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Research ArticleTheranostics
Open Access

FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients

Frederik L. Giesel, Sebastian Adeberg, Mustafa Syed, Thomas Lindner, Luis David Jiménez-Franco, Eleni Mavriopoulou, Fabian Staudinger, Eric Tonndorf-Martini, Sebastian Regnery, Stefan Rieken, Rami El Shafie, Manuel Röhrich, Paul Flechsig, Andreas Kluge, Annette Altmann, Jürgen Debus, Uwe Haberkorn and Clemens Kratochwil
Journal of Nuclear Medicine February 2021, 62 (2) 201-207; DOI: https://doi.org/10.2967/jnumed.120.245084
Frederik L. Giesel
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Sebastian Adeberg
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
3Heidelberg Ion-Beam Therapy Center, Heidelberg, Germany
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
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Mustafa Syed
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
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Thomas Lindner
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Luis David Jiménez-Franco
6ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft mbH, Dresden, Germany
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Eleni Mavriopoulou
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Fabian Staudinger
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Eric Tonndorf-Martini
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
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Sebastian Regnery
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
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Stefan Rieken
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
7Department of Radiation Oncology, University Hospital Göttingen, Göttingen, Germany; and
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Rami El Shafie
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
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Manuel Röhrich
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Paul Flechsig
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Andreas Kluge
6ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft mbH, Dresden, Germany
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Annette Altmann
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Jürgen Debus
2Heidelberg Institute of Radiation Oncology, Heidelberg, Germany
3Heidelberg Ion-Beam Therapy Center, Heidelberg, Germany
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
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Uwe Haberkorn
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
8Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
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Clemens Kratochwil
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Journal of Nuclear Medicine: 62 (2)
Journal of Nuclear Medicine
Vol. 62, Issue 2
February 1, 2021
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FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients
Frederik L. Giesel, Sebastian Adeberg, Mustafa Syed, Thomas Lindner, Luis David Jiménez-Franco, Eleni Mavriopoulou, Fabian Staudinger, Eric Tonndorf-Martini, Sebastian Regnery, Stefan Rieken, Rami El Shafie, Manuel Röhrich, Paul Flechsig, Andreas Kluge, Annette Altmann, Jürgen Debus, Uwe Haberkorn, Clemens Kratochwil
Journal of Nuclear Medicine Feb 2021, 62 (2) 201-207; DOI: 10.2967/jnumed.120.245084

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FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients
Frederik L. Giesel, Sebastian Adeberg, Mustafa Syed, Thomas Lindner, Luis David Jiménez-Franco, Eleni Mavriopoulou, Fabian Staudinger, Eric Tonndorf-Martini, Sebastian Regnery, Stefan Rieken, Rami El Shafie, Manuel Röhrich, Paul Flechsig, Andreas Kluge, Annette Altmann, Jürgen Debus, Uwe Haberkorn, Clemens Kratochwil
Journal of Nuclear Medicine Feb 2021, 62 (2) 201-207; DOI: 10.2967/jnumed.120.245084
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Keywords

  • FAPI PET/CT
  • cancer-associated fibroblasts
  • lung cancer
  • radiation dosimetry
  • cold kit
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