Journal of Nuclear Medicine: 66 (3)

March 1, 2025; Volume 66,Issue 3

Editor’s Page

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Reflections on the Demand for PSMA- and SSTR-Targeted Radiopharmaceutical Therapies: Why We Were Wrong (and Why We Will Be Right Eventually)
Johannes Czernin, Lisa Bodei, Irvin Modlin and Jeremie Calais

Journal of Nuclear Medicine March 1, 2025, 66 (3) 333-336; DOI: https://doi.org/10.2967/jnumed.124.269401

Discussions with Leaders

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Advancing Tomorrow’s Cancer Medicines
Jacob S. Van Naarden, Ken Herrmann and Johannes Czernin

Journal of Nuclear Medicine March 1, 2025, 66 (3) 337-339; DOI: https://doi.org/10.2967/jnumed.124.269354

The State of the Art

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Green Nuclear Medicine and Radiotheranostics
Patrick Veit-Haibach, Ken Herrmann, Richard Zimmermann and Roland Hustinx

Journal of Nuclear Medicine March 1, 2025, 66 (3) 340-343; DOI: https://doi.org/10.2967/jnumed.124.268928

Focus on Molecular Imaging

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Molecular Imaging in Cancer Chemoresistance: What’s Brewing?
Luca Urso, Licia Uccelli, Alessandra Boschi, Orazio Schillaci and Luca Filippi

Journal of Nuclear Medicine March 1, 2025, 66 (3) 344-348; DOI: https://doi.org/10.2967/jnumed.124.268967

Is It Really Happening?

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SPECT Deserves RESPECT: The Potential of SPECT/CT to Optimize Patient Outcomes with Theranostics Therapy
Louise Emmett

Journal of Nuclear Medicine March 1, 2025, 66 (3) 349-350; DOI: https://doi.org/10.2967/jnumed.124.268325

Editorial

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China’s Innovations in Nuclear Medicine: Global Insights into Clinical Advancements and Impact
Xun Wang, Yifan Dong and Shuo Zhang

Journal of Nuclear Medicine March 1, 2025, 66 (3) 351; DOI: https://doi.org/10.2967/jnumed.124.269185

Theranostics

Clinical
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  Evaluation of Surgical Margins with Intraoperative PSMA PET/CT and Their Prognostic Value in Radical Prostatectomy
  Alexandros Moraitis, Theresa Kahl, Jens Kandziora, Walter Jentzen, David Kersting, Lukas Püllen, Henning Reis, Jens Köllermann, Claudia Kesch, Ulrich Krafft, Boris A. Hadaschik, Habib Zaidi, Ken Herrmann, Francesco Barbato, Wolfgang P. Fendler, Christopher Darr and Pedro Fragoso Costa
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 352-358; DOI: https://doi.org/10.2967/jnumed.124.268719
- Open Access
  Safety, Dosimetry, and Feasibility of [⁶⁸Ga]Ga-PSMA-R2 as an Imaging Agent in Patients with Biochemical Recurrence or Metastatic Prostate Cancer
  Liza Lindenberg, Thomas A. Hope, Frank I. Lin, Steven P. Rowe, Darko Pucar, Noella Gilbert, Daniela Chicco, Beilei He, Benedikt Feuerecker, Elena Castaldi and Lilja B. Solnes
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 359-365; DOI: https://doi.org/10.2967/jnumed.124.268318
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  ^99mTc-MIP-1404 SPECT/CT Companion Diagnostic for ¹⁷⁷Lu-PSMA Therapy in Metastatic Castration-Resistant Prostate Cancer
  Thorsten Derlin, Liam Widjaja, Nina Natascha Harke, Christoph Czerner, Desiree Weiberg, Tobias L. Ross and Frank M. Bengel
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 366-372; DOI: https://doi.org/10.2967/jnumed.124.269319
- BRIEF COMMUNICATION
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    Exploring the Flare Phenomenon in Patients with Castration-Resistant Prostate Cancer: Enzalutamide-Induced PSMA Upregulation Observed on PSMA PET
    Suzanne van der Gaag, André N. Vis, Imke H. Bartelink, Josephina C.C. Koppes, Marina Hodolic, Harry Hendrikse and Daniela E. Oprea-Lager
    
