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OtherBasic Science Investigations

Automated 3-Dimensional Registration of Stand-Alone 18F-FDG Whole-Body PET with CT

Piotr J. Slomka, Damini Dey, Christian Przetak, Usaf E. Aladl and Richard P. Baum
Journal of Nuclear Medicine July 2003, 44 (7) 1156-1167;
Piotr J. Slomka
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Damini Dey
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Christian Przetak
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Usaf E. Aladl
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Richard P. Baum
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Figures

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  • FIGURE 1.
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    FIGURE 1.

    Flow chart with steps performed during automatic image registration.

  • FIGURE 2.
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    FIGURE 2.

    Automatically identified landmarks on segmented CT (left) and segmented transmission map (right) identified by algorithm for nonlinear step (A) and resulting displacement vectors created by joining corresponding CT and transmission map landmarks (B).

  • FIGURE 3.
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    FIGURE 3.

    Errors in translational parameters after image registration as function of initial translational (A) and rotational (B) image misalignment.

  • FIGURE 4.
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    FIGURE 4.

    Results of registration in case of deep-inspiration CT acquisition registered with normal-breathing PET (A) and normal breathing during CT and PET acquisition (B). In both cases, only linear registration module was used without warping correction.

  • FIGURE 5.
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    FIGURE 5.

    Example of warping artifact due to opposite displacement vectors in close proximity (left) and result of median filtering (right). Arrows indicate location of artifact.

  • FIGURE 6.
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    FIGURE 6.

    Final registration results in case of large diaphragmatic displacement shown on transmission–CT fusion images before warping (A) and after warping has been applied (B).

  • FIGURE 7.
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    FIGURE 7.

    Final registration results in case shown on emission PET/CT fusion images before warping (left) and after warping applied (right).

Tables

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    TABLE 1

    Reproducibility of TR, EM, and TR+EM Image Registration

    DataTranslationScalingRotation
    TR+EM0.3 ± 0.51.1 ± 1.60.3 ± 0.2
    TR0.3 ± 0.41.1 ± 1.50.2 ± 0.5
    EM0.3 ± 0.41.8 ± 2.20.4 ± 0.4
    • Units of reproducibility are pixels for translations, % for scaling, and degrees for rotation.

    • View popup
    TABLE 2

    Reproducibility of Image Registration Using MI and NMI Criteria

    CriteriaTranslationScalingRotation
    MI0.3 ± 0.51.1 ± 1.60.3 ± 0.2
    NMI0.4 ± 0.61.5 ± 1.70.3 ± 0.4
    • Units of reproducibility are pixels for translations, % for scaling, and degrees for rotation.

    • View popup
    TABLE 3

    Performance of Algorithm for Various Multiresolution Levels

    ParameterMulti-res1Multi-res2Multi-res4
    Time (s)363 ± 187290 ± 89189 ± 106
    Iterations204 ± 85351 ± 77598 ± 104
    • View popup
    TABLE 4

    Lung Volumes Measured on Segmented CT Scans, Original Transmission Scans, and Warped Transmission Scans

    ScanLung volume (L)
    RightLeft
    CT2.2 ± 1.01.8 ± 0.5
    Transmission1.7 ± 0.41.5 ± 0.4
    Warped transmission2.2 ± 0.71.9 ± 0.5
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Journal of Nuclear Medicine
Vol. 44, Issue 7
July 1, 2003
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Automated 3-Dimensional Registration of Stand-Alone 18F-FDG Whole-Body PET with CT
Piotr J. Slomka, Damini Dey, Christian Przetak, Usaf E. Aladl, Richard P. Baum
Journal of Nuclear Medicine Jul 2003, 44 (7) 1156-1167;

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Automated 3-Dimensional Registration of Stand-Alone 18F-FDG Whole-Body PET with CT
Piotr J. Slomka, Damini Dey, Christian Przetak, Usaf E. Aladl, Richard P. Baum
Journal of Nuclear Medicine Jul 2003, 44 (7) 1156-1167;
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