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OtherClinical Investigations

Lymphoscintigraphy for Sentinel Node Mapping Using a Hybrid SPECT/CT System

Einat Even-Sapir, Hedva Lerman, Genady Lievshitz, Avi Khafif, Dan M. Fliss, Arnon Schwartz, Eyal Gur, Yehuda Skornick and Shlomo Schneebaum
Journal of Nuclear Medicine September 2003, 44 (9) 1413-1420;
Einat Even-Sapir
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Hedva Lerman
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Genady Lievshitz
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Avi Khafif
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Dan M. Fliss
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Arnon Schwartz
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Eyal Gur
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Yehuda Skornick
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Shlomo Schneebaum
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  • FIGURE 1.
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    FIGURE 1.

    Patient with cutaneous malignant melanoma in chest wall. SN hidden by scattered radiation of injection site. Multiprojection planar lymphoscintigraphy failed to identify SN (top images: selected planar images in anterior and lateral projections). On fused SPECT/CT images, hot node was identified in axilla (bottom images: transaxial and sagittal slices).

  • FIGURE 2.
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    FIGURE 2.

    Patient with cutaneous malignant melanoma in right upper back. SNs in multiple basins. Multiprojection planar images identified hot node in axilla (bottom right image: anterior projection). Fused SPECT/CT images identified additional supraclavicular and low jugular nodes (top: transaxial slices; bottom left: coronal slices).

  • FIGURE 3.
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    FIGURE 3.

    Patient with melanoma in back. Anterior (bottom left) and lateral (bottom right) planar images detect multiple nodes. Transaxial SPECT/CT images (top) localize nodes in anterior axilla and in aberrant superficial location.

Tables

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    TABLE 1

    Scintigraphic and Histopathologic Findings in Patients with Tumor Localized in Head and Neck Region

    Patient no.Age (y)SexTumor type and locationPlanar imaging*Localization of nodes seen on planar imagingSPECT/CT imagingSurgical and histopathologic results
    First nodes detectedAdditional nodesSingle vs. multiple basinsAdditional nodes†Single vs. multiple basinsClinically relevant added value‡
    170MSCC, tongueMidjugularSupraclavicularUnclearMid- and lower jugular chain+ jugulo-digastric (hidden)Multiple+Positive SN (cervical)
    250FSCC, tongueHigh jugular4 along jugular chainSingleJugular chain+ submental (hidden)Single+Negative
    343MSCC, tongueHigh jugular1 midjugularSingleJugular chain−Single−Positive SN (cervical)
    472MSCC, tongueSupraclavicular, suspected submandibular−UnclearSupraclavicularSecond node was ruled out (injection site)Single+Positive SN (supraclavicular)
    527MSCC, tongueHigh jugular3 along jugular chainSingleJugular chain+ posterior cervical triangleMultiple+Multiple involved nodes
    654MSCC, oral mucosaHigh jugular4 along jugular chainSingleJugular chain−Single−Negative
    781MMM, head2 preauricular2 submandibularUnclear2 preauricular, 1 submandibular, 1 jugulodigastric−Unclear−Negative
    867MMM, scalpFaint occipital−SinglePosterior cervical triangle−Single−Multiple involved nodes
    955MMM, scalpHigh jugular, contralateral occipital1 cervicalMultiple2 jugular, 2 contralateral occipital−Multiple−Negative
    • ↵* Including images obtained with 57Co flood source.

    • ↵† Additional nodes detected on SPECT/CT only. Hidden = hidden by scatter radiation of injection site.

    • ↵‡ SPECT/CT added data were considered clinically relevant if they guided surgeon to SNs that were undetected on planar images or to SNs in another basin.

    • MM = malignant melanoma.

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    TABLE 2

    Scintigraphic and Histopathologic Findings in Patients with Malignant Melanoma of Trunk

    Patient no.Age (y)SexTumor type and locationPlanar imaging*Localization of nodes seen on planar imagingSPECT/CT imagingSurgical and histopathologic results
    First nodes detectedAdditional nodesSingle vs. multiple basinsAdditional nodes†Single vs. multiple basinsClinically relevant added value‡
    152ML shoulderL axilla−SingleL axilla, central−Single−Negative
    224MR shoulderR axilla−SingleApical, R axilla+ (IT)Single+Negative
    373MMidupper backL axilla2 L axilla, 1 R axillaMultipleIn L axilla, 1 subscapular node and 1 central node+ pectoral nodeMultiple+Negative
    461ML upper backL axilla2 L axillaUnclear2 central, 1 pectoral axillary node+ prescapular (IT)Multiple+Negative
    571MR upper backR axilla2 R axillaSingleCentral axillary nodes−Single−Negative
    667MMidupper backL jugular chain, 2 nodesL axilla, L occipitalMultipleL jugular, axillary, and occipital nodes−Multiple−Negative
    759FMidupper backL axillaL axillaSingleCentral axillary nodes−Single−1 positive SN node (axillary)
    852FMidupper backR axilla, 2 nodesL axilla, 2 nodesMultipleBilateral central axillary nodes−Multiple−Negative
    960MR upper backR axilla−Single1 axillary central node+ supraclavicular node, low jugular nodeMultiple+Negative
    1055MMidlower backL axillaL groinMultipleL central axilla node, L groin node−Multiple−1 positive node (groin)
    1162MChest wall−−−−+ 1 central axillary node (hidden)Single+Negative
    1226FAbdominal wallL groin, aberrant uptake−UnclearL groin+ (?) parailiac nodes, aberrant uptakeUnclear−Negative (parailiac nodes and aberrant uptake not examined)
    • ↵* Including images obtained with 57Co flood source.

    • ↵† Additional nodes detected on SPECT/CT only. Hidden = hidden by scatter radiation of injection site; IT = in-transit.

    • ↵‡ SPECT/CT added data were considered clinically relevant if they guided surgeon to SNs that were undetected on planar images or to SNs in another basin.

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Journal of Nuclear Medicine
Vol. 44, Issue 9
September 1, 2003
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Lymphoscintigraphy for Sentinel Node Mapping Using a Hybrid SPECT/CT System
Einat Even-Sapir, Hedva Lerman, Genady Lievshitz, Avi Khafif, Dan M. Fliss, Arnon Schwartz, Eyal Gur, Yehuda Skornick, Shlomo Schneebaum
Journal of Nuclear Medicine Sep 2003, 44 (9) 1413-1420;

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Lymphoscintigraphy for Sentinel Node Mapping Using a Hybrid SPECT/CT System
Einat Even-Sapir, Hedva Lerman, Genady Lievshitz, Avi Khafif, Dan M. Fliss, Arnon Schwartz, Eyal Gur, Yehuda Skornick, Shlomo Schneebaum
Journal of Nuclear Medicine Sep 2003, 44 (9) 1413-1420;
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