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Research ArticleBasic Science Investigation

Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure

Robel K. Gebre, Alexis Moscoso Rial, Sheelakumari Raghavan, Heather J. Wiste, Fiona Heeman, Alejandro Costoya-Sánchez, Christopher G. Schwarz, Anthony J. Spychalla, Val J. Lowe, Jonathan Graff-Radford, David S. Knopman, Ronald C. Petersen, Michael Schöll, Melissa E. Murray, Clifford R. Jack, Prashanthi Vemuri and for the Alzheimer’s Disease Neuroimaging Initiative
Journal of Nuclear Medicine July 2024, jnumed.123.267273; DOI: https://doi.org/10.2967/jnumed.123.267273
Robel K. Gebre
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Alexis Moscoso Rial
2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
3Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden;
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Sheelakumari Raghavan
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Heather J. Wiste
4Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota;
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Fiona Heeman
2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
3Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden;
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Alejandro Costoya-Sánchez
5Universidade de Santiago de Compostela, Santiago de Compostela, Spain;
6Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain;
7Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, Spain;
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Christopher G. Schwarz
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Anthony J. Spychalla
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Val J. Lowe
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Jonathan Graff-Radford
8Department of Neurology, Mayo Clinic, Rochester, Minnesota;
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David S. Knopman
8Department of Neurology, Mayo Clinic, Rochester, Minnesota;
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Ronald C. Petersen
4Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota;
8Department of Neurology, Mayo Clinic, Rochester, Minnesota;
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Michael Schöll
2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
3Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden;
9Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom; and
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Melissa E. Murray
10Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
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Clifford R. Jack Jr.
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Prashanthi Vemuri
1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
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Article Information

jnumed.123.267273
DOI 
https://doi.org/10.2967/jnumed.123.267273
PubMed 
39054278

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 25, 2023
  • Accepted for publication June 25, 2024
  • Published online July 25, 2024.

Article Versions

  • You are currently viewing a previous version of this article (July 25, 2024 - 06:57).
  • View the most recent version of this article
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Robel K. Gebre1,
  2. Alexis Moscoso Rial2,3,
  3. Sheelakumari Raghavan1,
  4. Heather J. Wiste4,
  5. Fiona Heeman2,3,
  6. Alejandro Costoya-Sánchez5,6,7,
  7. Christopher G. Schwarz1,
  8. Anthony J. Spychalla1,
  9. Val J. Lowe1,
  10. Jonathan Graff-Radford8,
  11. David S. Knopman8,
  12. Ronald C. Petersen4,8,
  13. Michael Schöll2,3,9,
  14. Melissa E. Murray10,
  15. Clifford R. Jack Jr.1,
  16. Prashanthi Vemuri1,
  17. for the Alzheimer’s Disease Neuroimaging Initiative
  1. 1Department of Radiology, Mayo Clinic, Rochester, Minnesota;
  2. 2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
  3. 3Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden;
  4. 4Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota;
  5. 5Universidade de Santiago de Compostela, Santiago de Compostela, Spain;
  6. 6Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain;
  7. 7Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, Spain;
  8. 8Department of Neurology, Mayo Clinic, Rochester, Minnesota;
  9. 9Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom; and
  10. 10Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
  1. For correspondence or reprints, contact Prashanthi Vemuri (vemuri.prasanthi{at}mayo.edu).
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Journal of Nuclear Medicine: 66 (5)
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Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure
Robel K. Gebre, Alexis Moscoso Rial, Sheelakumari Raghavan, Heather J. Wiste, Fiona Heeman, Alejandro Costoya-Sánchez, Christopher G. Schwarz, Anthony J. Spychalla, Val J. Lowe, Jonathan Graff-Radford, David S. Knopman, Ronald C. Petersen, Michael Schöll, Melissa E. Murray, Clifford R. Jack, Prashanthi Vemuri, for the Alzheimer’s Disease Neuroimaging Initiative
Journal of Nuclear Medicine Jul 2024, jnumed.123.267273; DOI: 10.2967/jnumed.123.267273

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Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure
Robel K. Gebre, Alexis Moscoso Rial, Sheelakumari Raghavan, Heather J. Wiste, Fiona Heeman, Alejandro Costoya-Sánchez, Christopher G. Schwarz, Anthony J. Spychalla, Val J. Lowe, Jonathan Graff-Radford, David S. Knopman, Ronald C. Petersen, Michael Schöll, Melissa E. Murray, Clifford R. Jack, Prashanthi Vemuri, for the Alzheimer’s Disease Neuroimaging Initiative
Journal of Nuclear Medicine Jul 2024, jnumed.123.267273; DOI: 10.2967/jnumed.123.267273
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Keywords

  • Neurology
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  • machine learning
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  • tau
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