Cited Nuclear Medicine and Medical Imaging Researchers
Malik E. Juweid, Obada Al-leimon, Soud F. Al-Qasem, Ibrahim Aljarah and Yaser Rayyan

Journal of Nuclear Medicine April 1, 2025, 66 (4) 506-508; DOI: https://doi.org/10.2967/jnumed.124.269357
Open Access
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories
Tahir Yusufaly, Emilie Roncali, Julia Brosch-Lenz, Carlos Uribe, Abhinav K. Jha, Geoffrey Currie, Joyita Dutta, Georges El-Fakhri, Helena McMeekin, Neeta Pandit-Taskar, Jazmin Schwartz, Kuangyu Shi, Lidia Strigari, Habib Zaidi, Babak Saboury and Arman Rahmim

Journal of Nuclear Medicine April 1, 2025, 66 (4) 509-515; DOI: https://doi.org/10.2967/jnumed.124.267927

Oncology

Clinical
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  Prognostic Value of FDG PET Metabolic Parameters Before and After 42 Gy of Radiochemotherapy in Patients with Inoperable Stage III Nonsmall Cell Lung Cancer
  Pierre Vera, Philippe Giraud, Sébastien Hapdey, Pierrick Gouel, Orianne Jan, Paul Le Roux, Alexandra Langlais, Emilie Lévêque, Florence Le Tinier, Anaïs Olivier, Etienne Martin, Alina Berriolo-Riedinger, Nicolas Pourel, Jean Marc Broglia, Pierre Boisselier, Sophie Guillemard, Naji Salem, Isabelle Brenot-Rossi, Camilo Garcia, Céline Berthold, Etienne Giroux-Leprieur, Damien Moreau, Sophie Guillerm, Khadija Benali, Laurent Tessonnier, Clarisse Audigier-Valette, Delphine Lerouge, Elske Quak, Carole Massabeau, Frédéric Courbon, Maxime Loo, Anne Larrouy, Nadia Ghazzar, Philippe Chaumet-Riffaud, Elodie Amour, Gérard Zalcman, Romain Modzelewski and Sébastien Thureau
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 516-524; DOI: https://doi.org/10.2967/jnumed.124.268499
- FEATURED CLINICAL INVESTIGATION ARTICLE
  - Open Access
    Impact of Radioactive Iodine Treatment on Long-Term Relative Survival in Patients with Papillary and Follicular Thyroid Cancer: A SEER-Based Study Covering Histologic Subtypes and Recurrence Risk Categories
    Henning Weis, Jasmin Weindler, Katharina Schmidt, Martin Hellmich, Alexander Drzezga and Matthias Schmidt
    
    Journal of Nuclear Medicine April 1, 2025, 66 (4) 525-530; DOI: https://doi.org/10.2967/jnumed.124.269091
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  PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study
  Cristian Udovicich, Mathias Bressel, Jamil Manji, Muhammad Ali, Lewis Au, Arun A. Azad, James P. Buteau, Sarat Chander, David Chang, Renu Eapen, Nathan Lawrentschuk, Sidney M. Levy, Daniel Moon, Declan G. Murphy, Marlon Perera, Mark Shaw, Lavinia Spain, Ben Tran, Michael S. Hofman and Shankar Siva
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 531-536; DOI: https://doi.org/10.2967/jnumed.124.268639
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  [¹⁸F]-FDG PET/CT in the Initial Staging of Squamous Cell Cancer of the Anal Canal: Results of a Prospective Multicenter Registry
  Ur Metser, Jelena Lukovic, Aruz Mesci, Pamela MacCrostie, Rosanna Chan, Victor Mak, Lisa Avery, Amit Singnurkar, Deanna L. Langer, Kara Ly and Andres Kohan
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 537-542; DOI: https://doi.org/10.2967/jnumed.124.269289
Translational
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  [^99mTc]Tc-MY6349 Probe for Trop2-Targeted SPECT Imaging: From Preclinical to Pilot Clinical Study
  Yining Sun, Zhixin Hao, Hannan Gao, Guangjie Yang, Bo Pan, Min Zhu, Yakun Wan, Jiyun Shi, Li Huo, Haojun Chen and Fan Wang
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 543-551; DOI: https://doi.org/10.2967/jnumed.124.268564
Basic
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  Development and Preclinical Evaluation of [⁶⁴Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics
  Xiaoyan Li, You Zhang, Jason C. Mixdorf, Qianyun Wu, Sophia J. Lee, Jonathan W. Engle, Todd E. Barnhart, Shannon C. Kenney, Lixin Rui, Weijun Wei and Weibo Cai
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 552-558; DOI: https://doi.org/10.2967/jnumed.124.268835
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  PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti–PD-L1 Immunotherapy and Targeted Therapy
  Céline Chevaleyre, Léa Zimmermann, Simon Specklin, Dimitri Kereselidze, Alizée Bouleau, Steven Dubois, Hélène Quelquejay, Bernard Maillère, Nicolas Tournier, Hervé Nozach and Charles Truillet
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 559-564; DOI: https://doi.org/10.2967/jnumed.124.268586

