Research ArticleBrief Communication

Parametric Images of Myocardial Viability Using a Single 15O-H2O PET/CT Scan

Hendrik J. Harms, Stefan de Haan, Paul Knaapen, Cornelis P. Allaart, Adriaan A. Lammertsma and Mark Lubberink
Journal of Nuclear Medicine May 2011, 52 (5) 745-749; DOI: https://doi.org/10.2967/jnumed.110.085431

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Example of short-axis fractional blood volume (A and C) and ATF (B and D) images obtained from 15O-CO (A and B) and fitted blood volume fraction (C and D) images of same patient. Images were obtained using stand-alone PET scanner and 10-mm gaussian filter. Also shown is example of short-axis fractional blood volume (E) and ATF (F) images obtained using clinical PET/CT scanner and fitted blood volume fraction images.

  • FIGURE 2.
    FIGURE 2.

    Correlation between segmental PTI, obtained using stand-alone PET scanner, based on fitted 15O-H2O blood volume fraction and 15O-CO blood volume images (A) with corresponding Bland–Altman plot (B).

  • FIGURE 3.
    FIGURE 3.

    Parametric PTIVb image obtained using PET/CT scanner (A) and corresponding DCE MR image (B) of typical patient with myocardial infarction, indicated by reduced PTIVb and hyperenhancement in DCE MR image. Arrows indicate myocardial infarction.

  • FIGURE 4.
    FIGURE 4.

    Correlation between average segmental PTI and PTI obtained using NLR (PTINLR) of segmental time–activity curves (A), with corresponding Bland–Altman plot (B) obtained using PET/CT scanner.

Tables

  • TABLE 1

    COV (%) and Relative Bias (%) Derived from Simulations (n = 1,000 for Each Condition) of Scar and Healthy (PTI = 0.5 and 1.0, Respectively) Tissue

    ScarHealthy
    MethodROIVoxelROIVoxel
    NLR
     COV1.447.051.608.82
     Bias−0.04−0.82−0.10−0.33
    BFM
     COV2.1610.431.778.88
     Bias0.091.14−0.12−0.36

    • ROI and voxel noise levels were 4% and 20%, respectively.

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