    Journal of Nuclear Medicine March 1, 2025, 66 (3) 373-376; DOI: https://doi.org/10.2967/jnumed.124.268340
Translational
- Open Access
  ¹⁷⁷Lu-Labeled Anticlaudin 6 Monoclonal Antibody for Targeted Therapy in Esophageal Cancer
  Huan Du, Xiaofei Hao, Binwei Lin, Mingming Tang, Decai Wang, Xia Yang, Jing Wang, Liling Qin, Yuchuan Yang and Xiaobo Du
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 377-384; DOI: https://doi.org/10.2967/jnumed.124.268487
Basic
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  DNA-Dependent Protein Kinase Inhibitor Peposertib Enhances Efficacy of ¹⁷⁷Lu-Based Radioimmunotherapy in Preclinical Models of Prostate and Renal Cell Carcinoma
  Cameron N. Johnstone, Laura D. Osellame, Zhipeng Cao, Alexander F. McDonald, Angela Rigopoulos, Ingrid J.G. Burvenich, Christian W. Wichmann, Nancy Guo, Alesia N. Ivashkevich, Michael P. Wheatcroft, Edwin B. Yan, Astrid Zimmermann, Frank T. Zenke, Christian Sirrenberg, Fiona E. Scott and Andrew M. Scott
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 385-390; DOI: https://doi.org/10.2967/jnumed.124.268695
- Open Access
  Side-by-Side Comparison of the In Vivo Performance of [²¹²Pb]Pb-DOTAMTATE and Other SSTR2-Targeting Compounds
  Amal Saidi, Tania A. Stallons, Amy G. Wong, Aaron T. Schatzmann, Ugur Soysal and Julien J. Torgue
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 391-397; DOI: https://doi.org/10.2967/jnumed.124.268345

Neurology

Clinical
- FEATURED CLINICAL INVESTIGATION ARTICLE
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    PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation
    Xuefeng Yan, Martin Noergaard, Cheryl L. Morse, Jeih-San Liow, Jinsoo Hong, Douglas Greve, Sanjay Telu, Min-Jeong Kim, Jose A. Montero Santamaria, Anthony Galassi, Ningping Feng, Sarah K. Williams Avram, Ted B. Usdin, Shawn Wu, Andrea Zhang, Lester S. Manly, Madeline Jenkins, Maia Van Buskirk, Adrian Lee, Sami S. Zoghbi, Victor W. Pike, Paolo Zanotti-Fregonara and Robert B. Innis
    
    Journal of Nuclear Medicine March 1, 2025, 66 (3) 398-404; DOI: https://doi.org/10.2967/jnumed.124.268525
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  Dopaminergic Mechanisms of Cognitive Flexibility: An [¹⁸F]Fallypride PET Study
  Isabelle Miederer, Hans-Georg Buchholz, Lena Rademacher, Cindy Eckart, Dominik Kraft, Markus Piel, Christian J. Fiebach and Mathias Schreckenberger
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 405-409; DOI: https://doi.org/10.2967/jnumed.124.268317
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  [¹⁸F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [¹⁵O]Water
  Jessie Fanglu Fu, Meher R. Juttukonda, Arun Garimella, Andrew N. Salvatore, Cristina Lois, Anthony Ranasinghe, Nikos Efthimiou, Hasan Sari, William Aye, Nicolas J. Guehl, Georges El Fakhri, Keith A. Johnson, Bradford C. Dickerson, David Izquierdo-Garcia, Ciprian Catana and Julie C. Price
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 410-417; DOI: https://doi.org/10.2967/jnumed.124.268701

