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Research ArticleBasic Science Investigation

A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake

Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri and Samuele Cazzamalli
Journal of Nuclear Medicine December 2022, 63 (12) 1852-1858; DOI: https://doi.org/10.2967/jnumed.122.264036
Andrea Galbiati
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
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Aureliano Zana
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
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Matilde Bocci
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
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Jacopo Millul
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
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Abdullah Elsayed
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
2Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland; and
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Jacqueline Mock
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
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Dario Neri
2Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland; and
3Philogen S.p.A., Siena, Italy
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Samuele Cazzamalli
1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
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Article Information

vol. 63 no. 12 1852-1858
DOI 
https://doi.org/10.2967/jnumed.122.264036
PubMed 
35589404

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 21, 2022
  • Revision received May 10, 2022
  • Published online December 1, 2022.

Article Versions

  • previous version (May 19, 2022 - 13:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Andrea Galbiati*,1,
  2. Aureliano Zana*,1,
  3. Matilde Bocci1,
  4. Jacopo Millul1,
  5. Abdullah Elsayed1,2,
  6. Jacqueline Mock1,
  7. Dario Neri2,3 and
  8. Samuele Cazzamalli1
  1. 1Research and Development Department, Philochem AG, Otelfingen, Switzerland;
  2. 2Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland; and
  3. 3Philogen S.p.A., Siena, Italy
  1. For correspondence or reprints, contact Samuele Cazzamalli (samuele.cazzamalli{at}philochem.ch) or Dario Neri (neri{at}pharma.ethz.ch).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (12)
Journal of Nuclear Medicine
Vol. 63, Issue 12
December 1, 2022
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A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake
Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Samuele Cazzamalli
Journal of Nuclear Medicine Dec 2022, 63 (12) 1852-1858; DOI: 10.2967/jnumed.122.264036

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A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake
Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Samuele Cazzamalli
Journal of Nuclear Medicine Dec 2022, 63 (12) 1852-1858; DOI: 10.2967/jnumed.122.264036
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  • Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics
  • Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy
  • Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy
  • Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions
  • Fibroblast Activation Protein-Targeted Radioligand Therapy for Treatment of Solid Tumors
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Keywords

  • fibroblast activation protein
  • theranostics
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  • targeted radiotherapy
  • dimeric targeting ligands
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