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Research ArticleBasic Science Investigation
Open Access

Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning

Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima and Kuangyu Shi
Journal of Nuclear Medicine March 2025, jnumed.124.268175; DOI: https://doi.org/10.2967/jnumed.124.268175
Carlos Vinícius Gomes
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
2Institute of Radiology and Nuclear Medicine, Lucerne University Teaching and Research Hospital, Lucerne, Switzerland;
3Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland;
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Yizhou Chen
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Isabel Rauscher
4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;
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Song Xue
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
5Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Vienna, Austria;
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Andrei Gafita
4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;
6Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California;
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Jiaxi Hu
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Robert Seifert
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Lorenzo Mercolli
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Julia Brosch-Lenz
4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;
7Institute of Nuclear Medicine, Glen Burnie, Maryland;
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Jimin Hong
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Marc Ryhiner
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Sibylle Ziegler
8Department of Nuclear Medicine, Hannover Medical School (MHH), Hannover, Germany;
9Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany; and
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Ali Afshar-Oromieh
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Axel Rominger
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Matthias Eiber
4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;
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Thiago Viana Miranda Lima
2Institute of Radiology and Nuclear Medicine, Lucerne University Teaching and Research Hospital, Lucerne, Switzerland;
10Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
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Kuangyu Shi
1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Article Information

jnumed.124.268175
DOI 
https://doi.org/10.2967/jnumed.124.268175
PubMed 
40113223

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 3, 2024
  • Accepted for publication February 20, 2025
  • Published online March 20, 2025.

Article Versions

  • You are currently viewing a previous version of this article (March 20, 2025 - 07:50).
  • latest version (March 27, 2025 - 08:48).
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Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: https://jnm.snmjournals.org/page/permissions.

Author Information

  1. Carlos Vinícius Gomes1,2,3,
  2. Yizhou Chen1,
  3. Isabel Rauscher4,
  4. Song Xue1,5,
  5. Andrei Gafita4,6,
  6. Jiaxi Hu1,
  7. Robert Seifert1,
  8. Lorenzo Mercolli1,
  9. Julia Brosch-Lenz4,7,
  10. Jimin Hong1,
  11. Marc Ryhiner1,
  12. Sibylle Ziegler8,9,
  13. Ali Afshar-Oromieh1,
  14. Axel Rominger1,
  15. Matthias Eiber4,
  16. Thiago Viana Miranda Lima2,10 and
  17. Kuangyu Shi1
  1. 1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
  2. 2Institute of Radiology and Nuclear Medicine, Lucerne University Teaching and Research Hospital, Lucerne, Switzerland;
  3. 3Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland;
  4. 4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;
  5. 5Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Vienna, Austria;
  6. 6Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California;
  7. 7Institute of Nuclear Medicine, Glen Burnie, Maryland;
  8. 8Department of Nuclear Medicine, Hannover Medical School (MHH), Hannover, Germany;
  9. 9Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany; and
  10. 10Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
  1. For correspondence or reprints, contact Kuangyu Shi (kuangyu.shi{at}unibe.ch).
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Journal of Nuclear Medicine: 66 (5)
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Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning
Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima, Kuangyu Shi
Journal of Nuclear Medicine Mar 2025, jnumed.124.268175; DOI: 10.2967/jnumed.124.268175

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Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning
Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima, Kuangyu Shi
Journal of Nuclear Medicine Mar 2025, jnumed.124.268175; DOI: 10.2967/jnumed.124.268175
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