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Journal of Nuclear Medicine

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Table of Contents

February 1, 2021; Volume 62,Issue 2

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 10A;

Editor's Page

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    The Solutions Come from Science and Knowledge
    Johannes Czernin and Caius Radu
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 145; DOI: https://doi.org/10.2967/jnumed.120.261792

Discussions with Leaders

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    Oliver Sartor Talks with Thomas A. Hope, Jeremie Calais, and Wolfgang P. Fendler About FDA Approval of PSMA
    Oliver Sartor, Thomas A. Hope, Jeremie Calais and Wolfgang P. Fendler
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 146-148; DOI: https://doi.org/10.2967/jnumed.120.261834

The State of the Art

  • Open Access
    68Ga-PSMA-11 NDA Approval: A Novel and Successful Academic Partnership
    Giuseppe Carlucci, Robin Ippisch, Roger Slavik, Ashley Mishoe, Joseph Blecha and Shaojun Zhu
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 149-155; DOI: https://doi.org/10.2967/jnumed.120.260455

Editorial

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    Real-World Data as an Evidence Source in Nuclear Medicine
    Ariel B. Bourla and Ken Herrmann
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 156-157; DOI: https://doi.org/10.2967/jnumed.120.258665

Hot Topics

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    11C Dosimetry Scans Should Be Abandoned
    Paolo Zanotti-Fregonara, Adriaan A. Lammertsma and Robert B. Innis
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 158-159; DOI: https://doi.org/10.2967/jnumed.120.257402

Focus on Molecular Imaging

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    The Latest Developments in Imaging of Fibroblast Activation Protein
    Annette Altmann, Uwe Haberkorn and Jens Siveke
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 160-167; DOI: https://doi.org/10.2967/jnumed.120.244806

Continuing Education

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    Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications
    Piotr J. Slomka, Jonathan B. Moody, Robert J. H. Miller, Jennifer M. Renaud, Edward P. Ficaro and Ernest V. Garcia
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 168-176; DOI: https://doi.org/10.2967/jnumed.120.242537

Oncology

  • Clinical

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      Assessment of Bone Lesions with 18F-FDG PET Compared with 99mTc Bone Scintigraphy Leads to Clinically Relevant Differences in Metastatic Breast Cancer Management
      Suzanne C. van Es, Ton Velleman, Sjoerd G. Elias, Frederike Bensch, Adrienne H. Brouwers, Andor W.J.M. Glaudemans, Thomas C. Kwee, Marleen Woltman-van Iersel, John H. Maduro, Sjoukje F. Oosting, Elisabeth G.E. de Vries and Carolina P. Schröder
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 177-183; DOI: https://doi.org/10.2967/jnumed.120.244640
    • FEATURED ARTICLE OF THE MONTH

      • <sup>18</sup>F-Fluoroestradiol PET Imaging in a Phase II Trial of Vorinostat to Restore Endocrine Sensitivity in ER+/HER2− Metastatic Breast Cancer
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        18F-Fluoroestradiol PET Imaging in a Phase II Trial of Vorinostat to Restore Endocrine Sensitivity in ER+/HER2− Metastatic Breast Cancer
        Lanell M. Peterson, Brenda F. Kurland, Fengting Yan, Alena Novakova- Jiresova, Vijayakrishna K. Gadi, Jennifer M. Specht, Julie R. Gralow, Erin K. Schubert, Jeanne M. Link, Kenneth A. Krohn, Janet F. Eary, David A. Mankoff and Hannah M. Linden
        Journal of Nuclear Medicine February 1, 2021, 62 (2) 184-190; DOI: https://doi.org/10.2967/jnumed.120.244459
    • BRIEF COMMUNICATION

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        Volumetric PET Response Assessment Outperforms Conventional Criteria in Patients Receiving High-Dose Pembrolizumab for Malignant Mesothelioma
        Justin Ferdinandus, Francesco Barbato, Michal Chodyla, Wolfgang P. Fendler, Lukas Kessler, Kelsey L. Pomykala, Martin Metzenmacher, Frederik Krefting, Thomas Hager, Lale Umutlu, Ken Herrmann and Daniel C. Christoph
        Journal of Nuclear Medicine February 1, 2021, 62 (2) 191-194; DOI: https://doi.org/10.2967/jnumed.120.245803
  • Basic

