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Research ArticleClinical Investigations

Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma

Marleen Keyaerts, Catarina Xavier, Johannes Heemskerk, Nick Devoogdt, Hendrik Everaert, Chloé Ackaert, Marian Vanhoeij, Francois P. Duhoux, Thierry Gevaert, Philippe Simon, Denis Schallier, Christel Fontaine, Ilse Vaneycken, Christian Vanhove, Jacques De Greve, Jan Lamote, Vicky Caveliers and Tony Lahoutte
Journal of Nuclear Medicine January 2016, 57 (1) 27-33; DOI: https://doi.org/10.2967/jnumed.115.162024
Marleen Keyaerts
1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
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Catarina Xavier
2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
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Johannes Heemskerk
1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
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Nick Devoogdt
2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
3Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
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Hendrik Everaert
1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
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Chloé Ackaert
3Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
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Marian Vanhoeij
4Department of Oncological Surgery, UZ Brussel, Brussels, Belgium
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Francois P. Duhoux
5Medical Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium
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Thierry Gevaert
6Department of Radiation Therapy, UZ Brussel, Brussels, Belgium
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Philippe Simon
7Gynecology Senology, Université Libre de Bruxelles Hôpital Erasme, Brussels, Belgium
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Denis Schallier
8Department of Medical Oncology, UZ Brussel, Brussels, Belgium; and
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Christel Fontaine
8Department of Medical Oncology, UZ Brussel, Brussels, Belgium; and
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Ilse Vaneycken
1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
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Christian Vanhove
9Infinity Laboratory, MEDISIP, IbiTech, Ghent University, and iMinds Medical IT, Ghent, Belgium
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Jacques De Greve
8Department of Medical Oncology, UZ Brussel, Brussels, Belgium; and
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Jan Lamote
4Department of Oncological Surgery, UZ Brussel, Brussels, Belgium
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Vicky Caveliers
1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
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Tony Lahoutte
1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
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Article Information

vol. 57 no. 1 27-33
DOI 
https://doi.org/10.2967/jnumed.115.162024
PubMed 
26449837

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 12, 2015
  • Accepted for publication October 1, 2015
  • Published online January 4, 2016.

Article Versions

  • previous version (October 8, 2015 - 06:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Marleen Keyaerts*,1,2,
  2. Catarina Xavier*,2,
  3. Johannes Heemskerk1,
  4. Nick Devoogdt2,3,
  5. Hendrik Everaert1,
  6. Chloé Ackaert3,
  7. Marian Vanhoeij4,
  8. Francois P. Duhoux5,
  9. Thierry Gevaert6,
  10. Philippe Simon7,
  11. Denis Schallier8,
  12. Christel Fontaine8,
  13. Ilse Vaneycken1,2,
  14. Christian Vanhove9,
  15. Jacques De Greve8,
  16. Jan Lamote4,
  17. Vicky Caveliers1,2 and
  18. Tony Lahoutte1,2
  1. 1Nuclear Medicine Department, UZ Brussel, Brussels, Belgium
  2. 2In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
  3. 3Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
  4. 4Department of Oncological Surgery, UZ Brussel, Brussels, Belgium
  5. 5Medical Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium
  6. 6Department of Radiation Therapy, UZ Brussel, Brussels, Belgium
  7. 7Gynecology Senology, Université Libre de Bruxelles Hôpital Erasme, Brussels, Belgium
  8. 8Department of Medical Oncology, UZ Brussel, Brussels, Belgium; and
  9. 9Infinity Laboratory, MEDISIP, IbiTech, Ghent University, and iMinds Medical IT, Ghent, Belgium
  1. For correspondence or reprints contact: Marleen Keyaerts, Nuclear Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail: marleen.keyaerts{at}vub.ac.be
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Journal of Nuclear Medicine: 57 (1)
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Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma
Marleen Keyaerts, Catarina Xavier, Johannes Heemskerk, Nick Devoogdt, Hendrik Everaert, Chloé Ackaert, Marian Vanhoeij, Francois P. Duhoux, Thierry Gevaert, Philippe Simon, Denis Schallier, Christel Fontaine, Ilse Vaneycken, Christian Vanhove, Jacques De Greve, Jan Lamote, Vicky Caveliers, Tony Lahoutte
Journal of Nuclear Medicine Jan 2016, 57 (1) 27-33; DOI: 10.2967/jnumed.115.162024

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Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma
Marleen Keyaerts, Catarina Xavier, Johannes Heemskerk, Nick Devoogdt, Hendrik Everaert, Chloé Ackaert, Marian Vanhoeij, Francois P. Duhoux, Thierry Gevaert, Philippe Simon, Denis Schallier, Christel Fontaine, Ilse Vaneycken, Christian Vanhove, Jacques De Greve, Jan Lamote, Vicky Caveliers, Tony Lahoutte
Journal of Nuclear Medicine Jan 2016, 57 (1) 27-33; DOI: 10.2967/jnumed.115.162024
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