Article Figures & Data
Figures
- FIGURE 1.
Concept of iSTP dosimetry in radiopharmaceutical therapy, encompassing MTP and STP methods. p.i. = postinjection.
- FIGURE 2.
Relation between MTP and predicted Teff for left kidney, right kidney, liver, and spleen across all therapy cycles.
- FIGURE 3.
RADs in TIA by organ for both STP (iSTP and Hänscheid) methods compared with MTP method. Illustrated for left and right kidney, liver, and spleen at earlier postinjection time points (2 h*, 20 h, 43 h, and 69 h). *2 h tsc is not applicable to Hänscheid method; included for comparison purposes. ***P < 0.001. ns = not significant.
- FIGURE 4.
Statistical correlation between predicted Teff when using pretherapy data before each cycle and before first cycle. Nonpaired Mann–Whitney test was performed for each therapy cycle, represented by columns, for left kidney, right kidney, liver, and spleen. ns = not significant.
- FIGURE 5.
RADs in absorbed dose calculated and grouped by cycle using iSTP model from data preceding first therapy cycle.
Tables
- TABLE 1.
General Characteristics of Patients per Therapy Cycle, Represented as Mean Values of Age, Weight, PSA Level, LDH, Creatinine, and Hemoglobin
Characteristics per cycle Parameter Cycle 1 Cycle 2 Cycle 3 Cycle ≥4 Number of patients 20 12 6 4 Age (y) 69 ± 9 69 ± 9 69 ± 9 69 ± 9 Weight (kg) 82.3 ± 10.6 82.3 ± 10.6 82.3 ± 10.6 82.3 ± 10.6 PSA (ng/mL)* 714.59 591.35 611.67 438.19 LDH† 328.05 275.25 270.83 247.67 Creatinine‡ 1.0 0.9 0.9 0.9 Hemoglobin§ 11.52 10.78 10.45 10.72 - TABLE 2.
Absorbed Dose and Teff Results for Left Kidney, Right Kidney, Liver, and Spleen, Presented as Mean ± SD, with Minimum and Maximum Values
Organ Absorbed dose (Gy) Teff (h) Left kidney 3.7 ± 1.9 (0.8–8.3) 35 ± 16 (7–65) Right kidney 3.7 ± 1.9 (0.9–8.6) 34 ± 16 (7–65) Liver 0.07 ± 0.04 (0.02–0.23) 11 ± 4 (6–25) Spleen 0.7 ± 0.4 (0.2–1.6) 9 ± 4 (5–25)
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