FAP nuclear theranostics: Calais looks at the current state of scientific and industry interest in advancing imaging and therapy with fibroblast activation proteins targeting cancer-associated fibroblasts, a major constituent of tumor stroma.
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Spatial-temporal ordering of amyloid: Fantoni and colleagues summarize current research in detection of regional amyloid deposition patterns and the potential for staging amyloid pathology, including expanding applications of PET imaging.
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Steroid hormone receptor imaging: Kumar and colleagues highlight recent achievements in preclinical and clinical imaging of estrogen and progesterone receptors in breast cancer.
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Mutation patterns in radioiodine refractoriness: Liu and colleagues investigate the role of BRAF V600E and TERT promoter mutations, particularly in tandem, in loss of radioactive iodine avidity in recurrent papillary thyroid cancer.
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18F-DCFPyL versus Na18F: Rowe and colleagues undertake a head-to-head comparison of prostate-specific membrane antigen–targeted 18F-DCFPyL PET and Na18F PET to determine which is more sensitive for detection of lesions suggestive of bone metastases in prostate cancer.
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Reducing 68Ga PET/CT dose? Rauscher and colleagues explore the definition of a clinically useful lower limit of injected dose for 68Ga–prostate-specific membrane antigen–11 PET/CT imaging of prostate cancer.
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68Ga-PSMA-11 PET/MRI: Kranzbühler and colleagues focus on patients with biochemical recurrence of prostate cancer and prostate-specific antigen values ≤0.5 ng/mL to assess the detection rate for 68Ga-PSMA-11 PET/MRI.
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18F-JK-PSMA-7 PET/CT: Dietlein and colleagues assess the clinical utility of 18F-JK–prostate-specific membrane antigen–7 for PET/CT imaging of patients with prostate cancer and compare findings with those from 68Ga-PSMA-11 imaging.
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Advanced reconstruction for PSMA PET: Jansen and colleagues explore the impact of advanced PET image reconstruction methods on biochemically recurrent prostate cancer localization and interobserver agreement with 18F-DCFPyL PET/CT scans in patients with low prostate-specific antigen values.
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Tumor-to-blood ratio in NETs: Ilan and colleagues evaluate the tumor-to-blood ratio as an alternative tool for semiquantitative assessment of 68Ga-DOTATOC and 68Ga-DOTATATE tumor uptake and for therapy monitoring in patients with neuroendocrine tumors.
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177Lu-DOTATATE in NETS: Hope and members of the North American Neuroendocrine Tumor Society and SNMMI present a consensus statement on patient selection and appropriate use of 177Lu-DOTATATE peptide receptor radionuclide therapy in neuroendocrine tumors.
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Metal-ion labeled DOTATATE imaging: Andersen and colleagues compare 68Ga-DOTATATE, 64Cu-DOTATATE, and 55Co-DOTATATE PET/CT in mice to determine whether the 55Co label conveys advantages for imaging at delayed time points.
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Cyanine-spacer–based PSMA hybrid tracers: Hensbergen and colleagues describe development of a 99mTc-labeled prostate-specific membrane antigen–targeted tracer incorporating a fluorescent dye for radioguided surgery.
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TRT radiopharmaceuticals for mGluR1: Xie and colleagues describe 2 new radiopharmaceuticals, 131I-IITM and 211At-AITM, targeting the ectopic metabotropic glutamate receptor 1 in melanomas for radionuclide therapy studies.
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PET after cardiac transplantation: Miller and colleagues compare the diagnostic and prognostic utility of stress myocardial blood flow and myocardial flow reserve quantitation by PET in cardiac allograft vasculopathy after cardiac transplantation.
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Recovered mGluR5 in alcohol dependence: Ceccarini and colleagues research whether decreased cerebral metabotropic glutamate receptor 5 availability in alcohol-dependent patients normalizes during abstinence and whether initial 18F-FPEB mGluR5 imaging parameters can predict individual relapse.
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Tau PET in syntactic network disease: Pascual and colleagues study tau propagation patterns in the left hemispheric syntactic network in patients with nonfluent primary progressive aphasia.
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68Ga-RGD PET/CT and angiogenesis: Lobeek and colleagues detail the results of a clinical feasibility study designed to demonstrate that 68Ga-labeled arginine-glycine-aspartate tripeptide sequence PET/CT can be used to quantitatively assess angiogenesis in peripheral arteriovenous malformations.
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18F-FDG PET/MRI and CMRGlc mapping: Shiyam Sundar and colleagues describe a fully automated processing pipeline to support noninvasive absolute quantification of the cerebral metabolic rate for glucose in a clinical setting.
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Total-body parametric PET/CT imaging: Zhang and colleagues demonstrate the capability of total-body parametric imaging and quantify improvements in image quality and kinetic parameter estimation by direct and kernel reconstruction of uEXPLORER data.
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High-throughput small-animal PET/CT: Greenwood and colleagues report on development of a device to simultaneously image up to 4 mice, thereby reducing costs and maximizing radiotracer efficiency when compared with scans performed on a single mouse bed.
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Denoising nuclear medicine images: Minarik and colleagues investigate whether noise can be removed in whole-body bone scans using convolutional neural networks trained with sets of noisy and noiseless images obtained by Monte Carlo simulation.
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- © 2020 by the Society of Nuclear Medicine and Molecular Imaging.