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      Predicting Gemcitabine Delivery by 18F-FAC PET in Murine Models of Pancreatic Cancer
      James Russell, Milan Grkovski, Isabella J. O’Donoghue, Teja M. Kalidindi, Nagavarakishore Pillarsetty, Eva M. Burnazi, Amanda Kulick, Amber Bahr, Qing Chang, H. Carl LeKaye, Elisa de Stanchina, Kenneth H. Yu and John L. Humm
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 195-200; DOI: https://doi.org/10.2967/jnumed.120.246926

Theranostics

  • Clinical

    • Open Access
      FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients
      Frederik L. Giesel, Sebastian Adeberg, Mustafa Syed, Thomas Lindner, Luis David Jiménez-Franco, Eleni Mavriopoulou, Fabian Staudinger, Eric Tonndorf-Martini, Sebastian Regnery, Stefan Rieken, Rami El Shafie, Manuel Röhrich, Paul Flechsig, Andreas Kluge, Annette Altmann, Jürgen Debus, Uwe Haberkorn and Clemens Kratochwil
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 201-207; DOI: https://doi.org/10.2967/jnumed.120.245084
    • Open Access
      Diagnostic Accuracy of 18F-PSMA-1007 PET/CT Imaging for Lymph Node Staging of Prostate Carcinoma in Primary and Biochemical Recurrence
      Katharina Sprute, Vasko Kramer, Stefan A. Koerber, Manuel Meneses, Rene Fernandez, Cristian Soza-Ried, Mathias Eiber, Wolfgang A. Weber, Isabel Rauscher, Kambiz Rahbar, Michael Schaefers, Tadashi Watabe, Motohide Uemura, Sadahiro Naka, Norio Nonomura, Jun Hatazawa, Constantin Schwab, Viktoria Schütz, Markus Hohenfellner, Tim Holland-Letz, Juergen Debus, Clemens Kratochwil, Horacio Amaral, Pete L. Choyke, Uwe Haberkorn, Camilo Sandoval and Frederik L. Giesel
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 208-213; DOI: https://doi.org/10.2967/jnumed.120.246363
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      68Ga-PSMA PET/CT for Primary Lymph Node and Distant Metastasis NM Staging of High-Risk Prostate Cancer
      Søren Klingenberg, Mads R. Jochumsen, Benedicte P. Ulhøi, Jacob Fredsøe, Karina D. Sørensen, Michael Borre and Kirsten Bouchelouche
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 214-220; DOI: https://doi.org/10.2967/jnumed.120.245605
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      Intraarterial Peptide Receptor Radionuclide Therapy Using 90Y-DOTATOC for Hepatic Metastases of Neuroendocrine Tumors
      Courtney Lawhn-Heath, Nicholas Fidelman, Bryant Chee, Salma Jivan, Evan Armstrong, Li Zhang, Sheila Lindsay, Emily K. Bergsland and Thomas A. Hope
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 221-227; DOI: https://doi.org/10.2967/jnumed.119.241273
  • Basic

    • BRIEF COMMUNICATION

      • Immune-Checkpoint Blockade Enhances <sup>225</sup>Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
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        Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
        Johannes Czernin, Kyle Current, Christine E. Mona, Lea Nyiranshuti, Firas Hikmat, Caius G. Radu and Katharina Lückerath
        Journal of Nuclear Medicine February 1, 2021, 62 (2) 228-231; DOI: https://doi.org/10.2967/jnumed.120.246041
    • Preclinical Characterization of the Radioimmunoconjugate <sup>111</sup>In or <sup>90</sup>Y-FF-21101 Against a P-Cadherin–Expressing Tumor in a Mouse Xenograft Model and a Nonhuman Primate
      Open Access
      Preclinical Characterization of the Radioimmunoconjugate 111In or 90Y-FF-21101 Against a P-Cadherin–Expressing Tumor in a Mouse Xenograft Model and a Nonhuman Primate
      Yuichi Funase, Eri Nakamura, Masamichi Kajita, Yasutaka Saito, Shinobu Oshikiri, Michi Kitano, Masahiko Tokura, Akihiro Hino and Tomoya Uehara
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 232-239; DOI: https://doi.org/10.2967/jnumed.120.245837

Neurology

  • Clinical

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      One-Stop Shop: 18F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases
      Jochen Hammes, Gérard N. Bischof, Karl P. Bohn, Özgür Onur, Anja Schneider, Klaus Fliessbach, Merle C Hönig, Frank Jessen, Bernd Neumaier, Alexander Drzezga and Thilo van Eimeren
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 240-246; DOI: https://doi.org/10.2967/jnumed.120.244061
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      Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging
      Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier and Pedro Rosa-Neto
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 247-252; DOI: https://doi.org/10.2967/jnumed.120.245209
  • Basic

