Dual Time Point 18F-FDG PET for the Evaluation of Pulmonary Nodules

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
FIGURE 1.
A 72-y-old woman presented with right lower lobe nodule measuring 1.8 × 1.0 cm. SUV increased from 1.45 on scan 1 at 65 min after injection (A) to 1.72 on scan 2 at 123 min after injection (B). Biopsy of lesion revealed moderately differentiated adenocarcinoma.
Download figure
Open in new tab
Download powerpoint
FIGURE 2.
A 69-y-old woman presented with 0.8-cm density in left upper lobe. SUV was not significantly different between scan 1 at 54 min after injection (A), where SUV was 1.54, and scan 2 at 100 min after injection (B), where SUV was 1.50. Excised lesion was granuloma.

TABLE 1

Patients with Malignant Lesions

Lesion no.	Patient’s age (y)	Patient’s sex	Lesion size (cm)/location	Follow-up/pathology	SUV1*	SUV2^†	% Change^‡
1	78	F	2.5/RLL	Adenocarcinoma (Bx)	3.10	4.00	29.0
2	71	M	2.0/LUL	Adenocarcinoma (Res)	1.12	1.33	18.8
3	79	M	4.2/RUL	Adenocarcinoma (Res)	4.64	5.56	19.1
4	75	M	3.0/RUL	Adenocarcinoma (Bx)	4.72	5.38	14.0
5	73	F	2.4 × 2.1/LLL^§	SCC (Bx)	8.34	10.53	26.3
6			1.8/LLL^\|	SCC (Bx)	4.58	5.97	30.3
7	69	F	1.5/RUL	Adenocarcinoma (Bx)	1.69	2.18	29.0
8	75	M	2.0/LUL	Adenocarcinoma (Res)	1.22	1.36	11.5
9	63	F	1.8 × 1.0/RLL	Adenocarcinoma (Bx)	1.45	1.72	18.6
10	88	F	3.5 × 5.0/LLL	Adenocarcinoma (Bx)	7.06	8.24	16.7
11	83	M	3.4 × 2.7/RUL	Adenocarcinoma (Res)	3.09	4.27	38.2
12	54	F	0.6/LUL	Probable lung cancer: no Bx, but response to XRT	2.80	3.21	14.6
13	73	F	1.7 × 1.4/RUL	SCC (Res)	2.60	2.87	10.4
14	70	F	6.0/RUL	SCC (Res)	5.23	5.93	13.4
15	71	M	3.5 × 2.5/LUL	Metastasis from prostate cancer (Bx)	2.57	2.90	12.8
16	67	M	2.5/RML	Adenocarcinoma (Bx)	2.54	3.08	21.3
17	68	M	4.0 × 3.0/LUL	Adenocarcinoma (Bx)	3.35	4.36	30.1
18	71	F	1.9 × 1.2/RUL	SCC (Bx)	3.63	4.08	12.4
19	83	F	2.8 × 2.7/LUL	Adenocarcinoma (Bx)	3.12	3.56	14.1
20	67	F	3.0 × 3.0/RUL	Adenocarcinoma (Res)	6.25	8.04	28.6

↵* Mean ± SD of SUV1 = 3.66 ± 1.95.
↵^† Mean ± SD of SUV2 = 4.43 ± 2.43.
↵^‡ Mean = 20.5%.
↵^§ Lesion 1.
↵^| Lesion 2.
RLL = right lower lobe; Bx = biopsy; LUL = left upper lobe; Res = surgical resection; RUL = right upper lobe; LLL = left lower lobe; SCC = squamous cell carcinoma; XRT = x-ray therapy; RML = right middle lobe.

TABLE 2

Patients with Benign Lesions

Lesion no.	Patient’s age (y)	Patient’s sex	Lesion size (cm)/location	Follow-up: period of stability on CXR/CT or result of resection	SUV1*	SUV2^†	% Change^‡
21	69	M	1.8 × 1.2/RUL	24 mo	1.12	0.73	−39.0
22	44	F	1.3/RML	Resection: inflammatory cells	0.43	0.41	−4.7
23	51	F	1.5/LUL	30 mo	1.58	1.43	−9.5
24	52	M	0.8/RUL	24 mo	0.83	0.46	−44.6
25	56	M	0.9/LUL	28 mo	0.99	0.95	−4.0
26	57	F	1.7 × 1.2/RUL	20 mo	0.68	0.73	7.4
27	51	F	1.0/LLL	23 mo	0.43	0.47	9.3
28	64	M	0.9/LUL	25 mo	0.63	0.71	12.7
29	69	F	0.8/LUL	Resection: granuloma	1.54	1.50	−2.6
30	36	F	0.5/RUL	28 mo	1.33	1.41	6.0
31	48	F	1.1/RLL	24 mo	1.47	1.41	−4.1
32	62	M	1.2/RLL	22 mo	0.53	0.49	−7.5
33	73	F	2.0/LUL	23 mo	1.05	1.00	−4.8
34	51	F	0.9/RUL	22 mo	0.79	0.63	−20.3
35	72	F	0.9/RUL	23 mo	0.75	0.97	29.3
36	47	M	1.0/RUL	Resolved 5 mo after PET scan	1.32	1.11	−15.9
37	54	M	1.0/RML^§	22 mo	2.48	2.64	6.5
38			0.5/RLL^\|	22 mo	2.65	2.85	7.5

↵* Mean ± SD of SUV1 = 1.14 ± 0.64.
↵^† Mean ± SD of SUV2 = 1.11 ± 0.70.
↵^‡ Mean = −4.3%.
↵^§ Lesion 1.
↵^| Lesion 2.
CXR/CT = chest x-ray or CT; RUL = right upper lobe; RML = right middle lobe; LUL = left upper lobe; LLL = left lower lobe; RLL = right lower lobe.