RT Journal Article
SR Electronic
T1 Parametric Images of Myocardial Viability Using a Single <sup>15</sup>O-H<sub>2</sub>O PET/CT Scan
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 745
OP 749
DO 10.2967/jnumed.110.085431
VO 52
IS 5
A1 Harms, Hendrik J.
A1 de Haan, Stefan
A1 Knaapen, Paul
A1 Allaart, Cornelis P.
A1 Lammertsma, Adriaan A.
A1 Lubberink, Mark
YR 2011
UL http://jnm.snmjournals.org/content/52/5/745.abstract
AB Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, 15O-CO, and 15O-H2O scans. The aim of this study was to generate parametric PTI images from a 15O-H2O PET/CT scan without an additional 15O-CO scan. Methods: Data from 20 patients undergoing both 15O-H2O and 15O-CO scans were used, assessing correlation between PTI based on 15O-CO (PTICO) and on fitted blood volume fractions (PTIVb). In addition, parametric PTIVb images of 10 patients undergoing 15O-H2O PET/CT scans were generated using basis-function methods and compared with PTIVb obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTIVb. Results: Correlation between PTICO and PTIVb was high (r2 = 0.73). Parametric PTIVb correlated well with PTIVb obtained using nonlinear regression (r2 = 0.91). Simulations showed low sensitivity to noise (coefficient of variation &lt; 10% at 20% noise). Conclusion: Parametric PTI images can be generated from a single 15O-H2O PET/CT scan.