PET/CT-Based Radiogenomics Supports KEAP1/NFE2L2 Pathway Targeting for Non–Small Cell Lung Cancer Treated with Curative Radiotherapy

Vincent Bourbonne; Moncef Morjani; Olivier Pradier; Mathieu Hatt; Vincent Jaouen; Solène Querellou; Dimitris Visvikis; François Lucia; Ulrike Schick

doi:10.2967/jnumed.123.266749

Research ArticleClinical Investigation

PET/CT-Based Radiogenomics Supports KEAP1/NFE2L2 Pathway Targeting for Non–Small Cell Lung Cancer Treated with Curative Radiotherapy

Vincent Bourbonne, Moncef Morjani, Olivier Pradier, Mathieu Hatt, Vincent Jaouen, Solène Querellou, Dimitris Visvikis, François Lucia and Ulrike Schick

Journal of Nuclear Medicine February 2024, jnumed.123.266749; DOI: https://doi.org/10.2967/jnumed.123.266749

Vincent Bourbonne

1Department of Radiation Oncology, University Hospital, Brest, France;

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

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Moncef Morjani

1Department of Radiation Oncology, University Hospital, Brest, France;

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Olivier Pradier

1Department of Radiation Oncology, University Hospital, Brest, France;

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

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Mathieu Hatt

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

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Vincent Jaouen

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

3Institut Mines-Télécom Atlantique, Brest, France;

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Solène Querellou

4Nuclear Medicine Department, University Hospital, Brest, France; and

5Groupe d’Étude de la Thrombose Occidentale GETBO (INSERM UMR 1304), Université de Bretagne Occidentale, Brest, France

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Dimitris Visvikis

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

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François Lucia

1Department of Radiation Oncology, University Hospital, Brest, France;

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

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Ulrike Schick

1Department of Radiation Oncology, University Hospital, Brest, France;

2LaTIM UMR 1101 INSERM, University Brest, Brest, France;

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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PET/CT-Based Radiogenomics Supports KEAP1/NFE2L2 Pathway Targeting for Non–Small Cell Lung Cancer Treated with Curative Radiotherapy

Vincent Bourbonne, Moncef Morjani, Olivier Pradier, Mathieu Hatt, Vincent Jaouen, Solène Querellou, Dimitris Visvikis, François Lucia, Ulrike Schick

Journal of Nuclear Medicine Feb 2024, jnumed.123.266749; DOI: 10.2967/jnumed.123.266749

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PET/CT-Based Radiogenomics Supports KEAP1/NFE2L2 Pathway Targeting for Non–Small Cell Lung Cancer Treated with Curative Radiotherapy

Vincent Bourbonne, Moncef Morjani, Olivier Pradier, Mathieu Hatt, Vincent Jaouen, Solène Querellou, Dimitris Visvikis, François Lucia, Ulrike Schick

Journal of Nuclear Medicine Feb 2024, jnumed.123.266749; DOI: 10.2967/jnumed.123.266749

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Keywords

radiation sensitivity
KEAP1/NFE2L2
PET
lung cancer
radiomics

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