Theranostics

Clinical
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  Full-Body Tumor Response Heterogeneity of Metastatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radiopharmaceutical Therapy
  Victor Santoro-Fernandes, Brayden Schott, Amy J. Weisman, Ojaswita Lokre, Steve Y. Cho, Scott B. Perlman, Timothy G. Perk and Robert Jeraj
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 565-571; DOI: https://doi.org/10.2967/jnumed.124.267809
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  Clinical Trial Protocol for LuCAB: A Phase I–II Trial Evaluating Cabazitaxel in Combination with [¹⁷⁷Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer
  Louise Kostos, James P. Buteau, Grace Kong, Ben Tran, Mohammad B. Haskali, Michael Fahey, Megan Crumbaker, Louise Emmett, Michael S. Hofman and Arun A. Azad
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 572-578; DOI: https://doi.org/10.2967/jnumed.124.269252
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  Therapy-Related Myeloid Neoplasms After [¹⁷⁷Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series
  Michal Eifer, Duncan E.K. Sutherland, Isaac Goncalves, James P. Buteau, Lewis Au, Arun A. Azad, Louise Emmett, Grace Kong, Louise Kostos, Aravind S. Ravi Kumar, Edmond M. Kwan, Elizabeth Medhurst, Shahneen Sandhu, Ben Tran, Alexander W. Wyatt and Michael S. Hofman
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 579-584; DOI: https://doi.org/10.2967/jnumed.124.268640
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  Comparison of [⁶⁸Ga]Ga-Fibroblast Activation Protein Inhibitor–04 and [¹⁸F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy
  Rongxi Wang, Jiarou Wang, Jialin Xiang, Huimin Sui, Linlin Li, Chenhao Jia, Xingtong Peng, Xiaoyuan Chen, Zhaohui Zhu and Jingjing Zhang
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 585-591; DOI: https://doi.org/10.2967/jnumed.124.268258
Basic
- Open Access
  ²²⁵Ac/⁸⁹Zr-Labeled N4MU01 Radioimmunoconjugates as Theranostics Against Nectin-4–Positive Triple-Negative Breast Cancer
  Hanan Babeker, Fabrice Ngoh Njotu, Jessica Pougoue Ketchemen, Alissar Monzer, Anjong Florence Tikum, Alireza Doroudi, Emmanuel Nwangele, Maruti Uppalapati and Humphrey Fonge
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 592-598; DOI: https://doi.org/10.2967/jnumed.124.268387
- Open Access
  Preclinical Evaluation of ¹⁷⁷Lu-rhPSMA-10.1, a Radiopharmaceutical for Prostate Cancer: Biodistribution and Therapeutic Efficacy
  Caroline Foxton, Bradley Waldron, Rikke Veggerby Grønlund, Jaime (Jim) Simón, Bart Cornelissen, Edward O’Neill and Daniel Stevens
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 599-604; DOI: https://doi.org/10.2967/jnumed.124.268508
- FEATURED ARTICLE OF THE MONTH
  - You have access
    IL13Rα2-Targeting Antibodies for Immuno-PET in Solid Malignancies
    Leah Gajecki, Irina V. Lebedeva, Yu-Rou Liao, Daisy Ambriz, Lukas M. Carter, Melina Kumpf, Samantha Lovibond, Justin S. Hachey, Maya S. Graham, Michael Postow, Jason S. Lewis, David P. Andrew, Manuel Baca, Heiko Schöder, Steven M. Larson, Darren R. Veach and Simone Krebs
    
    Journal of Nuclear Medicine April 1, 2025, 66 (4) 605-611; DOI: https://doi.org/10.2967/jnumed.124.268762

Neurology

Clinical
- Open Access
  Development and Validation of a ¹⁸F-Flortaucipir PET Visual Stratification Method
  Ilke Tunali, Jian Wang, Anupa K. Arora, Min Jung Kim, Sergey Shcherbinin, Michael Pontecorvo and Leonardo Iaccarino
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 612-619; DOI: https://doi.org/10.2967/jnumed.124.268700
- Open Access
  Imaging Synaptic Density in Aging and Alzheimer Disease with [¹⁸F]SynVesT-1
  Joseph Giorgio, David N. Soleimani-Meigooni, Mustafa Janabi, Suzanne L. Baker, Xi Chen, Tyler N. Toueg, Robby Weimer, Bastian Zinnhardt, Ari Green, Gil D. Rabinovici and William J. Jagust
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 620-625; DOI: https://doi.org/10.2967/jnumed.124.269005

