Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye–Protein Interaction

Albertus W. Hensbergen; Tessa Buckle; Danny M. van Willigen; Margret Schottelius; Mick M. Welling; Felicia A. van der Wijk; Tobias Maurer; Henk G. van der Poel; Gabri van der Pluijm; Wytske M. van Weerden; Hans-Jürgen Wester; Fijs W.B. van Leeuwen

doi:10.2967/jnumed.119.233064

Research ArticleTheranostics

Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye–Protein Interaction

Albertus W. Hensbergen, Tessa Buckle, Danny M. van Willigen, Margret Schottelius, Mick M. Welling, Felicia A. van der Wijk, Tobias Maurer, Henk G. van der Poel, Gabri van der Pluijm, Wytske M. van Weerden, Hans-Jürgen Wester and Fijs W.B. van Leeuwen

Journal of Nuclear Medicine February 2020, 61 (2) 234-241; DOI: https://doi.org/10.2967/jnumed.119.233064

Albertus W. Hensbergen

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Tessa Buckle

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Danny M. van Willigen

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Margret Schottelius

2Pharmazeutische Radiochemie, Technische Universität München, Garching, Germany

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Mick M. Welling

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Felicia A. van der Wijk

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Tobias Maurer

3Martini-Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

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Henk G. van der Poel

4Department of Urology, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

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Gabri van der Pluijm

5Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands; and

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Wytske M. van Weerden

6Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands

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Hans-Jürgen Wester

2Pharmazeutische Radiochemie, Technische Universität München, Garching, Germany

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Fijs W.B. van Leeuwen

1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

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Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye–Protein Interaction

Journal of Nuclear Medicine Feb 2020, 61 (2) 234-241; DOI: 10.2967/jnumed.119.233064

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Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye–Protein Interaction

Journal of Nuclear Medicine Feb 2020, 61 (2) 234-241; DOI: 10.2967/jnumed.119.233064

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Keywords

prostate cancer
prostate-specific membrane antigen
hybrid tracers
image-guided surgery
cyanine

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