TY - JOUR T1 - Evaluation of the Accumulation of <sup>11</sup>C-Methionine with Standardized Uptake Value in the Normal Brain JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 219 LP - 222 DO - 10.2967/jnumed.109.068783 VL - 51 IS - 2 AU - Takehiro Uda AU - Naohiro Tsuyuguchi AU - Yuzo Terakawa AU - Toshihiro Takami AU - Kenji Ohata Y1 - 2010/02/01 UR - http://jnm.snmjournals.org/content/51/2/219.abstract N2 - The aim of this study was to determine the normal l-[methyl-11C]-methionine (11C-methionine) uptake and the extent of variation using standardized uptake value (SUV). Methods: Five healthy volunteers and 58 adult patients with normal 11C-methionine uptake were included in the interindividual analysis and 22 patients in the intraindividual analysis. SUVs in different brain regions, age-associated changes, correlation between 2 correction methods (for body weight [w-SUV] or body surface area [s-SUV]), and intraindividual reproducibility were examined. Results: w-SUVs were statistically different between the brain regions. The frontal or parietal cortex showed lower coefficients of variation than did the cerebellum or brain stem. There was no significant age-associated change. w-SUVs showed lower coefficients of variation in interindividual analysis and lower symmetric percentage change in intraindividual reproducibility than did s-SUVs. Conclusion: SUVs in the normal brain show inter- and intraindividual variation, and our proposed normal w-SUVs represent an important reference value. ER -