Cardiovascular

Clinical
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  Biodistribution, Safety Profile, and Radiation Dosimetry of [¹⁸F]SYN2, a PET Cardiac Perfusion Tracer, in Healthy Subjects
  Juhani Knuuti, Małgorzata Kobylecka, Seweryn Krajewski, Lukasz Steczek, Karina Gotowicz, Joanna Towpik, Kari Kalliokoski, Tuula Tolvanen, Magdalena Kostkiewicz, Przemysław Kozanecki, Joanna Włostowska, Mirosław Dziuk, Leszek Królicki, Jacek Bil, Piotr J. Slomka, Timothy M. Bateman, Mouaz H. Al-Mallah, Panithaya Chareonthaitawee, Prem Soman and Cezary Kozanecki
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 626-633; DOI: https://doi.org/10.2967/jnumed.124.268872

Inflammation/Infection

Clinical
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  Differences in Fibroinflammatory Activity Shown on ⁶⁸Ga-FAPI-04 and ¹⁸F-FDG PET/CT in the Two Subtypes of IgG4-Related Disease
  Silu Liu, Qingqing Pan, Hongzhe Zhang, Linyi Peng, Wen Zhang, YunLu Feng, Dong Wu and Yaping Luo
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 634-640; DOI: https://doi.org/10.2967/jnumed.124.268943

Radiobiology/Dosimetry

Clinical
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  Tumor Dose–Response Relationship of [¹³¹I]MIBG Therapy in Patients with Neural Crest Tumors by Means of [¹²⁴I]MIBG PET
  Alexandros Moraitis, Andre Prochnow, Thorsten Dirk Poeppel, Jochen Schmitz, Christina Laschinsky, Ken Herrmann, Andreas Bockisch, Pedro Fragoso Costa, David Kersting and Walter Jentzen
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 641-647; DOI: https://doi.org/10.2967/jnumed.124.269377

AI/Advanced Image Analysis

Clinical
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  Artificial Intelligence–Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging
  Robert J.H. Miller, Paul Kavanagh, Mark Lemley, Joanna X. Liang, Tali Sharir, Andrew J. Einstein, Mathews B. Fish, Terrence D. Ruddy, Philipp A. Kaufmann, Albert J. Sinusas, Edward J. Miller, Timothy M. Bateman, Sharmila Dorbala, Marcelo Di Carli, Sean Hayes, John Friedman, Daniel S. Berman, Damini Dey and Piotr J. Slomka
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 648-653; DOI: https://doi.org/10.2967/jnumed.124.268079

Physics and Instrumentation

Clinical
- Open Access
  Total-Body Parametric Imaging Using Relative Patlak Plot
  Siqi Li, Yasser G. Abdelhafez, Lorenzo Nardo, Simon R. Cherry, Ramsey D. Badawi and Guobao Wang
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 654-661; DOI: https://doi.org/10.2967/jnumed.124.268496

The Illustrated Post

Clinical
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  CCK₂ Receptor Ligand [⁶⁸Ga]Ga-DOTA-CCK-66 PET/CT Outperforms [⁶⁸Ga]Ga-DOTATOC PET/CT in a Patient with Small Cell Lung Cancer
  Oliver Viering, Nadine Holzleitner, Rainer Claus, Adriana Amerein, Niklas Dreher, Johanna S. Enke, Alexander Dierks, Christian H. Pfob, Malte Kircher, Veronika Felber, Thomas Günther and Constantin Lapa
  
  Journal of Nuclear Medicine April 1, 2025, 66 (4) 662; DOI: https://doi.org/10.2967/jnumed.124.269201

Letters to the Editor

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¹⁷⁶Lu Radiation Dose of Long–Axial Field of View PET Scanners
Samaneh Mostafapour, Joyce van Sluis, Adriaan A. Lammertsma and Charalampos Tsoumpas

Journal of Nuclear Medicine April 1, 2025, 66 (4) 663; DOI: https://doi.org/10.2967/jnumed.124.269187
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The PRIMARY Score: Present and Future
Linlin Guo and Guohua Shen

Journal of Nuclear Medicine April 1, 2025, 66 (4) 663-664; DOI: https://doi.org/10.2967/jnumed.124.267898

Department

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Erratum
Journal of Nuclear Medicine April 1, 2025, 66 (4) 664;

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Table of Contents

Discussions with Leaders

The State of the Art

Is It Really Happening?

Hot Topics

Focus on Molecular Imaging

Special Contribution

Oncology

Clinical

FEATURED CLINICAL INVESTIGATION ARTICLE

Translational

Basic

Theranostics

Clinical

Basic

FEATURED ARTICLE OF THE MONTH

Neurology

Clinical

Cardiovascular

Clinical

Inflammation/Infection

Clinical

Radiobiology/Dosimetry

Clinical

AI/Advanced Image Analysis

Clinical

Physics and Instrumentation

Clinical

The Illustrated Post

Clinical

Letters to the Editor

Department

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