PT  - JOURNAL ARTICLE
AU  - Takehiro Uda
AU  - Naohiro Tsuyuguchi
AU  - Yuzo Terakawa
AU  - Toshihiro Takami
AU  - Kenji Ohata
TI  - Evaluation of the Accumulation of <sup>11</sup>C-Methionine with Standardized Uptake Value in the Normal Brain
AID  - 10.2967/jnumed.109.068783
DP  - 2010 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 219--222
VI  - 51
IP  - 2
4099  - http://jnm.snmjournals.org/content/51/2/219.short
4100  - http://jnm.snmjournals.org/content/51/2/219.full
SO  - J Nucl Med2010 Feb 01; 51
AB  - The aim of this study was to determine the normal l-[methyl-11C]-methionine (11C-methionine) uptake and the extent of variation using standardized uptake value (SUV). Methods: Five healthy volunteers and 58 adult patients with normal 11C-methionine uptake were included in the interindividual analysis and 22 patients in the intraindividual analysis. SUVs in different brain regions, age-associated changes, correlation between 2 correction methods (for body weight [w-SUV] or body surface area [s-SUV]), and intraindividual reproducibility were examined. Results: w-SUVs were statistically different between the brain regions. The frontal or parietal cortex showed lower coefficients of variation than did the cerebellum or brain stem. There was no significant age-associated change. w-SUVs showed lower coefficients of variation in interindividual analysis and lower symmetric percentage change in intraindividual reproducibility than did s-SUVs. Conclusion: SUVs in the normal brain show inter- and intraindividual variation, and our proposed normal w-SUVs represent an important reference value.