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Research ArticleClinical Investigations

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai and Yukitsuka Kudo
Journal of Nuclear Medicine February 2016, 57 (2) 208-214; DOI: https://doi.org/10.2967/jnumed.115.164848
Ryuichi Harada
1Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
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Nobuyuki Okamura
1Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
2Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Shozo Furumoto
4Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Katsutoshi Furukawa
5Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and
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Aiko Ishiki
5Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and
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Naoki Tomita
5Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and
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Tetsuro Tago
4Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Kotaro Hiraoka
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Shoichi Watanuki
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Miho Shidahara
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
6Division of Medical Physics, Tohoku University School of Medicine, Sendai, Japan
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Masayasu Miyake
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Yoichi Ishikawa
4Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Rin Matsuda
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Akie Inami
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Takeo Yoshikawa
2Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
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Yoshihito Funaki
4Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Ren Iwata
4Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Manabu Tashiro
3Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Kazuhiko Yanai
2Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
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Hiroyuki Arai
5Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and
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Yukitsuka Kudo
1Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
4Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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Journal of Nuclear Medicine: 57 (2)
Journal of Nuclear Medicine
Vol. 57, Issue 2
February 1, 2016
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18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
Journal of Nuclear Medicine Feb 2016, 57 (2) 208-214; DOI: 10.2967/jnumed.115.164848

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18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
Journal of Nuclear Medicine Feb 2016, 57 (2) 208-214; DOI: 10.2967/jnumed.115.164848
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  • Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers
  • Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers
  • First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis
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  • Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging
  • In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET
  • Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles
  • Hybrid PET/MR Imaging in Neurology: Present Applications and Prospects for the Future
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Keywords

  • Alzheimer’s disease
  • tau
  • PET
  • radiotracer
  • 18F-THK5351
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