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OtherBASIC SCIENCE INVESTIGATIONS

Radionuclides Linked to a CD74 Antibody as Therapeutic Agents for B-Cell Lymphoma: Comparison of Auger Electron Emitters with β-Particle Emitters

Serengulam V. Govindan, David M. Goldenberg, Sammy E. Elsamra, Gary L. Griffiths, Gaik Lin Ong, Martin W. Brechbiel, Jack Burton, George Sgouros and M. Jules Mattes
Journal of Nuclear Medicine December 2000, 41 (12) 2089-2097;
Serengulam V. Govindan
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David M. Goldenberg
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Sammy E. Elsamra
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Gary L. Griffiths
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Gaik Lin Ong
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Martin W. Brechbiel
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Jack Burton
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George Sgouros
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M. Jules Mattes
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Article Information

vol. 41 no. 12 2089-2097
PubMed 
11138697

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Published online December 1, 2000.

Copyright & Usage 
© 2000

Author Information

  1. Serengulam V. Govindan,
  2. David M. Goldenberg,
  3. Sammy E. Elsamra,
  4. Gary L. Griffiths,
  5. Gaik Lin Ong,
  6. Martin W. Brechbiel,
  7. Jack Burton,
  8. George Sgouros and
  9. M. Jules Mattes
  1. Immunomedics, Inc., Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey; National Institutes of Health, Bethesda, Maryland; and Memorial Sloan-Kettering Cancer Center, New York, New York
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Journal of Nuclear Medicine
Vol. 41, Issue 12
December 1, 2000
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Radionuclides Linked to a CD74 Antibody as Therapeutic Agents for B-Cell Lymphoma: Comparison of Auger Electron Emitters with β-Particle Emitters
Serengulam V. Govindan, David M. Goldenberg, Sammy E. Elsamra, Gary L. Griffiths, Gaik Lin Ong, Martin W. Brechbiel, Jack Burton, George Sgouros, M. Jules Mattes
Journal of Nuclear Medicine Dec 2000, 41 (12) 2089-2097;

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Radionuclides Linked to a CD74 Antibody as Therapeutic Agents for B-Cell Lymphoma: Comparison of Auger Electron Emitters with β-Particle Emitters
Serengulam V. Govindan, David M. Goldenberg, Sammy E. Elsamra, Gary L. Griffiths, Gaik Lin Ong, Martin W. Brechbiel, Jack Burton, George Sgouros, M. Jules Mattes
Journal of Nuclear Medicine Dec 2000, 41 (12) 2089-2097;
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  • PARP-1-Targeted Auger Emitters Display High-LET Cytotoxic Properties In Vitro but Show Limited Therapeutic Utility in Solid Tumor Models of Human Neuroblastoma
  • Monte Carlo Evaluation of Auger Electron-Emitting Theranostic Radionuclides
  • Auger Radiopharmaceutical Therapy Targeting Prostate-Specific Membrane Antigen
  • A Universally Applicable 68Ga-Labeling Technique for Proteins
  • Antitumor Effects and Normal-Tissue Toxicity of 111In-Nuclear Localization Sequence-Trastuzumab in Athymic Mice Bearing HER-Positive Human Breast Cancer Xenografts
  • CD74: A New Candidate Target for the Immunotherapy of B-Cell Neoplasms
  • Nuclear Localizing Sequences Promote Nuclear Translocation and Enhance the Radiotoxicity of the Anti-CD33 Monoclonal Antibody HuM195 Labeled with 111In in Human Myeloid Leukemia Cells
  • Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin
  • Trifunctional Somatostatin-Based Derivatives Designed for Targeted Radiotherapy Using Auger Electron Emitters
  • Anti-CD74 Antibody-Doxorubicin Conjugate, IMMU-110, in a Human Multiple Myeloma Xenograft and in Monkeys
  • In vitro cytotoxicity of carcinoma cells with 111In-labeled antibodies to HER-2
  • Therapy of Small Subcutaneous B-Lymphoma Xenografts with Antibodies Conjugated to Radionuclides Emitting Low-Energy Electrons
  • Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies
  • In vitro Toxicity of A-431 Carcinoma Cells with Antibodies to Epidermal Growth Factor Receptor and Epithelial Glycoprotein-1 Conjugated to Radionuclides Emitting Low-Energy Electrons
  • Cure of SCID Mice Bearing Human B-Lymphoma Xenografts by an Anti-CD74 Antibody-Anthracycline Drug Conjugate
  • Antitumor Effects and Normal Tissue Toxicity of 111In-Labeled Epidermal Growth Factor Administered to Athymic Mice Bearing Epidermal Growth Factor Receptor-Positive Human Breast Cancer Xenografts
  • Targeting Primary Human Ph+ B-Cell Precursor Leukemia-Engrafted SCID Mice Using Radiolabeled Anti-CD19 Monoclonal Antibodies
  • A Comparison of 4 Radionuclides Conjugated to Antibodies for Single-Cell Kill
  • Improved Iodine Radiolabels for Monoclonal Antibody Therapy
  • Intracellular Accumulation of the Anti-CD20 Antibody 1F5 in B-Lymphoma Cells
  • Cooperative Effect of Radioimmunotherapy and Antiangiogenic Therapy with Thalidomide in Human Cancer Xenografts
  • Therapy of Disseminated B-Cell Lymphoma Xenografts in Severe Combined Immunodeficient Mice with an Anti-CD74 Antibody Conjugated with 111Indium, 67Gallium, or 90Yttrium
  • Single-cell Cytotoxicity with Radiolabeled Antibodies
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  • Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology
  • Synthesis and Biologic Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer
  • Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers
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