[18F]Fluoroestradiol Radiation Dosimetry in Human PET Studies

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FIGURE 1.
Example of TACs for FES in gallbladder (⧫), liver (▪), and blood (▴). Data are normalized to 37 MBq injected per 56 kg body weight.
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FIGURE 2.
FES activity in bladder (A), gastrointestinal tract (B), and uterus (C). Different symbols are used for different studies. Data are normalized to 37 MBq injected per 56 kg body weight. Fits are shown as solid lines. Gastrointestinal tract and bladder data were fit with rising exponential (Eq. 2), and uterus data were fit with function described in Equation 3. y-axis for bladder is twice as large as for uterus and intestinal tract.

TABLE 1

Tissue Uptake of FES for 37-MBq Injection

Organ	No. of studies	C̃ Mean (SD) (kBq-h/g)	Organ mass (g)	Ã Mean (SD) (MBq-h)
Breast	47	0.7 (0.3)	361	0.2 (0.1)
Gall Bladder	15	31.7 (16.8)	49	1.6 (0.8)
Intestines*
1	4	5.8 (7.0)
2	14 (28)	9.8
3	4 plus pooled	6.6 (6.4)	176 (ULI) + 322 (SmI)	3.3 (3.2)
Blood	48	2.0 (0.5)	347 (heart contents)	0.7 (0.2)
Heart Wall	48	1.8 (0.6)	241	0.4 (0.1)
Kidneys	3	4.2 (0.7)	248	1.0 (0.2)
Liver	49	18.9 (4.8)	1400	26.4 (6.7)
Lungs	48	1.3 (0.5)	651	0.8 (0.3)
Red Marrow	47	1.2 (0.6)	1050	1.2 (0.6)
Spleen	18	1.1 (0.7)	123	0.1 (0.1)
Bladder*
1	2	14.4 (10.1)
2	16 (28)	18.3
3	2 plus pooled	15.7 (7.5)	160	2.5 (1.2)
Uterus*
1	3	4.8 (2.7)
2	10 (18)	7.6
3	3 plus pooled	5.5 (2.6)	79	0.4 (0.2)
Remainder			50,793^†	58.9 (7.6)

↵* These organs also had additional points from more sparsely sampled TACs. 1 = fully sampled curves; 2 = pooled additional data (parentheses indicate number of points used in curve); 3 = mean of fully sampled curves plus additional value from pooled data. These numbers are used for Table 2.
↵† Remainder of body for 56-kg woman.
ULI = large intestine; SmI = small intestine.

TABLE 2

Radiation Absorbed Dose to Organs

Organ	Mean* (mGy/MBq)	SD (mGy/MBq)	25%^† (mGy/MBq)	75%^† (mGy/MBq)
Adrenals	0.023 (85)	0.003	0.021	0.025
Brain	0.010 (36)	0.001	0.009	0.010
Breasts	0.009 (32)	0.002	0.008	0.010
GB wall	0.102 (379)	0.041	0.075	0.134
LLI	0.012 (45)	0.001	0.011	0.013
Small intestine	0.027 (99)	0.015	0.017	0.038
Stomach	0.014 (50)	0.001	0.013	0.014
ULI	0.030 (110)	0.016	0.019	0.042
Heart wall	0.026 (96)	0.004	0.024	0.029
Kidney	0.035 (128)	0.004	0.032	0.038
Liver	0.126 (466)	0.030	0.105	0.149
Lungs	0.017 (61)	0.002	0.015	0.018
Muscle	0.021 (79)	0.001	0.021	0.022
Ovaries	0.018 (66)	0.002	0.016	0.019
Pancreas	0.023 (84)	0.002	0.021	0.024
Red marrow	0.013 (48)	0.002	0.012	0.014
Bone surface	0.014 (53)	0.001	0.014	0.015
Skin	0.005 (18)	0.000	0.005	0.005
Spleen	0.015 (54)	0.003	0.012	0.017
Testes	0.012 (44)	0.001	0.011	0.012
Thymus	0.014 (50)	0.001	0.013	0.014
Thyroid	0.012 (45)	0.001	0.012	0.013
UB wall	0.050 (186)	0.020	0.036	0.066
Uterus	0.039 (145)	0.013	0.031	0.049
Lens	0.009 (33)	0.000	0.009	0.009

↵* Values in parentheses are mrad/mCi.
↵† Determined assuming normal curve with given mean and SD.
GB = gallbladder; LLI = lower large intestine; ULI = upper large intestine; UB = urinary bladder.
Effective dose equivalent = 0.022 mSv/MBq (0.004 SD).