PT - JOURNAL ARTICLE AU - Harms, Hendrik J. AU - de Haan, Stefan AU - Knaapen, Paul AU - Allaart, Cornelis P. AU - Lammertsma, Adriaan A. AU - Lubberink, Mark TI - Parametric Images of Myocardial Viability Using a Single <sup>15</sup>O-H<sub>2</sub>O PET/CT Scan AID - 10.2967/jnumed.110.085431 DP - 2011 May 01 TA - Journal of Nuclear Medicine PG - 745--749 VI - 52 IP - 5 4099 - http://jnm.snmjournals.org/content/52/5/745.short 4100 - http://jnm.snmjournals.org/content/52/5/745.full SO - J Nucl Med2011 May 01; 52 AB - Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, 15O-CO, and 15O-H2O scans. The aim of this study was to generate parametric PTI images from a 15O-H2O PET/CT scan without an additional 15O-CO scan. Methods: Data from 20 patients undergoing both 15O-H2O and 15O-CO scans were used, assessing correlation between PTI based on 15O-CO (PTICO) and on fitted blood volume fractions (PTIVb). In addition, parametric PTIVb images of 10 patients undergoing 15O-H2O PET/CT scans were generated using basis-function methods and compared with PTIVb obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTIVb. Results: Correlation between PTICO and PTIVb was high (r2 = 0.73). Parametric PTIVb correlated well with PTIVb obtained using nonlinear regression (r2 = 0.91). Simulations showed low sensitivity to noise (coefficient of variation &lt; 10% at 20% noise). Conclusion: Parametric PTI images can be generated from a single 15O-H2O PET/CT scan.