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Journal of Nuclear Medicine

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Research ArticleCLINICAL INVESTIGATIONS

Evaluation of the Accumulation of 11C-Methionine with Standardized Uptake Value in the Normal Brain

Takehiro Uda, Naohiro Tsuyuguchi, Yuzo Terakawa, Toshihiro Takami and Kenji Ohata
Journal of Nuclear Medicine February 2010, 51 (2) 219-222; DOI: https://doi.org/10.2967/jnumed.109.068783
Takehiro Uda
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Naohiro Tsuyuguchi
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Yuzo Terakawa
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Toshihiro Takami
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Kenji Ohata
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  • FIGURE 1. 
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    FIGURE 1. 

    11C-methionine PET images in healthy subject. ROIs were enclosed manually in frontal cortex (F), parietal cortex (P), cerebellum (C), and brain stem (B).

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    FIGURE 2. 

    w-SUVs in different parts of brain are shown as box-and-whisker plots. Box plots indicate upper and lower quartiles, median, and range. Error bars indicate farthest points that are not outliers. Significant differences were observed between frontal cortex and cerebellum, frontal cortex and brain stem, parietal cortex and cerebellum, and parietal cortex and brain stem (P < 0.01).

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    FIGURE 3. 

    Regression analysis and scatter graph for analysis of age-associated changes in w-SUV. Although slightly negative linear regression was suggested between aging and SUV, P value of regression coefficient was not statistically significant (P = 0.485).

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    FIGURE 4. 

    Symmetric percentage changes between first and second PET analyses in w-SUV and s-SUV are shown as box-and-whisker plots. Box plots indicate upper and lower quartiles, median, and range. Error bars indicate farthest points that are not outliers.

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    TABLE 1

    Patient Characteristics

    CharacteristicSteps 1–3Step 4
    Sex (n)
     Male2513
     Female389
    Age (y)
     Mean43.546.5
     Median4445
    Diagnosis (n)
     Low-grade glioma1213
     Pituitary tumor6
     Meningioma62
     Intracranial cyst4
     Metastatic brain tumor35
     Chordoma2
     Neurinoma1
     Other intracranial tumor92
     Others15
    Healthy volunteer (n)5
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Journal of Nuclear Medicine: 51 (2)
Journal of Nuclear Medicine
Vol. 51, Issue 2
February 2010
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Evaluation of the Accumulation of 11C-Methionine with Standardized Uptake Value in the Normal Brain
Takehiro Uda, Naohiro Tsuyuguchi, Yuzo Terakawa, Toshihiro Takami, Kenji Ohata
Journal of Nuclear Medicine Feb 2010, 51 (2) 219-222; DOI: 10.2967/jnumed.109.068783

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Evaluation of the Accumulation of 11C-Methionine with Standardized Uptake Value in the Normal Brain
Takehiro Uda, Naohiro Tsuyuguchi, Yuzo Terakawa, Toshihiro Takami, Kenji Ohata
Journal of Nuclear Medicine Feb 2010, 51 (2) 219-222; DOI: 10.2967/jnumed.109.068783
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