Inflammation/Infection

Clinical
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  ⁶⁸Ga-FAPI-04 PET/CT Imaging for Assessing Renal Tubulointerstitial Fibrosis in Lupus Nephritis
  Shuyi Yu, Zhixia Yang, Zetao Ding, Yingqi Jia, Liyan Wan, Lei Li, Jing Lv, Haoyu Pan, Jinyi Qian, Xiaohan Wei, Yue Yang, Yunlong Zan, Jialin Teng, Biao Li, Chengde Yang, Jing Xu, Luan Xue, Hui Shi and Min Zhang
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 418-424; DOI: https://doi.org/10.2967/jnumed.124.268643
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  Collagen Hybridizing Peptide–Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis
  Azmi A. Ahmad, Mean Ghim, Gunjan Kukreja, Afarin Neishabouri, Zhengxing Zhang, Jie Li, Mani Salarian, Jakub Toczek, Kiran Gona, Keshvad Hedayatyanfard, Tian Morrison, Jiasheng Zhang, Yiyun Henry Huang, Chi Liu, S. Michael Yu and Mehran M. Sadeghi
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 425-433; DOI: https://doi.org/10.2967/jnumed.124.268832

Endocrinology

Clinical
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  A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[¹⁸F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism
  Daniel Gillett, Russell Senanayake, James MacFarlane, Waiel Bashari, August Palma, Lihua Hu, Ines Harper, Iosif A. Mendichovszky, Gunnar Antoni, Per Hellman, Anders Sundin, Matthew Hird, István Boros, Morris J. Brown, Heok Cheow, Luigi Aloj, Franklin Aigbirhio and Mark Gurnell
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 434-440; DOI: https://doi.org/10.2967/jnumed.124.268425

Radiobiology/Dosimetry

Clinical
- Open Access
  An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 4: Impact of Fitting Functions in Estimated Absorbed Doses
  Sara Kurkowska, Julia Brosch-Lenz, Yuni K. Dewaraja, Eric Frey, John Sunderland and Carlos Uribe
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 441-448; DOI: https://doi.org/10.2967/jnumed.124.268612
- Open Access
  Dosimetry of [¹⁷⁷Lu]Lu-DOTATATE in Patients with Advanced Midgut Neuroendocrine Tumors: Results from a Substudy of the Phase III NETTER-1 Trial
  Lisa Bodei, Marta Cremonesi, Mahila Ferrari, Erik S. Mittra, Harshad R. Kulkarni, Christophe M. Deroose, Rajaventhan Srirajaskanthan, John Ramage, Chiara Maria Grana, Francesca Botta, Matthias M. Weber, Matthias Miederer, Ryan Reddy, Daniela Chicco, Maurizio F. Mariani, Arnaud Demange, Jack L. Erion, Germo Gericke and Eric Krenning
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 449-456; DOI: https://doi.org/10.2967/jnumed.124.268903
- SPECIAL CONTRIBUTION
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    MIRD Pamphlet No. 32: A MIRD Recovery Coefficient Model for Resolution Characterization and Shape-Specific Partial-Volume Correction
    Harry Marquis, C. Ross Schmidtlein, Robin de Nijs, Pablo Mínguez Gabiña, Johan Gustafsson, Gunjan Kayal, Juan C. Ocampo Ramos, Lukas M. Carter, Dale L. Bailey and Adam L. Kesner
    
    Journal of Nuclear Medicine March 1, 2025, 66 (3) 457-465; DOI: https://doi.org/10.2967/jnumed.124.268520

AI/Advanced Image Analysis

Clinical
- Open Access
  Positron Range Correction Helps Enhance the Image Quality of Cardiac ⁸²Rb PET/CT
  Martin Lyngby Lassen, Hunor Kertész, Ivo Rausch, Vladimir Panin, Maurizio Conti, Sven Zuehlsdorff, Jorge Cabello, Deepak Bharkhada, Robert DeKemp, Andreas Kjaer, Thomas Beyer and Philip Hasbak
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 466-472; DOI: https://doi.org/10.2967/jnumed.124.267855

