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OtherBasic Science Investigations

Monitoring Tumor Cell Proliferation by Targeting DNA Synthetic Processes with Thymidine and Thymidine Analogs

Jeffrey L. Schwartz, Yasuko Tamura, Robert Jordan, John R. Grierson and Kenneth A. Krohn
Journal of Nuclear Medicine December 2003, 44 (12) 2027-2032;
Jeffrey L. Schwartz
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Yasuko Tamura
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Robert Jordan
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John R. Grierson
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Kenneth A. Krohn
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Article Information

vol. 44 no. 12 2027-2032
PubMed 
14660729

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Published online December 5, 2003.

Copyright & Usage 
THE JOURNAL OF NUCLEAR MEDICINE

Author Information

  1. Jeffrey L. Schwartz, PhD1,
  2. Yasuko Tamura, BS1,
  3. Robert Jordan, BS1,
  4. John R. Grierson, PhD2 and
  5. Kenneth A. Krohn, PhD1,2
  1. 1Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington
  2. 2Department of Radiology, University of Washington School of Medicine, Seattle, Washington
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Journal of Nuclear Medicine
Vol. 44, Issue 12
December 1, 2003
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Monitoring Tumor Cell Proliferation by Targeting DNA Synthetic Processes with Thymidine and Thymidine Analogs
Jeffrey L. Schwartz, Yasuko Tamura, Robert Jordan, John R. Grierson, Kenneth A. Krohn
Journal of Nuclear Medicine Dec 2003, 44 (12) 2027-2032;

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Monitoring Tumor Cell Proliferation by Targeting DNA Synthetic Processes with Thymidine and Thymidine Analogs
Jeffrey L. Schwartz, Yasuko Tamura, Robert Jordan, John R. Grierson, Kenneth A. Krohn
Journal of Nuclear Medicine Dec 2003, 44 (12) 2027-2032;
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  • Pharmacodynamic Study Using FLT PET/CT in Patients with Renal Cell Cancer and Other Solid Malignancies Treated with Sunitinib Malate
  • Antitumor Activity of Ridaforolimus and Potential Cell-Cycle Determinants of Sensitivity in Sarcoma and Endometrial Cancer Models
  • Gastric Cancer Growth Control by BEZ235 In Vivo Does Not Correlate with PI3K/mTOR Target Inhibition but with [18F]FLT Uptake
  • Tumor 3'-Deoxy-3'-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors
  • Quantitative Analysis of Thymidine Kinase 1 and 5'(3')-Deoxyribonucleotidase mRNA Expression: The Role of Fluorothymidine Uptake
  • Different Modes of Transport for 3H-Thymidine, 3H-FLT, and 3H-FMAU in Proliferating and Nonproliferating Human Tumor Cells
  • Noninvasive Imaging of Endogenous Neural Stem Cell Mobilization In Vivo Using Positron Emission Tomography
  • Radiopharmaceuticals in Preclinical and Clinical Development for Monitoring of Therapy with PET
  • Changes in Tumor Metabolism as Readout for Mammalian Target of Rapamycin Kinase Inhibition by Rapamycin in Glioblastoma
  • 3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition
  • Imaging-Guided Gene Therapy of Experimental Gliomas
  • 18F-Fluoro-L-Thymidine and 11C-Methylmethionine as Markers of Increased Transport and Proliferation in Brain Tumors
  • Reproducibility of 3'-Deoxy-3'-18F-Fluorothymidine MicroPET Studies in Tumor Xenografts in Mice
  • Comparison of 18F-FLT PET and 18F-FDG PET in Esophageal Cancer
  • Kinetic Modeling of 3'-Deoxy-3'-Fluorothymidine in Somatic Tumors: Mathematical Studies
  • Kinetic Analysis of 3'-Deoxy-3'-Fluorothymidine PET Studies: Validation Studies in Patients with Lung Cancer
  • Monitoring Antiproliferative Responses to Kinase Inhibitor Therapy in Mice with 3'-Deoxy-3'-18F-Fluorothymidine PET
  • Head and Neck Cancer: Meeting Summary and Research Opportunities
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