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Journal of Nuclear Medicine

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OtherFOCUS ON MOLECULAR IMAGING

PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications

Bernd J. Pichler, Armin Kolb, Thomas Nägele and Heinz-Peter Schlemmer
Journal of Nuclear Medicine March 2010, 51 (3) 333-336; DOI: https://doi.org/10.2967/jnumed.109.061853
Bernd J. Pichler
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Armin Kolb
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Thomas Nägele
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Heinz-Peter Schlemmer
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  • FIGURE 1. 
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    FIGURE 1. 

    PET/CT and PET/MRI of 71-y-old woman with frontobasal meningioma in olfactory region. PET/CT images were acquired 20 min and PET/MR images 100 min after injection of 135 MBq of 68Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N″′-tetraacetic acid]-d-Phe1,Tyr3-octreotide. Tracer uptake in the tumor is seen on PET images. In addition, second smaller and previously unknown frontal meningioma was seen on PET and possibly corresponded to small mass demonstrated on T2-weighted turbo spin-echo MR images. This finding was not detected by CT.

  • FIGURE 2. 
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    FIGURE 2. 

    A 36-y-old patient with brain gliomatosis was admitted for tumor biopsy. In addition to standard contrast-enhanced T1-weighted MRI (left), chemical shift imaging (CSI) (echo time = 135 ms, center) and PET/MRI with 11C-methionine (right) were performed. On standard MRI, no contrast enhancement in any part of tumor was found, indicating low-grade tumor. On CSI, mapping of choline/N-acetylaspartate (Cho/NAA) quotient showed hot spot in right insular region, whereas 11C-methionine uptake was most pronounced in basal frontal lobe on left side. Because of discrepancy between CSI and PET/MRI, biopsy was performed in both locations and revealed anaplastic glioma (World Health Organization grade III) in frontal left region and low-grade glioma (World Health Organization grade II) in right insular region. CA = contrast agent.

  • FIGURE 3. 
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    FIGURE 3. 

    Abdominal unenhanced 18F-FDG PET/CT and MRI of 55-y-old woman with ovarian cancer showing liver metastases detected by MRI (C) but neither by PET (B) nor native CT (A). MRI is most sensitive for detecting small liver lesions because of its superb soft-tissue contrast, whereas PET and CT are limited because of lower contrast and physiologic 18F-FDG liver uptake.

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Journal of Nuclear Medicine: 51 (3)
Journal of Nuclear Medicine
Vol. 51, Issue 3
March 2010
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PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications
Bernd J. Pichler, Armin Kolb, Thomas Nägele, Heinz-Peter Schlemmer
Journal of Nuclear Medicine Mar 2010, 51 (3) 333-336; DOI: 10.2967/jnumed.109.061853

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PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications
Bernd J. Pichler, Armin Kolb, Thomas Nägele, Heinz-Peter Schlemmer
Journal of Nuclear Medicine Mar 2010, 51 (3) 333-336; DOI: 10.2967/jnumed.109.061853
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  • Article
    • Abstract
    • PET/MRI: TECHNICAL EVOLUTION
    • CLINICAL POTENTIAL OF PET/MRI
    • WHOLE-BODY PET/MRI
    • CONCLUSION
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