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Research ArticleBasic Science Investigation
Open Access

Establishing In Vitro Dosimetric Models and Dose–Effect Relationships for 177Lu-DOTATATE in Neuroendocrine Tumors

Giulia Tamborino, Pleun Engbers, Tijmen H. de Wolf, Thom G.A. Reuvers, Rob Verhagen, Mark Konijnenberg and Julie Nonnekens
Journal of Nuclear Medicine May 2025, jnumed.125.269470; DOI: https://doi.org/10.2967/jnumed.125.269470
Giulia Tamborino
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
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Pleun Engbers
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
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Tijmen H. de Wolf
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
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Thom G.A. Reuvers
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
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Rob Verhagen
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
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Mark Konijnenberg
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
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Julie Nonnekens
1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
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Article Information

jnumed.125.269470
DOI 
https://doi.org/10.2967/jnumed.125.269470
PubMed 
40404397

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication January 7, 2025
  • Accepted for publication April 8, 2025
  • Published online May 22, 2025.

Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: https://jnm.snmjournals.org/page/permissions.

Author Information

  1. Giulia Tamborino1,2,
  2. Pleun Engbers1,2,
  3. Tijmen H. de Wolf1,2,
  4. Thom G.A. Reuvers1,2,
  5. Rob Verhagen1,2,
  6. Mark Konijnenberg1 and
  7. Julie Nonnekens1,2
  1. 1Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; and
  2. 2Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
  1. For correspondence or reprints, contact Julie Nonnekens (j.nonnekens{at}erasmusmc.nl).
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Establishing In Vitro Dosimetric Models and Dose–Effect Relationships for 177Lu-DOTATATE in Neuroendocrine Tumors
Giulia Tamborino, Pleun Engbers, Tijmen H. de Wolf, Thom G.A. Reuvers, Rob Verhagen, Mark Konijnenberg, Julie Nonnekens
Journal of Nuclear Medicine May 2025, jnumed.125.269470; DOI: 10.2967/jnumed.125.269470

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Establishing In Vitro Dosimetric Models and Dose–Effect Relationships for 177Lu-DOTATATE in Neuroendocrine Tumors
Giulia Tamborino, Pleun Engbers, Tijmen H. de Wolf, Thom G.A. Reuvers, Rob Verhagen, Mark Konijnenberg, Julie Nonnekens
Journal of Nuclear Medicine May 2025, jnumed.125.269470; DOI: 10.2967/jnumed.125.269470
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Keywords

  • cellular dosimetry
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  • neuroendocrine tumors
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