Molecular Imaging

Translational
- FEATURED ARTICLE OF THE MONTH
  - You have access
    Pilot Study of Nectin-4–Targeted PET Imaging Agent ⁶⁸Ga-FZ-NR-1 in Triple-Negative Breast Cancer from Bench to First-in-Human
    Li Sun, Yuyun Sun, Ke Zuo, Lei Fan, Xiao Wang, Jianping Zhang, Silong Hu, Xiaosheng Liu, Jindian Li, Ye Li, Zhiming Shao, Xiaoping Xu, Aiguo Wu and Shaoli Song
    
    Journal of Nuclear Medicine March 1, 2025, 66 (3) 473-479; DOI: https://doi.org/10.2967/jnumed.124.269024

Practice Standards

Clinical
- Open Access
  Summary: EANM/SNMMI Release Joint Guideline/Procedure Standard for [¹⁸F]FDG Hybrid PET Use in Infection and Inflammation in Adults, Version 2.0
  Olivier Gheysens, Matthieu Pelletier-Galarneau, Giorgio Treglia, Ora Israel, Francois Jamar and Gad Abikhzer
  
  Journal of Nuclear Medicine March 1, 2025, 66 (3) 480-481; DOI: https://doi.org/10.2967/jnumed.125.269538

The Illustrated Post

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CD38-Targeted ⁸⁹Zr-DFO-Daratumumab PET of Myeloma: Immuno-PET Impacting Clinical Care
Gary A. Ulaner, Jason Lewis and Ola Landgren

Journal of Nuclear Medicine March 1, 2025, 66 (3) 482; DOI: https://doi.org/10.2967/jnumed.124.269393

Letters to the Editor

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On Facilitating the End of the Linear No-Threshold Era
Eduardo Galiano

Journal of Nuclear Medicine March 1, 2025, 66 (3) 483; DOI: https://doi.org/10.2967/jnumed.124.269042
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Reply: On Facilitating the End of the Linear No-Threshold Era
Mohan Doss

Journal of Nuclear Medicine March 1, 2025, 66 (3) 483-484; DOI: https://doi.org/10.2967/jnumed.124.269292
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A Comment on “Effectiveness and Patient Experiences of Rhenium Skin Cancer Therapy for Nonmelanoma Skin Cancer: Interim Results from the EPIC-Skin Study”
Miranda Wallace and Jim Muir

Journal of Nuclear Medicine March 1, 2025, 66 (3) 484-485; DOI: https://doi.org/10.2967/jnumed.124.269058
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Reply: A Comment on “Effectiveness and Patient Experiences of Rhenium Skin Cancer Therapy for Nonmelanoma Skin Cancer: Interim Results from the EPIC-Skin Study”
Gerhard Dahlhoff

Journal of Nuclear Medicine March 1, 2025, 66 (3) 485; DOI: https://doi.org/10.2967/jnumed.124.269115

In Memoriam

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Kenneth A. Krohn, PhD, 1945–2024
Janet Eary, Jeanne Link, David Mankoff, David Vera and Tom Ruth

Journal of Nuclear Medicine March 1, 2025, 66 (3) 486; DOI: https://doi.org/10.2967/jnumed.124.269449

Department

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Erratum
Journal of Nuclear Medicine March 1, 2025, 66 (3) 481;

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Table of Contents

Editor’s Page

Discussions with Leaders

The State of the Art

Focus on Molecular Imaging

Is It Really Happening?

Editorial

Theranostics

Clinical

BRIEF COMMUNICATION

Translational

Basic

Neurology

Clinical

FEATURED CLINICAL INVESTIGATION ARTICLE

Inflammation/Infection

Clinical

Endocrinology

Clinical

Radiobiology/Dosimetry

Clinical

SPECIAL CONTRIBUTION

AI/Advanced Image Analysis

Clinical

Molecular Imaging

Translational

FEATURED ARTICLE OF THE MONTH

Practice Standards

Clinical

The Illustrated Post

Letters to the Editor

In Memoriam

Department

In this issue

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