    • <sup>18</sup>F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging
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      18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging
      Ryuichi Harada, Yoshimi Hayakawa, Michinori Ezura, Pradith Lerdsirisuk, Yiqing Du, Yoichi Ishikawa, Ren Iwata, Miho Shidahara, Aiko Ishiki, Akio Kikuchi, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai, Shozo Furumoto and Nobuyuki Okamura
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 253-258; DOI: https://doi.org/10.2967/jnumed.120.244400
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      Preclinical Development of 18F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-d-Aspartate Receptors and Its Utility as a Biomarker for Amyotrophic Lateral Sclerosis
      Hazem Ahmed, Rahel Wallimann, Ahmed Haider, Vahid Hosseini, Stefan Gruber, Marvin Robledo, Thi A.N. Nguyen, Adrienne Müller Herde, Irina Iten, Claudia Keller, Viola Vogel, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 259-265; DOI: https://doi.org/10.2967/jnumed.120.246785

Infectious Disease and Inflammation

  • Clinical

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      Fibroblast Activation Protein–Targeted PET/CT with 68Ga-FAPI for Imaging IgG4-Related Disease: Comparison to 18F-FDG PET/CT
      Yaping Luo, Qingqing Pan, Huaxia Yang, Linyi Peng, Wen Zhang and Fang Li
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 266-271; DOI: https://doi.org/10.2967/jnumed.120.244723

Radiobiology/Dosimetry

  • Clinical

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      Dose–Effect Relationships of 166Ho Radioembolization in Colorectal Cancer
      Caren van Roekel, Remco Bastiaannet, Maarten L.J. Smits, Rutger C. Bruijnen, Arthur J.A.T. Braat, Hugo W.A.M. de Jong, Sjoerd G. Elias and Marnix G.E.H. Lam
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 272-279; DOI: https://doi.org/10.2967/jnumed.120.243832

Molecular Imaging

  • Basic

    • Molecular Imaging of Very Late Antigen-4 in Acute Lung Injury
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      Molecular Imaging of Very Late Antigen-4 in Acute Lung Injury
      Joseph Haddad, Joseph D. Latoche, Shubhanchi Nigam, Michael C. Bellavia, Kathryn E. Day, Qin Zhu, W. Barry Edwards, Carolyn J. Anderson and Sina Tavakoli
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 280-286; DOI: https://doi.org/10.2967/jnumed.120.242347

Physics and Instrumentation

  • Clinical

    • Ultra-Fast List-Mode Reconstruction of Short PET Frames and Example Applications
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      Ultra-Fast List-Mode Reconstruction of Short PET Frames and Example Applications
      Matthew G. Spangler-Bickell, Timothy W. Deller, Valentino Bettinardi and Floris Jansen
      Journal of Nuclear Medicine February 1, 2021, 62 (2) 287-292; DOI: https://doi.org/10.2967/jnumed.120.245597

SNMMI Newsline

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    SNMMI Newsline
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 11N-22N;
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    FDA Approves First PSMA-Targeted PET Drug
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 11N;
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    2020 SNMMI Highlights Lecture: Neuroscience
    Julie Price
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 12N-19N;
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    SNMMI Leadership Update: Advancing Radiopharmaceutical Therapy
    Richard L. Wahl
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 20N;
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    FDA Announces Priority Review of 18F-DCFPyL NDA
    Journal of Nuclear Medicine February 1, 2021, 62 (2) 21N-22N;
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In this issue

Journal of Nuclear Medicine: 62 (2)
Journal of Nuclear Medicine
Vol. 62, Issue 2
February 1, 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author

Issue highlights

  • 18F-Fluoroestradiol PET Imaging in a Phase II Trial of Vorinostat to Restore Endocrine Sensitivity in ER+/HER2− Metastatic Breast Cancer
  • Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
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      • FEATURED ARTICLE OF THE MONTH
      • BRIEF COMMUNICATION
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  • Theranostics
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  • Neurology
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  • Initial Clinical Experience with 90Y-FAPI-46 Radioligand Therapy for Advanced-Stage Solid Tumors: A Case Series of 9 Patients
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  • MIRD Pamphlet No. 27: MIRDcell V3, a Revised Software Tool for Multicellular Dosimetry and Bioeffect Modeling
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